scholarly journals Pathological and Virological Studies of p16-Positive Oropharyngeal Carcinoma with a Good Response to Neoadjuvant Chemotherapy

2020 ◽  
Vol 8 (10) ◽  
pp. 1497
Author(s):  
Daisuke Inukai ◽  
Taichi Kan ◽  
Shunpei Yamanaka ◽  
Hiroki Okamoto ◽  
Yasushi Fujimoto ◽  
...  

Human papillomavirus (HPV)-related, p16-positive oropharyngeal carcinoma is considered to be sensitive to anticancer drugs, and the standard treatment is therefore chemoradiotherapy, rather than surgery, especially for aggressive disease. However, with this higher sensitivity, chemotherapy alone may achieve a pathological complete response (CR), making radiation therapy unnecessary. A 46-year-old man with p16-positive squamous cell carcinoma (SCC) of the lateral oropharynx (palatine tonsil) underwent neoadjuvant chemotherapy. This achieved clinically significant tumor shrinkage and therefore surgery was performed for subsequent definitive treatment. Clinical and CT findings indicated a good effect of neoadjuvant chemotherapy on the tumor. A biopsy prior to chemotherapy revealed SCC, which demonstrated p16 immunoreactivity and positive signals for high-risk HPV by RNA in situ hybridization. The post-chemotherapy surgical specimen showed pathological CR and no p16 positive cells nor positive signals for high-risk HPV those were detected in the pre-chemotherapy specimen. There are some reports of chemotherapy alone achieving pathological CR in cases of p16-positive oropharyngeal carcinoma, but none have included high-risk HPV RNA findings. This is the first report of the disappearance of cancer cells as well as p16 staining and a positive signal for high-risk HPV. Achieving pathological CR confirmed by immunohistochemistry and high-risk HPV RNA in situ hybridization in a solid tumor with chemotherapy alone suggests that chemotherapy may have both an antitumor effect and an antiviral effect. Forgoing subsequent radiotherapy and undergoing surgery might be unnecessary and follow-up instead might be sufficient in such cases. Into the future, in an optimal tailored treatment approach, the option of neoadjuvant chemotherapy should be considered for management of p16-positive oropharyngeal carcinoma. Other options such as tumor immunotherapy are also expected to be effective.

2007 ◽  
Vol 31 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Christina S. Kong ◽  
Bonnie L. Balzer ◽  
Megan L. Troxell ◽  
Bruce K. Patterson ◽  
Teri A. Longacre

2021 ◽  
Vol 42 (1) ◽  
pp. 102782
Author(s):  
Krish Suresh ◽  
Parth V. Shah ◽  
Sydney Coates ◽  
Borislav A. Alexiev ◽  
Sandeep Samant

2018 ◽  
Vol 26 (7) ◽  
pp. 617-620 ◽  
Author(s):  
Khaleel I. Al-Obaidy ◽  
Chia-Sui Kao ◽  
Muhammad T. Idrees

Introduction. Extramammary Paget disease (EMPD) of the vulva has been shown to express p16 by immunohistochemistry (IHC), however, p16 expression in the vulva and scrotum has not been extensively studied in relation to human papillomavirus (HPV) within EMPD of both the vulva and scrotum. Design. Twenty-two cases of EMPD (vulva, 16; scrotum, 6) were found in our laboratory information system. P16 and HPV IHC were performed. Any p16 reactivity less than 10% was considered negative. HPV in situ hybridization for both low- and high-risk HPV was also performed on all cases. Results. Of the 6 scrotal EMPD, 3 (50%) showed weak to moderate positive reactivity for p16 by IHC. Of the 16 vulvar EMPD, 13 (81%) were positive for p16, with at least moderate (2+) intensity with a mean expression of 33.3% (range = 10% to 80%) and 62% (range = 20% to 95%) in scrotal and vulvar EMPD, respectively. None of the scrotal or vulvar cases showed positive reactivity for HPV either by IHC or in situ hybridization. Conclusion. Both vulvar and scrotal EMPD can express p16 by IHC, more commonly vulvar than scrotal; however, no HPV was detected either by IHC or in situ hybridization. EMPD of vulva and scrotum does not appear to be related to HPV, and p16 expression may be regulated through a different mechanism.


2019 ◽  
Vol 90 ◽  
pp. 97-105 ◽  
Author(s):  
Reija Randén-Brady ◽  
Timo Carpén ◽  
Lauri Jouhi ◽  
Stina Syrjänen ◽  
Caj Haglund ◽  
...  

1993 ◽  
Vol 25 (3) ◽  
pp. 191-198 ◽  
Author(s):  
C. S. Herrington ◽  
S. M. Anderson ◽  
A. K. Graham ◽  
J. O'D. McGee

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