scholarly journals Metagenome-Scale Metabolic Network Suggests Folate Produced by Bifidobacterium longum Might Contribute to High-Fiber-Diet-Induced Weight Loss in a Prader–Willi Syndrome Child

2021 ◽  
Vol 9 (12) ◽  
pp. 2493
Author(s):  
Baoyu Xiang ◽  
Liping Zhao ◽  
Menghui Zhang
Keyword(s):  
Weight Loss ◽  
Metabolic Network ◽  
Dietary Intervention ◽  
Bifidobacterium Longum ◽  
Prader Willi Syndrome ◽  
Fecal Microbiome ◽  
High Fiber ◽  
Fiber Diet ◽  
Microbial Strains ◽  
High Fiber Diet

Gut-microbiota-targeted nutrition intervention has achieved success in the management of obesity, but its underlying mechanism still needs extended exploration. An obese Prader–Willi syndrome boy lost 25.8 kg after receiving a high-fiber dietary intervention for 105 days. The fecal microbiome sequencing data taken from the boy on intervention days 0, 15, 30, 45, 60, 75, and 105, along with clinical indexes, were used to construct a metagenome-scale metabolic network. Firstly, the abundances of the microbial strains were obtained by mapping the sequencing reads onto the assembly of gut organisms through use of reconstruction and analysis (AGORA) genomes. The nutritional components of the diet were obtained through the Virtual Metabolic Human database. Then, a community model was simulated using the Microbiome Modeling Toolbox. Finally, the significant Spearman correlations among the metabolites and the clinical indexes were screened and the strains that were producing these metabolites were identified. The high-fiber diet reduced the overall amount of metabolite secretions, but the secretions of folic acid derivatives by Bifidobacterium longum strains were increased and were significantly relevant to the observed weight loss. Reduced metabolites might also have directly contributed to the weight loss or indirectly contribute by enhancing leptin and decreasing adiponectin. Metagenome-scale metabolic network technology provides a cost-efficient solution for screening the functional microbial strains and metabolic pathways that are responding to nutrition therapy.

scholarly journals PSXI-33 Effects of weight loss and feeding a high-protein, high-fiber diet on blood metabolite profiles, body composition and voluntary physical activity in overweight dogs

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 318-319
Author(s):  
Thunyaporn Phungviwatnikul ◽  
Sara E Belchik ◽  
Kelly S Swanson
Keyword(s):  
Physical Activity ◽  
Weight Loss ◽  
Body Composition ◽  
High Protein ◽  
High Fiber ◽  
Lean Muscle Mass ◽  
Fiber Diet ◽  
Voluntary Physical Activity ◽  
High Fiber Diet ◽  
Over Time

Abstract Canine obesity can be managed by dietary energy restriction using a specifically formulated weight loss diet. The objective of this study was to determine the effects of weight loss on body composition, voluntary physical activity, and blood metabolites of overweight dogs while being fed a high-protein, high-fiber diet. All procedures were approved by the University of Illinois Institutional Animal Care and Use Committee prior to experimentation. Twelve overweight adult spayed female dogs (BW: 15.3±2.1 kg, BCS: 8.1±0.6) were fed a high-protein (CP: 42.0% DMB), high-fiber (TDF: 22.0% DMB) diet during a 5-wk baseline phase (wk 0) to identify food intake needed to maintain BW. A 24-wk weight loss phase followed. After wk 0, food was initially provided at 80% the amount needed to maintain BW and then adjusted weekly with a goal of 1.5–2% weight loss per wk. Data were analyzed statistically overtime using SAS 9.4. After 24 wk, dogs lost 31.2% of initial BW (P < 0.0001), with 1.4±0.7% weight loss per wk. BCS decreased by 2.8 units (P < 0.0001). During weight loss, dogs consumed an average of 457.5±61.4 kcal/d, with energy intake being reduced by a total of 43.8% by wk 24 compared to baseline. Lean muscle mass, fat mass, and fat percentage were reduced (P < 0.0001) by 1.3 kg, 3.1 kg, and 11.7% respectively. Serum triglycerides, alkaline phosphatase, white blood cell counts, and neutrophils were decreased (P < 0.0001), but serum bilirubin, creatinine, and blood urea nitrogen were increased (P < 0.01) over time. Average daily physical activity changed over time, but was not greatly different due to weight loss. Our results suggest that a high-protein, high-fiber diet promotes fat mass loss, minimizes lean muscle mass loss, and reduces inflammatory marker and triglyceride concentrations in overweight dogs. Therefore, it is a suitable nutritional solution for weight loss programs in dogs.

