scholarly journals Effects of Aging, Long-Term and Lifelong Exercise on the Urinary Metabolic Footprint of Rats

Metabolites ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 481
Author(s):  
Anastasia Tzimou ◽  
Stefanos Nikolaidis ◽  
Olga Begou ◽  
Aikaterina Siopi ◽  
Olga Deda ◽  
...  
Keyword(s):  
Amino Acids ◽  
Multivariate Analysis ◽  
Univariate Analysis ◽  
Cost Effective ◽  
Male Wistar Rats ◽  
Urinary Amino Acids ◽  
Urinary Amino ◽  
Effects Of Aging ◽  
Lifelong Exercise

Life expectancy has risen in the past decades, resulting in an increase in the number of aged individuals. Exercise remains one of the most cost-effective treatments against disease and the physical consequences of aging. The purpose of this research was to investigate the effects of aging, long-term and lifelong exercise on the rat urinary metabolome. Thirty-six male Wistar rats were divided into four equal groups: exercise from 3 to 12 months of age (A), lifelong exercise from 3 to 21 months of age (B), no exercise (C), and exercise from 12 to 21 months of age (D). Exercise consisted in swimming for 20 min/day, 5 days/week. Urine samples collection was performed at 3, 12 and 21 months of life and their analysis was conducted by liquid chromatography-mass spectrometry. Multivariate analysis of the metabolite data did not show any discrimination between groups at any of the three aforementioned ages. However, multivariate analysis discriminated the three ages clearly when the groups were treated as one. Univariate analysis showed that training increased the levels of urinary amino acids and possibly protected against sarcopenia, as evidenced by the higher levels of creatine in the exercising groups. Aging was accompanied by decreased levels of urinary amino acids and signs of increased glycolysis. Concluding, both aging and, to a lesser degree, exercise affected the rat urinary metabolome, including metabolites related to energy metabolism, with exercise showing a potential to mitigate the consequences of aging.

scholarly journals 74 Hyperexcretion of Urinary Amino Acids and Phosphorus in the Vitamin D-Deficient Holtzman Rat

1967 ◽  
Vol 1 (3) ◽  
pp. 219-219
Author(s):  
John Grose ◽  
Charles Scriver ◽  
John Fawcett
Keyword(s):  
Amino Acids ◽  
Vitamin D ◽  
Urinary Amino Acids ◽  
Urinary Amino

Paper chromatography of urinary amino acids

1956 ◽  
Vol 1 (1) ◽  
pp. 75-79 ◽  
Author(s):  
Jorge Awapara ◽  
Yukiko Sato
Keyword(s):  
Amino Acids ◽  
Paper Chromatography ◽  
Urinary Amino Acids ◽  
Urinary Amino

scholarly journals DETERMINAN PEMILIHAN METODE KONTRASEPSI JANGKA PANJANG PADA AKSEPTOR KB AKTIF DI PUSKESMAS PEDAMARAN

2019 ◽  
Vol 1 (01) ◽  
Author(s):  
Lusia Weni ◽  
Muhammad Yuwono ◽  
Haerawati Idris
Keyword(s):  
Multivariate Analysis ◽  
Family Planning ◽  
Information Needs ◽  
Large Population ◽  
Univariate Analysis ◽  
Bivariate Analysis ◽  
Contraceptive Methods ◽  
Long Acting ◽  
Selection Of

<span lang="IN">Determinant of the selection of long-term contraceptive methods on family planning acceptors in Pedamaran community health center. </span><span lang="EN"> The population problem faced by Indonesia is a large population with a low quality of life. Uncontrolled population rate will cause baby booming so information needs to be disseminated about the benefits of family planning (FP). Long-term contraceptive method has a high level of effectiveness and can reduce the rate of population growth. </span><span lang="EN">This study aim to determine the factors that affect the selection of long-term contraceptive methods in active family planning acceptors.</span><span lang="EN">This study used a cross-sectional study design and using</span><span lang="IN"> simple random sampling</span><span lang="EN"> technique, consisted of 243 acceptors. Analyzes of data were univariate analysis, bivariate analysis using chi-square test with α = 0.05 and 95% confidence interval value, and multivariate analysis using binary logistic regression.</span><span lang="EN">Based on multivariate analysis was the variables significantly related to the selection of long-acting contraception include </span><span lang="IN">age (p = 0.01; OR = 2,24; 95% CI: 1,17-4,29), education (p = 0.01; OR = 0,31; 95% CI: 0,13-0,75) and number of children (p = 0.03; OR = 2; 95% CI: 1,05-3,81).</span><span lang="EN"> Thus, age was the variable that had the greatest impact on determining the selection of long-acting contraception.</span><span lang="IN">The </span><span lang="EN">acceptors with ≥ 35 years old, low educated and have &gt;2 children more likely to choose long-acting contraception. It is hoped that family planning workers can educate and persuade people of all ages with </span><span lang="IN">different educational backgrounds so total fertility rate can be reduce.</span>

