Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording

During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices. Among them, the combination of optogenetics and electrophysiology provides an opportunity for facilitating optogenetic approaches. In this study, a novel design of an optrode array was proposed for realizing optical modulation and electrophysiological recording. A 4 × 4 optrode array and five-channel recording electrodes were assembled as a disposable part, while a reusable part comprised an LED (light-emitting diode) source and a power line. After the characterization of the intensity of the light delivered at the fiber tips, in vivo animal experiment was performed with transgenic mice expressing channelrhodopsin, showing the effectiveness of optical activation and neural recording.

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Light-emitting diode-based transcranial photoacoustic measurement of sagittal sinus oxyhemoglobin saturation in hypoxic neonatal piglets

10.1101/2020.08.22.262451 ◽

2020 ◽

Author(s):

Jeeun Kang ◽

Raymond C. Koehler ◽

Shawn Adams ◽

Ernest M. Graham ◽

Emad M. Boctor

Keyword(s):

Mean Squared Error ◽

Light Emitting Diode ◽

Cost Effective ◽

Preclinical Study ◽

Light Emitting ◽

Neonatal Piglets ◽

Sagittal Sinus ◽

Photoacoustic Measurement

AbstractWe present a light-emitting diode (LED)-based transcranial photoacoustic measurement (LED-trPA) of oxyhemoglobin (HbO2) saturation at superior sagittal sinus (SSS) in hypoxic neonatal piglets. The optimal LED imaging wavelengths and frame averaging scheme were determined based on in vivo characterization of transcranial sensitivity. Based on the framework (690/850 nm with >20 frame averaging), graded hypoxia was successfully identified in neonatal piglets in vivo with less than 10.0 % of root mean squared error (RMSE). This preclinical study suggests the feasibility of a rapid, cost-effective, and safe LED-trPA monitoring of perinatal hypoxia-ischemia and prompt interventions for clinical use.

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Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.1909850116 ◽

2019 ◽

Vol 116 (43) ◽

pp. 21427-21437 ◽

Cited By ~ 20

Author(s):

Yi Zhang ◽

Daniel C. Castro ◽

Yuan Han ◽

Yixin Wu ◽

Hexia Guo ◽

...

Keyword(s):

Large Scale ◽

Light Emitting Diode ◽

Single Experiment ◽

Light Emitting ◽

3 Dimensional ◽

Neuronal Populations ◽

Neuroscience Research ◽

Wide Range ◽

Temporal Profiles

Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation.

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Characterization and Elimination of Forward Snapback Defects in GaAs Light Emitting Diodes

ISTFA 1996: Conference Proceedings from the 22nd International Symposium for Testing and Failure Analysis ◽

10.31399/asm.cp.istfa1996p0239 ◽

1996 ◽

Author(s):

J. Zimmer ◽

D. Nielsen ◽

T.A. Anderson ◽

M. Schade ◽

N. Saha ◽

...

Keyword(s):

Photoelectron Spectroscopy ◽

Light Emitting Diode ◽

Elevated Concentration ◽

Forward Voltage ◽

Light Emitting ◽

Intermittent Yield ◽

Si Doped ◽

Secondary Ion ◽

Furnace Pressure

Abstract The p-n junction of a GaAs light emitting diode is fabricated using liquid phase epitaxy (LPE). The junction is grown on a Si doped (~1018/cm3) GaAs substrate. Intermittent yield loss due to forward voltage snapback was observed. Historically, out of specification forward voltage (Vf) parameters have been correlated to abnormalities in the junction formation. Scanning electron (SEM) and optical microscopy of cleaved and stained samples revealed a continuous layer of material approximately 2.5 to 3.0 urn thick at the n-epi/substrate interface. Characterization of a defective wafer via secondary ion mass spectroscopy (SIMS) revealed an elevated concentration of O throughout the region containing the defect. X-ray Photoelectron Spectroscopy (XPS) and Auger Electron Spectroscopy (AES) data taken from a wafer prior to growth of the epi layers did not reveal any unusual oxidation or contamination. Extensive review of the processing data suggested LPE furnace pressure was the obvious source of variability. Processing wafers through the LPE furnace with a slight positive H2 gas pressure has greatly reduced the occurrence of this defect.