scholarly journals Gut Microbial SNPs Induced by High-Fiber Diet Dominate Nutrition Metabolism and Environmental Adaption of Faecalibacterium prausnitzii in Obese Children

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui Li ◽  
Liping Zhao ◽  
Menghui Zhang
Keyword(s):  
Gut Microbiota ◽  
Human Health ◽  
Dietary Intervention ◽  
Nucleotide Metabolism ◽  
Metagenomic Data ◽  
Snp Analysis ◽  
High Fiber ◽  
Faecalibacterium Prausnitzii ◽  
Fiber Diet ◽  
High Fiber Diet

Dietary intervention is effective in human health promotion through modulation of gut microbiota. Diet can cause single-nucleotide polymorphisms (SNPs) to occur in the gut microbiota, and some of these variations may lead to functional changes in human health. In this study, we performed a systematic SNP analysis based on metagenomic data collected from children with Prader–Willi syndrome (PWS, n = 17) and simple obese (SO) children (n = 19), who had better healthy conditions after receiving high-fiber diet intervention. We found that the intervention increased the SNP proportions of Faecalibacterium, Bifidobacterium, and Clostridium and decreased those of Bacteroides in all children. Besides, the PWS children had Collinsella increased and Ruminococcus decreased, whereas the SO had Blautia and Escherichia decreased. There were much more BiasSNPs in PWS than in SO (4,465 vs 303), and only 81 of them appeared in both groups, of which 78 were from Faecalibacterium prausnitzii, and 51 were nonsynonymous mutations. These nonsynonymous variations were mainly related to pathways of environmental adaptation and nutrition metabolism, particularly to carbohydrate and nucleotide metabolism. In addition, dominant strains carrying BiasSNPs in all children shifted from F. prausnitzii AF32-8AC and F. prausnitzii 942/30-2 to F. prausnitzii SSTS Bg7063 and F. prausnitzii JG BgPS064 after the dietary intervention. Furthermore, although the abundance of Bifidobacterium increased significantly by the intervention and became dominant strains responsible for nutrition metabolism, they had less BiasSNPs between the pre- and post-intervention group in comparison with Faecalibacterium. The finding of F. prausnitzii as important functional strains influenced by the intervention highlights the superiority of applying SNP analysis in studies of gut microbiota. This study provided evidence and support for the effect of dietary intervention on gut microbial SNPs, and gave some enlightenments for disease treatment.

High-fiber diet promotes weight loss and affects maternal behavior in vervet monkeys

2009 ◽  
Vol 72 (3) ◽  
pp. 234-241 ◽  
Author(s):  
Lynn A. Fairbanks ◽  
Karin Blau ◽  
Matthew J. Jorgensen
Keyword(s):  
Weight Loss ◽  
Maternal Behavior ◽  
Vervet Monkeys ◽  
High Fiber ◽  
Fiber Diet ◽  
High Fiber Diet

scholarly journals Microbial enterotypes in personalized nutrition and obesity management

2018 ◽  
Vol 108 (4) ◽  
pp. 645-651 ◽  
Author(s):  
Lars Christensen ◽  
Henrik M Roager ◽  
Arne Astrup ◽  
Mads F Hjorth
Keyword(s):  
Weight Loss ◽  
Gut Microbiota ◽  
Short Chain Fatty Acids ◽  
Dietary Advice ◽  
Obesity Management ◽  
Personalized Nutrition ◽  
High Fiber ◽  
Fiber Diet ◽  
High Fiber Diet ◽  
Weight Loss Strategy