Ampicillinuria and Ampicillin Crystalluria

PEDIATRICS ◽  
1971 ◽  
Vol 48 (4) ◽  
pp. 636-639
Author(s):  
Joseph L. Potter ◽  
Arthur G. Weinberg ◽  
Raymond West
Keyword(s):  
Amino Acids ◽  
False Positive ◽  
Isobutyric Acid ◽  
Urinary Amino Acids ◽  
Amino Isobutyric Acid ◽  
Urinary Amino

Four patients with ampicillinuria and ampicillin crystalluria have been reported. The presence of ampicillin leads to false positive spots for leucine/isoleucine, phenylalanine, and β-amino isobutyric acid in paper chromatograms of the urinary amino acids, and to a false-positive spot for phenylalanine in paper electrophoretograms. Crystalluria, due to ampicillin, is also described. Its significance remains to be determined.

Prognostic analysis of Chinese patients with metastasic renal cell cancer (mRCC) receiving sorafenib: A multicenter retrospective study.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e15582-e15582 ◽  
Author(s):  
Fang Guo ◽  
Xiaodong Xie ◽  
Zhaozhe Liu ◽  
Xishuang Song ◽  
Qifu Zhang ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Lung Metastasis ◽  
Univariate Analysis ◽  
Chinese Patients ◽  
Related Factors ◽  
Metastatic Lesions ◽  
Long Term Study ◽  
Previous Therapy ◽  
Ecog Ps

e15582 Background: This study was to investigate long-term efficacy of sorafenib and survival-related factors in Chinese patients with mRCC. Methods: 406 consecutive patients enrolled in this study between Oct. 2006 and Oct. 2009 from 6 comprehensive cancer centres in China. All cases were diagnosed as mRCC histopathologically without exception. 400mg sorafenib was orally taken twice daily until PD, death or intolerable toxic reaction. The primary endpoint was OS. The secondary endpoints were PFS and survival-related factors such as gender, age, ECOG PS, previous therapy and primary metastatic lesions. Data was analyzed using the SPSS statistical software. OS and PFS curves were output using the Kaplan-Meier method. Clinical parameters were included on univariate and multivariate analysis to evaluate associations with OS and PFS by the log-rank test and Cox proportional hazard models, P<0.05 (two-sided) was considered statistically significant. Results: 131 patients were available for survival analysis, including 96 males and 35 females. The median age was 60 years old. The median follow-up periods were 16.9 months. The median OS was 16.1 months. 1-year, 2-year and 3-year survival rates were 64.9%, 35.9% and 5.3%, respectively. The median PFS was 10.5 months. Univariate analysis demonstrated that OS was significantly associated with ECOG PS, metastatic lesions and previous therapy, whereas PFS was merely associated with ECOG PS and previous therapy. Multivariate analysis suggested that ECOG PS and previous therapy were independent prognostic factors for OS(P=0.004, P=0.019) and PFS (P=0.000, P=0.003), metastatic lesions was merely independent prognostic factor for OS (P=0.003). In the subgroup of patients with visceral metastasis, patients with lung metastasis alone had better prognosis than those with liver metastasis or dimerous metastasis. Conclusions: This long-term study demonstrated that sorafenib had good effects on Chinese patients with mRCC, especially for patients with lung metastasis alone. ECOG PS, metastatic lesions and previous therapy could be important parameters for survival and need attention in future.

Changes in plasma and urinary amino acids following estrogen administration to males

Metabolism ◽  
1965 ◽  
Vol 14 (11) ◽  
pp. 1214-1219 ◽  
Author(s):  
Horace H. Zinneman ◽  
Byron U. Musa ◽  
Richard P. Doe
Keyword(s):  
Amino Acids ◽  
Urinary Amino Acids ◽  
Urinary Amino ◽  
Estrogen Administration
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