DETERMINAN PEMILIHAN METODE KONTRASEPSI JANGKA PANJANG PADA AKSEPTOR KB AKTIF DI PUSKESMAS PEDAMARAN

Determinant of the selection of long-term contraceptive methods on family planning acceptors in Pedamaran community health center. The population problem faced by Indonesia is a large population with a low quality of life. Uncontrolled population rate will cause baby booming so information needs to be disseminated about the benefits of family planning (FP). Long-term contraceptive method has a high level of effectiveness and can reduce the rate of population growth. This study aim to determine the factors that affect the selection of long-term contraceptive methods in active family planning acceptors.This study used a cross-sectional study design and using simple random sampling technique, consisted of 243 acceptors. Analyzes of data were univariate analysis, bivariate analysis using chi-square test with α = 0.05 and 95% confidence interval value, and multivariate analysis using binary logistic regression.Based on multivariate analysis was the variables significantly related to the selection of long-acting contraception include age (p = 0.01; OR = 2,24; 95% CI: 1,17-4,29), education (p = 0.01; OR = 0,31; 95% CI: 0,13-0,75) and number of children (p = 0.03; OR = 2; 95% CI: 1,05-3,81). Thus, age was the variable that had the greatest impact on determining the selection of long-acting contraception.The acceptors with ≥ 35 years old, low educated and have >2 children more likely to choose long-acting contraception. It is hoped that family planning workers can educate and persuade people of all ages with different educational backgrounds so total fertility rate can be reduce.

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PARITAS, PEKERJAAN DAN PENDIDIKAN BERHUBUNGAN DENGAN PEMILIHAN ALAT KONTRASEPSI MKJP PADA AKSEPTOR KB

Jurnal Kebidanan Malahayati ◽

10.33024/jkm.v7i4.5243 ◽

2021 ◽

Vol 7 (4) ◽

pp. 744-750

Author(s):

Novi Eniastina Jasa ◽

Akma Listiana ◽

Risneni Risneni

Keyword(s):