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Characterization of a mortar made with cement and sludge from the light-emitting diode manufacturing process

Construction and Building Materials ◽

10.1016/j.conbuildmat.2014.01.078 ◽

2014 ◽

Vol 56 ◽

pp. 106-112 ◽

Cited By ~ 1

Author(s):

Wei-Jer Wang ◽

Cheng-Der Wang ◽

Tzen-Chin Lee ◽

Cheng-Cheng Chang

Keyword(s):

Manufacturing Process ◽

Light Emitting Diode ◽

Light Emitting

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In vitro and in vivo Efficacy of New Blue Light Emitting Diode Phototherapy Compared to Conventional Halogen Quartz Phototherapy for Neonatal Jaundice

Journal of Korean Medical Science ◽

10.3346/jkms.2005.20.1.61 ◽

2005 ◽

Vol 20 (1) ◽

pp. 61 ◽

Cited By ~ 23

Author(s):

Yun Sil Chang ◽

Jong Hee Hwang ◽

Hyuk Nam Kwon ◽

Chang Won Choi ◽

Sun Young Ko ◽

...

Keyword(s):

Blue Light ◽

Neonatal Jaundice ◽

Light Emitting Diode ◽

In Vivo Efficacy ◽

Light Emitting

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In-situ characterization of polymer crystallization using a low-cost light emitting diode array as optical receiver with photogain

Proceedings of the 21st IEEE Instrumentation and Measurement Technology Conference (IEEE Cat. No.04CH37510) ◽

10.1109/imtc.2004.1351544 ◽

2004 ◽

Author(s):

F. De Santis ◽

H.C. Neitzert

Keyword(s):

Light Emitting Diode ◽

Low Cost ◽

Polymer Crystallization ◽

Optical Receiver ◽

Diode Array ◽

In Situ Characterization ◽

Light Emitting

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Retinal damage related to high-intensity light-emitting diode exposure: An in vivo study

American Journal of Orthodontics and Dentofacial Orthopedics ◽

10.1016/j.ajodo.2021.01.026 ◽

2021 ◽

Author(s):

Marcela Emílio de Araújo ◽

Marina Bozzini Paies ◽

Ana Beatriz Arrais ◽

Fernando Ladd Lobo ◽

Ruthnaldo Rodrigues Melo de Lima ◽

...

Keyword(s):

High Intensity ◽

Light Emitting Diode ◽

In Vivo Study ◽

Retinal Damage ◽

Light Emitting ◽

High Intensity Light

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Design, Measurements and Characterization of Smart Electronic Board for PV Streetlight based on LED and High Intensity Discharge Lamps

Advanced Instrument Engineering ◽

10.4018/978-1-4666-4165-5.ch012 ◽

2013 ◽

pp. 153-165

Author(s):

Paolo Visconti ◽

Daniele Romanello ◽

Giovanni Zizzari ◽

Vito Ventura ◽

Giorgio Cavalera

Keyword(s):

Rural Areas ◽

High Intensity ◽

Light Emitting Diode ◽

Light Emitting ◽

Electronic Board ◽

Lighting Systems ◽

And Control ◽

Near Future ◽

Hid Lamps

This work presents an electronic board for driving and control of High Intensity Discharge (HID) lamps and Light Emitting Diode (LED) lamps. The proposed electronic board is able to drive HID or LED lamps by means of a reconfigurable output. This feature allows using the ballast in lighting systems that currently use traditional discharge lamps, as well as keeping the same ballast when discharge lamps are replaced by LED modules in the near future, when LED street lighting systems will be more affordable. Additionally, since the lighting system is designed to be used in rural areas where there is no public electricity, each lighting point incorporates a system to convert solar energy into continuous voltage by means of photovoltaic panels. In this work, energy saving issues are taken into account.

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