This study investigated the chemical and nutritional profile and antioxidative properties of cultivated
Coprinus comatus
. Proximate analysis revealed that
C. comatus
is rich in carbohydrates, dietary fibres and proteins, and could also be a valuable source of phenolics. Additionally, fat content is low, consisting mainly of polyunsaturated and omega-3 fatty acids. Furthermore, the safety profile of
C. comatus
is satisfactory, with all elements of toxicological importance within the proposed limits. Oral treatment with
C. comatus
for 42 days improved the antioxidant capabilities and ameliorated carbon tetrachloride-induced liver damage in rats, marked by decreased serum aminotransferase levels and lipid peroxidation intensity. Glutathione concentrations increased in a dose-dependent manner. Histological morphometric and immunohistochemical analysis confirmed antioxidative and hepatoprotective potential. These findings imply that cultivated
C.
comatus
could be considered a nutraceutical, having beneficial nutrient and therapeutic properties.
Antioxidant Properties of Cap and Stipe from Coprinus comatus