Family Planning ◽

Contraceptive Method ◽

Maternal Education ◽

Univariate Analysis ◽

P Value ◽

Contraceptive Device ◽

Contraceptive Methods ◽

Cross Sectional ◽

Selection Of

Introduction : Long Term Contraceptive Method (MKJP) is a contraceptive method used to delay, space out pregnancy, and stop fertility that is used in the long term, which includes IUD (Intra Uterine Device), Implant (KB) and tubectomy. The MKJP failure rate is reported to be 0.2 per thousand users, while the non MKJP method is reported to be more than 10 per thousand users. From this, it can be seen that the MKJP method is more effective in preventing pregnancy in its users. The purpose of this study was to determine the relationship between parity, employment and education with the selection of Long-term Contraceptive Methods (MKJP) at PMB Rosbiatul.Method : The research design is correlational descriptive with a cross sectional approach. The population in this study were all MKJP and Non MKJP family planning acceptors who visited PMB Rosbiatul with a total of 194 respondents. The sampling technique in this study is total sampling where the entire population is used as a research sample, namely as many as 194 respondents. The variables in this study were parity, occupation and education with the selection of the MKJP Contraceptive Device. The measuring instrument used is a data collection format in the form of a checklist. This research was carried out from January to August in 2021. The data analysis used was quantitative analysis carried out through univariate analysis to see the distribution of each variable, bivariate analysis using Chi Square.Results : Of the 194 family planning acceptors, 82 people (42.3%) used the Long-Term Contraception Method (MKJP) and 112 people (57.7%) used the Non-MKJP Contraception Method. From 194 there were 123 multiparous (63.4%), and 71 primiparous (36.6%). From 194 people, 69 respondents (35.6%) worked and 125 people (64.4%) did not work. From 194 people, there are 133 respondents (68.6%) with higher education and 61 respondents (31.4%) with low education. From the results of the study, it is known that there is a relationship between the selection of the MKJP KB with maternal education with a p value of 0.002, there is a relationship between the selection of the MKJP KB with the mother's occupation, with a p value of 0.003, and there is a relationship between the selection of the MKJP KB with maternal parity with a p value. value 0.003.Conclusion : The conclusion of the study is that there is a significant relationship between parity, education and mother's occupation with the choice of long-term contraceptive method (MKJP). Suggestion : Health workers are expected to be able to provide counseling and information about Long-Term Contraceptive Methods (MKJP) for effectiveness in preventing or spacing pregnancies. Keywords : parity, employment, education, MKJP ABSTRAK Latar Belakang: Metode Kontrasepsi Jangka Panjang (MKJP) adalah metode kontrasepsi yang digunakan untuk menunda, menjarangkan kehamilan, serta menghentikan kesuburan yang digunakan dalam jangka panjang, yang meliputi IUD (Intra Uterine Device) , Implant (susuk KB) dan tubektomi. Angka kegagalan MKJP dilaporkan sebesar 0,2 perseribu pengguna, sedangkan metode non MKJP dilaporkan terjadi lebih dari 10 perseribu pengguna. Dari hal tersebut terlihat bahwa metode MKJP lebih efektif untuk dapat mencegah terjadinya kehamilan pada penggunanya.. Tujuan dari penelitian ini adalah untuk mengetahui Hubungan paritas, pekerjaan dan pendidikan dengan pemilihan Metode Kontrasepsi jangka Panjang (MKJP) di PMB Rosbiatul.Metode Penelitian: Design penelitian adalah deskriptif korelasional dengan pendekatan cross sectional. Populasi pada penelitian ini adalah semua akseptor KB MKJP dan Non MKJP yang mengunjungi PMB Rosbiatul dengan jumlah 194 responden. Tekhnik pengambilan sample pada penelitian ini adalah total sampling dimana seluruh populasi di jadikan sample penelitian yaitu sebanyak 194 responden. Variabel dalam penelitian ini adalah paritas, pekerjaan dan pendidikan dengan pemilihan Alat Kontrasepsi MKJP. Alat ukur yang digunakan adalah format pengumpulan data berupa checklist. Penelitian ini dilaksanakan pada bulan Januari sampai bulan Agustus pada tahun 2021. Analisis data yang digunakan adalah analisis kuantitatif dilakukan melalui analisis univariat untuk melihat distribusi masing-masing variabel, analisis bivariate menggunakan Chi Square.Hasil penelitian: Dari 194 akseptor KB sebanyak 82 orang ( 42,3%) menggunakan Metode Kontrasepsi Jangka Panjang (MKJP) dan sebanyak 112 orang (57,7%) menggunakan Metode Kontrasepsi Non MKJP. Dari 194 ada 123 multipara (63,4%), dan 71 0rang primipara (36,6%). Dari 194 orang sebesar 69 responden (35,6%) bekerja dan 125 orang (64,4%) tidak bekerja. Dari 194 orang terdapat 133 responden (68,6%) pendidikan tinggi dan 61 responden (31,4%) pendidikan rendah. Dari hasil penelitian diketahui terdapat hubungan antara pemilihan KB MKJP dengan pendidikan ibu dengan nilai p.value 0,002, terdapat hubungan antara pemilihan KB MKJP dengan pekerjaan ibu, dengan nilai p value 0,003, dan terdapat hubungan antara pemilihan KB MKJP dengan paritas ibu dengan nilai p.value 0,003.Kesimpulan: Ada hubungan yang signifikan antara paritas, pendidikan dan pekerjaan ibu dengan pemilihan metode kontrasepsi jangka panjang (MKJP).Saran: Bagi tenaga kesehatan diharapkan dapat memberikan konseling serta informasi tentang Metode Kontrasepsi Jangka Panjang (MKJP) untuk efektifitas dalam mencegah atau menjarangkan kehamilan Kata Kunci: paritas, pekerjaan, pendidikan, MKJP

