scholarly journals Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines

Molecules ◽  
2013 ◽  
Vol 18 (2) ◽  
pp. 1985-1994 ◽  
Author(s):  
Soek Teh ◽  
Gwendoline Ee ◽  
Siau Mah ◽  
Yang Lim ◽  
Zuraini Ahmad
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Structure Activity Relationships ◽  
Xanthone Derivatives ◽  
Structure Activity

scholarly journals Toxicity and structure-activity relationship (SAR) of α,β-dehydroamino acids against human cancer cell lines

2018 ◽  
Vol 47 ◽  
pp. 26-37 ◽  
Author(s):  
Romeu A. Videira ◽  
Paula B. Andrade ◽  
Luís S. Monteiro ◽  
Patrícia Valentão ◽  
Paula M.T. Ferreira ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Human Cancer Cell ◽  
Dehydroamino Acids ◽  
Human Cancer Cell Lines ◽  
Structure Activity

The Effect of 5-Substitution on the Cytotoxicity of 2-(p-Methoxyphenyl)-1H-Benzimidazoles in Human Cancer Cell Lines

2005 ◽  
Vol 277-279 ◽  
pp. 23-27 ◽  
Author(s):  
Min Jin Kwon ◽  
Hwan Mook Kim ◽  
Dae Duk Kim ◽  
Jung Sun Kim
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Inhibition Activity ◽  
A549 Cell Line ◽  
Human Cancer Cell Lines ◽  
Structure Activity ◽  
Relationship Study

A series of 5-substituted 2-(p-methoxyphenyl)-1H-benzimidazoles was synthesized and evaluated for cytotoxicity against 4 human cancer cell lines, HCT 15, PC-3, A549, and ACHN. Except for the 5-chloro analogue, most of the 5-substituted compounds showed significant cytotoxicities in these cell lines. However, the structure activity relationship study revealed that neither the electronic nor the lipophilic parameters of the 5-substituents were related to cytotoxicity. Moreover, none of the analogues showed significant NF к-β inhibition activity implying that cytotoxicity was not related to this mechanism. The 5-methyl analogue was the most potent compound in this series with a GI50 of 0.9 µM in the A549 cell line.

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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