A 3D Printed Self-Sustainable Cell-Encapsulation Drug Delivery Device for Periocular Transplant-Based Treatment of Retinal Degenerative Diseases

Self-sustainable release of brain-derived neurotrophic factor (BDNF) to the retina using minimally invasive cell-encapsulation devices is a promising approach to treat retinal degenerative diseases (RDD). Herein, we describe such a self-sustainable drug delivery device with human retinal pigment epithelial (ARPE-19) cells (cultured on collagen coated polystyrene (PS) sheets) enclosed inside a 3D printed semi-porous capsule. The capsule was 3D printed with two photo curable polymers: triethylene glycol dimethacrylate (TEGDM) and polyethylene glycol dimethylacrylate (PEGDM). The capsule’s semi-porous membrane (PEGDM) could serve three functions: protecting the cells from body’s immune system by limiting diffusion (5.97 ± 0.11%) of large molecules like immunoglobin G (IgG)(150 kDa); helping the cells to survive inside the capsule by allowing diffusion (43.20 ± 2.16%) of small molecules (40 kDa) like oxygen and necessary nutrients; and helping in the treatment of RDD by allowing diffusion of cell-secreted BDNF to the outside environment. In vitro results showed a continuous BDNF secretion from the device for at least 16 days, demonstrating future potential of the cell-encapsulation device for the treatment of RDD in a minimally invasive and self-sustainable way through a periocular transplant.

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DC Bead: In Vitro Characterization of a Drug-delivery Device for Transarterial Chemoembolization

Journal of Vascular and Interventional Radiology ◽

10.1097/01.rvi.0000195323.46152.b3 ◽

2006 ◽

Vol 17 (2) ◽

pp. 335-342 ◽

Cited By ~ 271

Author(s):

Andrew L. Lewis ◽

M. Victoria Gonzalez ◽

Andrew W. Lloyd ◽

Brenda Hall ◽

Yiqing Tang ◽

...

Keyword(s):

Drug Delivery ◽

Transarterial Chemoembolization ◽

Delivery Device ◽

Drug Delivery Device ◽

In Vitro Characterization

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Advances of Microneedles in Biomedical Applications

Molecules ◽

10.3390/molecules26195912 ◽

2021 ◽

Vol 26 (19) ◽

pp. 5912

Author(s):

Jie Xu ◽

Danfeng Xu ◽

Xuan Xuan ◽

Huacheng He

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Minimally Invasive ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Wound Repair ◽

Delivery Systems ◽

Delivery Device ◽

Drug Delivery Device ◽

Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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Evaluation of a chloroaluminium phthalocyanine-loaded magnetic nanoemulsion as a drug delivery device to treat glioblastoma using hyperthermia and photodynamic therapy

RSC Advances ◽

10.1039/c6ra26105a ◽

2017 ◽

Vol 7 (15) ◽

pp. 9115-9122 ◽

Cited By ~ 18

Author(s):

L. B. de Paula ◽

F. L. Primo ◽

M. R. Pinto ◽

P. C. Morais ◽

A. C. Tedesco

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Cell Lines ◽

Maghemite Nanoparticles ◽

Delivery Device ◽

Drug Delivery Device

The study describes the development of magnetic nanoemulsion loaded with citrate-coated maghemite nanoparticles and photosensitizer and the in vitro studies using cell lines while combining the use of hyperthermia and photodynamic therapy therapies.

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