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PEMAHAMAN DAN DUKUNGAN SUAMI TERHADAP KEIKUTSERTAAN IBU MENJADI AKSEPTOR KB IUD DI KECAMATAN SECANGGANG LANGKAT

Jurnal Delima Harapan ◽

10.31935/delima.v8i2.140 ◽

2021 ◽

Vol 8 (2) ◽

pp. 70-74

Author(s):

Surya Anita ◽

Dewi Rismauli Bancin ◽

Friska Sitorus

Keyword(s):

Family Planning ◽

Significant Relationship ◽

Family Planning Program ◽

Bivariate Analysis ◽

P Value ◽

Contraceptive Methods ◽

Cross Sectional ◽

The Family ◽

Effective Contraceptive

The decrease in TFR (Total Fertility Rate) will be closer to the condition of the population growing in balance, a strategy is needed in the implementation of the family planning program. Activities that can be carried out are promoting long-term effective contraceptive methods. This study aims to determine the understanding and support of husbands for the participation of mothers in becoming IUD KB acceptors in Secanggang District, Langkat Regency. The research design used in this study was an analytical survey with cross sectional approach. The sample in this study was 30 respondents who came and wanted to do family planning. The data analysis used was univariate and bivariate analysis. The results of this study indicate that there is a significant relationship between Husband's understanding of the participation of mothers in becoming IUD family planning acceptors in Secanggang District, Langkat Regency, with a pvalue of 0.000. And there is a significant relationship between the husband's support for the participation of mothers in becoming IUD family planning acceptors in Secanggang District, Langkat Regency with a p value of 0,000. It is hoped that it can increase respondents' knowledge about contraceptives so that they can support and understand their wives in choosing contraceptives. Keywords: Understanding, Support, IUD

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FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PENGGUNAAN KONTRASEPSI AKDR (ALAT KONTRASEPSI DALAM RAHIM) DI KLINIK BUDI MULIA MEDIKA PALEMBANG TAHUN 2015

Jurnal Kebidanan : Jurnal Medical Science Ilmu Kesehatan Akademi Kebidanan Budi Mulia Palembang ◽

10.35325/kebidanan.v6i2.90 ◽

2019 ◽

Vol 6 (2) ◽

Author(s):

INTAN SARI INTAN SARI

Keyword(s):