Abstract Human gut microbiota has been suggested to play an important role in nutrition and obesity. However, formulating meaningful and clinically relevant dietary advice based on knowledge about gut microbiota remains a key challenge. A number of recent studies have found evidence that stratification of individuals according to 2 microbial enterotypes (dominance of either Prevotella or Bacteroides) may be useful in predicting responses to diets and drugs. Here, we review enterotypes in a nutritional context and discuss how enterotype stratification may be used in personalized nutrition in obesity management. Enterotypes are characterized by distinct digestive functions with preference for specific dietary substrate, resulting in short-chain fatty acids that may influence energy balance in the host. Consequently, the enterotype potentially affects the individual's ability to lose weight when following a specific diet. In short, a high-fiber diet seems to optimize weight loss among Prevotella-enterotype subjects but not among Bacteroides-enterotype subjects. In contrast, increasing bifidobacteria in the gut among Bacteroides-enterotype subjects improves metabolic parameters, suggesting that this approach can be used as an alternative weight loss strategy. Thus, enterotypes, as a pretreatment gut microbiota biomarker, have the potential to become an important tool in personalized nutrition and obesity management, although further interventions assessing their applicability are warranted.

scholarly journals A High-Fiber Diet Intervention Improves Diet Quality and Is Related to Blood Pressure and Bacteriome Composition in Caregiver-Child Dyads

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1168-1168
Author(s):  
Brett Loman ◽  
Emily Hill ◽  
Michael Bailey ◽  
Jiangjiang Zhu ◽  
Amrik Singh Khalsa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Diet Quality ◽  
Dietary Intervention ◽  
Healthy Eating Index ◽  
Intestinal Microbiome ◽  
Rrna Gene ◽  
High Fiber ◽  
Diet Intervention ◽  
Fiber Diet ◽  
High Fiber Diet

Abstract Objectives High-fiber dietary patterns are associated with cardiovascular health and intestinal microbiome composition. Caregivers influence diets of children, affecting dyadic health and microbiomes. The objectives of this study were to evaluate the relationship between changes in caregiver diet quality and caregiver and child: 1) systolic blood pressure (SBP) and 2) fecal bacteriome composition. Methods Caregiver-child (age 8–9 years) dyads were randomized to either a 10-week high-fiber diet intervention (fruits, vegetables, and whole grains) or control. Caregiver diet quality (30-day FFQs and Healthy Eating Index (HEI)), and caregiver and child SBP and fecal samples were collected pre- and post-intervention. Fecal bacteriomes were analyzed via 16S rRNA gene amplicon sequencing. HEI and SBP were tested via 2-way ANOVA. Bacteriome differentials (i.e., ratio of amplicon sequence variants (ASVs) with related relative abundances) associated with HEI were identified via Songbird and Qurro. Caregiver HEI was used to guide differential assembly in caregiver bacteriomes and as a proxy for child diet quality to guide differential assembly in child bacteriomes. Pearson correlations assessed inter-data relationships. Results Complete data were collected from 19 caregivers and 16 children. Intervention caregivers increased total (T) HEI (+4.4 vs − 1.7 points, P = 0.047) and whole grain (WG) HEI component scores (+1.7 vs 0 points, P = 0.014) compared to control. WG-HEI was correlated with caregiver SBP (r = −0.37, P = 0.046). T-HEI was correlated with caregiver and child T-HEI bacteriome differentials (r = 0.36, P = 0.027 and r = 0.57, P = 0.001). WG-HEI correlated with caregiver and child WG-HEI bacteriome differentials (r = 0.45, P = 0.013 and r = 0.60, P < 0.001). Child WG-HEI differential correlated with child SBP (r = −0.46, P = 0.01). Five ASVs were shared between caregiver and child T-HEI bacteriome differentials, implying shared bacterial responses to intervention. Conclusions A high-fiber dietary intervention positively impacts diet quality and is related to changes in SBP and bacteriome composition in caregiver-child dyads. Metabolites derived from bacterial metabolism of dietary fiber should be investigated for their role in blood pressure. Funding Sources USDA NIFA, Nationwide Children's Hospital.

scholarly journals A High-Protein, High-Fiber Diet Designed for Weight Loss Improves Satiety in Dogs

2007 ◽  
Vol 21 (6) ◽  
pp. 1203-1208 ◽  
Author(s):  
Mickaël Weber ◽  
Thomas Bissot ◽  
Eric Servet ◽  
Renaud Sergheraert ◽  
Vincent Biourge ◽  
...  
Keyword(s):  
Weight Loss ◽  
High Protein ◽  
High Fiber ◽  
Fiber Diet ◽  
High Fiber Diet
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