Antioxidant properties and antitumor activity of Coprinus comatus

2021 ◽  
Vol 45 (2) ◽  
pp. 77-83
Author(s):  
Hang Hee Cho ◽  
Sun-Hee Jang ◽  
Jae-Hyeon Cho
Keyword(s):  
Antitumor Activity ◽  
Antioxidant Properties ◽  
Coprinus Comatus

scholarly journals Physicochemical and Antioxidant Properties of the Degradations of Polysaccharides from Dendrobium officinale and Their Suitable Molecular Weight Range on Inducing HeLa Cell Apoptosis

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Xiaofeng Zhang ◽  
Yingyi Luo ◽  
Gang Wei ◽  
Yunrong Li ◽  
Yuechun Huang ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Antitumor Activity ◽  
Hela Cells ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Mitochondrial Pathway ◽  
Influential Factor ◽  
Dendrobium Officinale ◽  
Molecular Weight Range ◽  
Pharmaceutical Industries

Different molecular weight polysaccharides of Dendrobium officinale (DOPs) have gradually attracted attention because of their broad biological activities. They, however, remain poorly defined whether their antitumor activity is associated with molecular weight. In this study, the physicochemical, antioxidant, and antitumor properties of DOPs, including the crude polysaccharide (DOP) and its six degradation fractions (DOP1–DOP6) extracted from Dendrobium officinale, were determined. Consequently, DOPs were mainly composed of different ratios of mannose and glucose as follows: 5.15 : 1, 4.62 : 1, 4.19 : 1, 4.46 : 1, 4.32 : 1, 4.29 : 1, and 4.23 : 1, and their molecular weights were significantly different ranging from 652.29 kDa to 11.10 kDa. With the concentration increase of DOPs, the scavenging capacity against OH and DPPH free radicals increased. The antitumor ability of DOPs was different that DOP1–DOP5 (Mw: 176.29 kDa–28.48 kDa) exhibited the best antiproliferation activity than DOP (Mw: 652.29 kDa) and DOP6 (Mw: 11.10 kDa) in HeLa cells rather than PC9, A549, and HepG2 cells. Moreover, it is worth mentioning that DOP1 and DOP5 showed stronger capability on inducing apoptosis of HeLa cells than DOP and DOP6 via the mitochondrial pathway by upregulating the ratio of the Bax/Bal-2 mRNA expression. The results demonstrated that DOPs can be used as the potential natural antioxidant and antitumor products in pharmaceutical industries, and the molecular weight is a crucial influential factor of their antitumor activity that 28.48 kDa–176.29 kDa is a suitable range we may refer to.

scholarly journals Chemical composition, nutritional profile and in vivo antioxidant properties of the cultivated mushroom Coprinus comatus

2020 ◽  
Vol 7 (9) ◽  
pp. 200900
Author(s):  
Nebojša Stilinović ◽  
Ivan Čapo ◽  
Saša Vukmirović ◽  
Aleksandar Rašković ◽  
Ana Tomas ◽  
...  
Keyword(s):  
Oral Treatment ◽  
Antioxidant Properties ◽  
Immunohistochemical Analysis ◽  
Proximate Analysis ◽  
Dependent Manner ◽  
Omega 3 ◽  
Serum Aminotransferase ◽  
Coprinus Comatus ◽  
Nutritional Profile

This study investigated the chemical and nutritional profile and antioxidative properties of cultivated Coprinus comatus . Proximate analysis revealed that C. comatus is rich in carbohydrates, dietary fibres and proteins, and could also be a valuable source of phenolics. Additionally, fat content is low, consisting mainly of polyunsaturated and omega-3 fatty acids. Furthermore, the safety profile of C. comatus is satisfactory, with all elements of toxicological importance within the proposed limits. Oral treatment with C. comatus for 42 days improved the antioxidant capabilities and ameliorated carbon tetrachloride-induced liver damage in rats, marked by decreased serum aminotransferase levels and lipid peroxidation intensity. Glutathione concentrations increased in a dose-dependent manner. Histological morphometric and immunohistochemical analysis confirmed antioxidative and hepatoprotective potential. These findings imply that cultivated C. comatus could be considered a nutraceutical, having beneficial nutrient and therapeutic properties.

scholarly journals Antioxidant Properties of Cap and Stipe from Coprinus comatus

Molecules ◽  
2010 ◽  
Vol 15 (3) ◽  
pp. 1473-1486 ◽  
Author(s):  
Bo Li ◽  
Fei Lu ◽  
Xiaomin Suo ◽  
Haijuan Nan ◽  
Bin Li
Keyword(s):  
Antioxidant Properties ◽  
Coprinus Comatus

710: TNF-Related Apoptosis Inducing Ligand (TRAIL/APO-2L): A Novel Mechanism for BCG-Induced Antitumor Activity

2004 ◽  
Vol 171 (4S) ◽  
pp. 188-189
Author(s):  
Aaron T. Ludwig ◽  
Jill M. Moore ◽  
Yi Luo ◽  
Xiaohong Chen ◽  
Michael A. O’Donnell ◽  
...  
Keyword(s):  
Antitumor Activity

Antioxidant properties of methanol extracts of wild garlics (genus Allium L., sect. Allium)

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
B Bozin ◽  
N Mimica-Dukić ◽  
G Anackov ◽  
B Zlatkovic ◽  
R Igic
Keyword(s):  
Antioxidant Properties ◽  
Methanol Extracts

The effect of the tetracyclines over the antioxidant properties of Chilean native honeys

Planta Medica ◽  
2014 ◽  
Vol 80 (10) ◽  
Author(s):  
E Mejías ◽  
MJ Melo ◽  
G Montenegro
Keyword(s):  
Antioxidant Properties
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