Family Planning ◽

Contraceptive Use ◽

Intrauterine Device ◽

Univariate Analysis ◽

Survey Method ◽

Bivariate Analysis ◽

P Value ◽

Chi Square ◽

Influential Variable

ABSTRAK AKDR (Alat Kontrasepsi Dalam Rahim) merupakan kontrasepsi yang dimasukkan melalui serviks dan dipasang di dalam uterus. Banyak keunggulan metode kontrasepsi AKDR) / AKDR ini, namun tidak semua yang berminat dikarenakan berbagai alasan yang berbeda-beda seperti takut efek samping, takut proses pemasangan, dilarang oleh suami karena takut benangnya mengganggu saat bersenggama dan kurangnya pengetahuan tentang KB AKDR. Penelitian ini bertujuan untuk diketahuinya faktor-faktor yang berhubungan antara umur, pendidikan, pekerjaan dan paritas dengan Penggunaan Kontrasepsi AKDR di Klinik Budi Mulia Medika Palembang tahun 2015. Jenis penelitian ini adalah kuantitatif menggunakan metode survei analitik dengan pendekatan crosss sectional. Populasi dalam penelitian ini adalah seluruh peserta KB aktif yang menggunakan kontrasepsi sebanyak 256 orang. Analisa data menggunakan uji statistik Chi–Square. Hasil analisis univariat ini menunjukkan bahwa responden yang menggunakan kontrasepsi AKDR sebesar 146 (57%) lebih besar dari yang menggunakan kontrasepsi selain AKDR 110 (43%). Analisa bivariat menunjukkan ada hubungan yang bermakna antara Umur (P value=0,010), Pendidikan (P value=0,005), Pekerjaan (P value=0,025) dan Paritas (P value=0,000) dengan Pemakaian Kontrasepsi AKDR. Dari hasil analisis multivariat menunjukkan variabel yang paling berpengaruh adalah paritas dengan Exp (B) = 2.928. Disarankan Hasil penelitian ini dapat dijadikan sebagai bahan informasi bagi klinik untuk mengevaluasi program KB terutama kontrasepsi AKDR pada wanita dan dapat mengetahui jumlah akseptor yang menggunakan kontrasepsi jangka panjang atau KB efektif serta dapat mengadakan penyuluhan tentang kontrasepsi AKDR sehingga membuat semua akseptor KB aktif berganti cara untuk berminat menggunakan kontrasepsi jangka panjang yaitu kontrasepsi AKDR. ABSTRACT The IUD (intrauterine device) is a contraceptive that is inserted through the cervix and placed in the uterus. Many advantages of the IUD contraceptive method) / IUD, but not all that interested in due to various reasons which vary as the fear of side effects, fear of the installation process, forbidden by the husband for fear of disturbing yarn during intercourse and lack of knowledge about the IUD birth control. This study aims to know the factors related between age, education, work and parity with the IUD contraceptive use in the Budi Mulia Medika Palembang clinic 2015. The research is a quantitative survey method crosss sectional analytic approach. The population in this study are all planning participants actively use contraception as many as 256 people. Analysis of data using statistical test Chi-Square. The results of univariate analysis showed that respondents who use IUD contraception is 146 (57%) greater than that using an IUD contraception other than 110 (43%). Bivariate analysis showed no significant relationship between age (P value = 0.010), Education (P value = 0.005), Employment (P value = 0.025) and parity (P value = 0.000) with the IUD Contraception. Multivariate analysis showed that the most influential variable is parity with Exp (B) = 2,928. Suggested results of this study can be used as information for the clinic to evaluate family planning programs, especially contraceptive IUD in women and can determine the number of acceptors that use long-term contraception or family planning effectively and be able to conduct counseling on contraceptive IUD thus making all acceptors actively changed the way for interested using long-term contraception is contraception IUD.

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The Effect of Women's Autonomy in the Uptake of Long-Acting and Permanent Contraception Methods among Women Reproductive Age in East Kalimantan

Jurnal Kesehatan Komunitas ◽

10.25311/keskom.vol6.iss1.511 ◽

2020 ◽

Vol 6 (1) ◽

pp. 98-103

Author(s):

Annisa Nurrachmawati Syaiful bahri ◽

Ike Anggreini G ◽

Mugia Bayu Raharja ◽

Dewi Endah Ramadhani

Keyword(s):

Family Planning ◽

Reproductive Age ◽

Bivariate Analysis ◽

Contraceptive Methods ◽

Childbearing Age ◽

Women’S Autonomy ◽

Women's Autonomy ◽

East Kalimantan ◽

Permanent Contraception ◽

Long Acting

Background: Despite decreased fertility rate, East Kalimantan Province still facing unmet needs. Moreover, almost all contraceptive use in East Kalimantan depends on short-acting contraceptive methods. Only a few studies have ever been conducted on women's autonomy in relation to Long-Acting Permanent Contraception Methods (LAPMs) choices. It is, therefore, essential to find the associated factors affecting LAPMs uptake. This study aimed to analyze the influence of sociodemographic, knowledge, women's autonomy and fertility on LAPMs uptake at the household level. Methods: The data derived from the Indonesian Demographic and Health Survey (IDHS) 2017 of East Kalimantan Province. As much as 570 women of childbearing age (10–49 years) with marital status who still using contraception in any method was included as samples. Results: Factors correlate with the uptake of LAPMs in the bivariate analysis were age, insurance ownership, family planning knowledge and women's autonomy (p value<0.05). While in the multivariate analysis only women autonomy and insurance ownership were related to the uptake of LAPMs. Conclusion: This finding provides evidence for including women empowerment programs in the family planning program. Keywords: Family planning, women autonomy, long acting contraceptive methods

