scholarly journals Anti-HTLV-1/2 IgG Antibodies in the Breastmilk of Seropositive Mothers

2021 ◽  
Vol 9 (7) ◽  
pp. 1413
Author(s):  
Carolina Rosadas ◽  
Timothy Woo ◽  
Jana Haddow ◽  
Aileen Rowan ◽  
Graham P. Taylor
Keyword(s):  
Antibody Titer ◽  
Strong Correlation ◽  
Proviral Load ◽  
Alternative Methods ◽  
Igg Antibodies ◽  
Child Transmission ◽  
Milk Samples ◽  
Lower Quantity ◽  
Igg Binding ◽  
Mother To Child

Background: HTLV-1/2 mother-to-child transmission (MTCT) is an important route for the maintenance of HTLV-1/2 within populations and disproportionally contributes to the burden of HTLV-1-associated diseases. Avoidance of breastfeeding is the safest recommendation to prevent MTCT. Due to the benefits of breastfeeding, alternative methods that would allow seropositive mothers to breastfeed their babies are needed. There is limited knowledge about HTLV-1/2 infection and breastmilk. Methods: Paired blood and milk samples collected from HTLV-1/2 seropositive mothers were tested for HTLV-1 proviral load (PVL) quantification and for the detection of anti-HTLV-1/2 IgG. Results: All breastmilk samples had detectable anti-HTLV-1/2 IgG. HTLV-1/2 proviral DNA was detected in all samples except for one. HTLV-1 PVL and IgG binding ratio (BR) was similar in milk and plasma. However, antibody titer was significantly higher in blood (Median (95%CI): Milk:128 (32–512); Plasma:131,584 (16,000–131,584), p < 0.05). There was a strong correlation between HTLV-1 PVL, anti-HTLV-1/2 IgG BR, and titer when comparing milk and blood. PVL did not correlate with antibody BR nor titer in blood or milk. Conclusions: Anti-HTLV-1/2 IgG are present in milk in the same proportion as blood but in lower quantity. PVL in milk correlates with blood.

scholarly journals Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 123
Author(s):  
Elizabeth Centeno-Tablante ◽  
Melisa Medina-Rivera ◽  
Julia L. Finkelstein ◽  
Heather S. Herman ◽  
Pura Rayco-Solon ◽  
...  
Keyword(s):  
Breast Milk ◽  
Zika Virus ◽  
Mother To Child Transmission ◽  
Inclusion Criteria ◽  
Rt Pcr ◽  
Child Transmission ◽  
Zikv Infection ◽  
Milk Samples ◽  
Clinical Complications ◽  
Mother To Child

We systematically searched regional and international databases and screened 1658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant to examine the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding-related practices. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother–children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications was found to be associated with ZIKV RNA in breast milk. This review updates our previous report by including 12 new articles, in which we found no evidence of ZIKV mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to determine if ZIKV can be transmitted through breastfeeding.

scholarly journals Safety of Breastfeeding in Mothers with SARS-CoV-2 Infection

2020 ◽  
Author(s):  
Qingqing Luo ◽  
Lan Chen ◽  
Dujuan Yao ◽  
Jianwen Zhu ◽  
Xiangzhi Zeng ◽  
...  
Keyword(s):  
Breast Milk ◽  
Antibody Test ◽  
Maternal Blood ◽  
Child Transmission ◽  
Limited Evidence ◽  
Third Trimester ◽  
Milk Samples ◽  
Mother To Child ◽  
Negative Conclusion

Background: The outbreak of Coronavirus Disease 2019 (COVID-19) is threatening a surging number of populations worldwide, including women in breastfeeding period. Limited evidence is available concerning breastfeeding in women with COVID-19. Methods: Twenty-three pregnant women and puerperae were enrolled in the study. To evaluate the effect of breastfeeding on SARS-CoV-2 transmission, the presence of SARS-CoV-2, IgG and IgM in breast milk, maternal blood and infant blood were assessed. Feeding patterns were also recorded in follow-up. Results: No positive detection for SARS-CoV-2 of neonates was found. All breast milk samples were negative for the detection of SARS-CoV-2. The presence of IgM ofSARS-CoV-2 in breast milk was correlated with maternal blood. The results of IgG detection for SARS-CoV-2 were negative in all breast milk samples. All the infants were in healthy condition while six of them were fed with whole or partial breast milk. Eight infants received antibody test for SARS-CoV-2 in one month after birth and the results were all negative. Conclusion: Findings from this small number of cases suggest that there is currently no evidence for mother-to-child transmission via breast feeding in women with COVID-19 in the third trimester and puerperium.

scholarly journals Update on the Transmission of Zika Virus Through Breast Milk and Breastfeeding: A Systematic Review of the Evidence

2020 ◽  
Author(s):  
Elizabeth Centeno-Tablante ◽  
Melisa Medina-Rivera ◽  
Julia L Finkelstein ◽  
Heather Herman ◽  
Pura Rayco-Solon ◽  
...  
Keyword(s):  
Breast Milk ◽  
Zika Virus ◽  
Mother To Child Transmission ◽  
Inclusion Criteria ◽  
Child Transmission ◽  
Zikv Infection ◽  
Milk Samples ◽  
Clinical Complications ◽  
Breastfeeding Practices ◽  
Mother To Child

To gain new insights into the potential of mother-to-child transmission of Zika virus (ZIKV) through breast milk or breastfeeding practices, we systematically searched regional and international databases and screened 1,658 non-duplicate records describing women with suspected or confirmed ZIKV infection, intending to breastfeed or give breast milk to an infant. Fourteen studies met our inclusion criteria and inform this analysis. These studies reported on 97 mother-children pairs who provided breast milk for ZIKV assessment. Seventeen breast milk samples from different women were found positive for ZIKV via RT-PCR, and ZIKV replication was found in cell cultures from five out of seven breast milk samples from different women. Only three out of six infants who had ZIKV infection were breastfed, no evidence of clinical complications were found to be associated with ZIKV RNA in breast milk. This review updates our previous report by synthesizing the evidence from 12 new articles and we find no evidence of mother-to-child transmission through breast milk intake or breastfeeding. As the certainty of the present evidence is low, additional studies are still warranted to completely understand any potential of transmission of ZIKV through breastfeeding.

Mother-to-child transmission of HIV: developing integration of healthcare programmes with clinical, social and basic research studies

2003 ◽  
Vol 92 (11) ◽  
pp. 1343-1348
Author(s):  
Menu E ◽  
Scarlatti G ◽  
Barr&#x000E9;-Sinoussi F ◽  
Gray G ◽  
Bollinger B ◽  
...  
Keyword(s):  
Basic Research ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Mother To Child ◽  
Research Studies

Community Based HIV Screening in Pregnant Women and Provision of Prevention of Mother to Child Transmission Care in Rural Zambia

2017 ◽  
Vol 1 (8) ◽  
Author(s):  
Mary Shilalukey Ngoma ◽  
Tepa Nkumbula ◽  
Wilbroad Mutale ◽  
Chabala Chishala ◽  
Reuben Mbewe ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Hiv Screening ◽  
Mother To Child Transmission ◽  
Child Transmission ◽  
Community Based ◽  
Rural Zambia ◽  
Mother To Child
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