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Hubungan Jenis Pekerjaan dengan Pemilihan KB Metode Kontrasepsi Jangka Panjang

Jurnal Ilmiah Kesehatan ◽

10.48144/jiks.v14i1.540 ◽

2021 ◽

Vol 14 (1) ◽

pp. 105

Author(s):

Tri Yunita Fitria Damayanti ◽

Dwi Kurnia Purnama Sari ◽

Umu Qonitun

Keyword(s):

Family Planning ◽

Contraceptive Method ◽

Contraceptive Methods ◽

Cross Sectional ◽

Planning Methods ◽

The Government ◽

Long Acting ◽

The Relationship ◽

Family Planning Methods

Abstrak. Capaian Akseptor Metode Kontrasepsi Jangka Panjang (MKJP) sangat rendah dibandingkan dengan KB Non-MKJP. Penelitian ini membahas analisa hubungan jenis pekerjaan ibu dengan pemilihan KB metode kontrasepsi jangka panjang yang dipilih. Pendekatan cross sectional digunakan dalam penelitian ini. Populasi dan sampel dalam penelitian ini adalah Seluruh Akseptor yang menggunakan KB jangka panjang Di Dusun Kenthu, Desa Tahulu Kecamatan Merakurak, Kabupaten Tuban Bulan Juli-Agustus 2020. Variabel independen dalam penelitian ini adalah jenis pekerjaan ibu, sedangkan jenis kontrasepsi jangka panjang merupakan variabel dependen. Analisa data dengan menggunakan korelasi Spearman. Berdasarkan analisa hasil penelitian menunjukkan bahwa jenis pekerjaan tidak berhubungan dengan pemilihan KB Metode kontrasepsi jangka panjang. Jenis pekerjaan dapat dipastikan tidak berhubungan dengan pemilihan metode KB, maka untuk meningkatkan capaian program KB MKJP, pemerintah dapat melakukan penyuluhan tentang efek samping, indikasi, kontraindikasi, cara kerja semua alat kontrasepsi, dan komplikasi MKJP. Kata kunci : MKJP, Keluarga berencana, Jenis Pekerjaan The Corellation between Type of Work and Selection of Long Acting Contraception Method In Kenthu Hamlet, Tahul Village, Merakurak District, Tuban Regency in 2020 Abstract. The accomplishment of acceptors of long-term contraceptive methods is very low compared to long-term non-contraceptive methods. This study discusses the analysis of the relationship between the type of mother's occupation and the choice of long-term contraceptive method. A cross-sectional approach was used in this study. The population and sample in this study were all acceptors using long-term family planning in Kenthu Hamlet, Tulu Village, Merakurak District, Tuban Regency in July-August 2020. The independent variable in this study was the type of maternal occupation, while the type of long-term contraception was the dependent variable. Data analysis using the Spearman correlation. Based on the analysis of the research results, it shows that the type of work is not related to the choice of family planning methods of long-term contraception. The type of work can be ascertained that it is not related to the choice of family planning methods, so to improve the achievements of the long-term contraceptive method, the government can provide counseling about side effects, indications, contraindications, how all contraceptives work, and complications of the long-term contraceptive method. Keywords: long-term contraceptive, family planning, type of work

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Environmental Scanning Mechanism and Its Effects on the Performance: Evidence from UAE

International Journal of Business and Management ◽

10.5539/ijbm.v13n1p190 ◽

2017 ◽

Vol 13 (1) ◽

pp. 190

Author(s):

Mansour S. M. A. M. Lotayif

Keyword(s):

Multivariate Analysis ◽

Multiple Regression ◽

Descriptive Analysis ◽

Univariate Analysis ◽

Bivariate Analysis ◽

Environmental Scanning ◽

Significant Relationships ◽

Scanning Frequency ◽

Scanning Mechanism

The current Research aims at figuring out relationships between performance (as measured by ROE and PM) and demographics, interest in scanning, kinds of scanning, scanning frequency, sources of scanning (impersonal and personal), and obstacles of scanning. Experiences of 292 UAE executives have been used to fulfill these objectives. Via SPSS package release ten and seventeen, multivariate analysis (e.g. Multiple Regression), bivariate analysis (e.g. WSRT), and univariate analysis (e.g. descriptive analysis like mean, percentage, and sum) were conducted to explore the network of relationships amongst variables. Significant relationships between performance (as measured ROE) and interest in scanning, scanning frequency, sources of scanning (impersonal), and obstacles of scanning are existed. Significant relationships between performance (as measured by PM) and interest in scanning, scanning frequency, sources of scanning (personal), and sources of scanning (impersonal) are also existed. Finally, the current study revealed that UAE businesses are conducting regular, proactive, and hoc scanning more often than irregular, reactive, and primitive scanning.

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IMPLANTS AND INJECTIONS ARE FAVORITE CONTRACEPTION TOOLS IN SUMATERA SELATAN

Jurnal Kesehatan Komunitas ◽

10.25311/keskom.vol5.iss3.383 ◽

2019 ◽

Vol 5 (3) ◽

pp. 147-150

Author(s):

Mukni Mukni

Keyword(s):

Regression Analysis ◽

Family Planning ◽

Linear Regression ◽

Linear Regression Analysis ◽

Simple Linear Regression ◽

Contraceptive Methods ◽

Poverty Level ◽

Short Term ◽

Simple Linear Regression Analysis

Background: The choice of contraception by family planning acceptors greatly determines the success rate of the family planning program, because not all contraceptives are suitable for someone. This study aims to determine what types of contraceptives chosen by family planning acceptors and whether there is a relationship between the selection of contraceptives there is a relationship with the poverty level in the District / City in South Sumatra in 2015, 2016 and 2017. The source of data obtained from the Provincial BPS South Sumatra. Methodology: This study uses a descriptive approach with a simple linear regression analysis method. Results: The results of the analysis were grouped into two, first long-term contraception method KB IUD, MOW, MOP and implants, both short-term contraceptive methods namely injection KB, pill and condom from 17 regencies / cities in South Sumatra. Conclusion: contraception devices that are mostly chosen by long-term contraceptive methods are implants (10000-35000) or 10-20 times larger than other contraceptives. Short-term contraceptive methods are injections, (7700 - 76000) or 5-7 times greater than other contraceptives. From the simple linear regression analysis it turns out that the relationship of long-term contraceptive selection by acceptors with the poverty level is R² = 0.7382 and the short-term method R² = 0.9223. District / City Governments in South Sumatra should provide alokon (contraceptive devices and drugs) in accordance with the type and amount in the field to be on target

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Factors that affect the discontinuation of family planning methods in Myanmar: analysis of the 2015–16 Myanmar Demographic and Health Survey

Contraception and Reproductive Medicine ◽

10.1186/s40834-020-00126-5 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Khaing Nwe Tin ◽

Thae Maung Maung ◽

Thiri Win

Keyword(s):

Logistic Regression ◽

Family Planning ◽

Health Survey ◽

Unmet Need ◽

Contraceptive Methods ◽

Multivariable Logistic Regression ◽

Unplanned Pregnancies ◽

Contraceptive Discontinuation ◽

Voluntary Choice

Abstract Background Access to family planning contributes up to a 44% reduction in maternal deaths. Since the majority of unplanned pregnancies and abortions occur in women who were either not using contraception or not using it consistently, greater access to contraception and more consistent use of contraception are crucial in the reduction of unplanned pregnancies and abortions. This study aims to determine which types of contraceptives are most often discontinued, the reasons for discontinuation, and the factors that influence contraceptive discontinuation for women in Myanmar. Methods This study is a secondary data analysis of calendar data from the 2015–16 Myanmar Demographic Health Survey. The dependent variable is discontinuation of contraception within 12 months among episodes of contraceptive use in the 5 years before the survey among women age 15–49. Multivariable logistic regression was used to identify the predictors of contraceptive discontinuation. Results The 12-month discontinuation rate for all contraceptive methods was 39%. The discontinuation rates for short-term methods were remarkably high (43% for pills and 42% for injectables), while the rate for long-term methods was very low (7% for intrauterine devices and 0.2% for implants). Discontinuation while still in need of contraception was high (55%) although 28% of those women switched to other modern methods. Multivariable logistic regression showed the factors associated with contraceptive discontinuation were a woman’s age, location (state/region), wealth, and number of births within the past 5 years. Conclusions The high rate of discontinuation while in need is very alarming given goals to reduce the unmet need for family planning in Myanmar. Family planning programs must ensure timely, informed method-switching by women who discontinue contraception, especially among women for whom discontinuation is the highest (age 45–49, middle and richest wealth quintile, regions where high discontinuation and multiparity); increase the availability of long-term contraceptive methods, and improve counseling that ensures clients’ informed and voluntary choice of family planning services.

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Prognostic analysis of Chinese patients with metastasic renal cell cancer (mRCC) receiving sorafenib: A multicenter retrospective study.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.e15582 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. e15582-e15582 ◽

Cited By ~ 1

Author(s):

Fang Guo ◽

Xiaodong Xie ◽

Zhaozhe Liu ◽

Xishuang Song ◽

Qifu Zhang ◽

...

Keyword(s):

Multivariate Analysis ◽

Lung Metastasis ◽

Univariate Analysis ◽

Chinese Patients ◽

Related Factors ◽

Metastatic Lesions ◽

Long Term Study ◽

Previous Therapy ◽

Ecog Ps

e15582 Background: This study was to investigate long-term efficacy of sorafenib and survival-related factors in Chinese patients with mRCC. Methods: 406 consecutive patients enrolled in this study between Oct. 2006 and Oct. 2009 from 6 comprehensive cancer centres in China. All cases were diagnosed as mRCC histopathologically without exception. 400mg sorafenib was orally taken twice daily until PD, death or intolerable toxic reaction. The primary endpoint was OS. The secondary endpoints were PFS and survival-related factors such as gender, age, ECOG PS, previous therapy and primary metastatic lesions. Data was analyzed using the SPSS statistical software. OS and PFS curves were output using the Kaplan-Meier method. Clinical parameters were included on univariate and multivariate analysis to evaluate associations with OS and PFS by the log-rank test and Cox proportional hazard models, P<0.05 (two-sided) was considered statistically significant. Results: 131 patients were available for survival analysis, including 96 males and 35 females. The median age was 60 years old. The median follow-up periods were 16.9 months. The median OS was 16.1 months. 1-year, 2-year and 3-year survival rates were 64.9%, 35.9% and 5.3%, respectively. The median PFS was 10.5 months. Univariate analysis demonstrated that OS was significantly associated with ECOG PS, metastatic lesions and previous therapy, whereas PFS was merely associated with ECOG PS and previous therapy. Multivariate analysis suggested that ECOG PS and previous therapy were independent prognostic factors for OS(P=0.004, P=0.019) and PFS (P=0.000, P=0.003), metastatic lesions was merely independent prognostic factor for OS (P=0.003). In the subgroup of patients with visceral metastasis, patients with lung metastasis alone had better prognosis than those with liver metastasis or dimerous metastasis. Conclusions: This long-term study demonstrated that sorafenib had good effects on Chinese patients with mRCC, especially for patients with lung metastasis alone. ECOG PS, metastatic lesions and previous therapy could be important parameters for survival and need attention in future.

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