scholarly journals Novel Flavonol Glycosides from the Aerial Parts of Lentil (Lens culinaris)

Molecules ◽  
2014 ◽  
Vol 19 (11) ◽  
pp. 18152-18178 ◽  
Author(s):  
Jerzy Żuchowski ◽  
Łukasz Pecio ◽  
Anna Stochmal
Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
A Nugroho ◽  
JK Choi ◽  
JH Park ◽  
BC Cha ◽  
HJ Park

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 497
Author(s):  
Jerzy Żuchowski ◽  
Agata Rolnik ◽  
Weronika Adach ◽  
Anna Stochmal ◽  
Beata Olas

While specific metabolites of lentil (Lens culinaris L.) seeds and their biological activity have been well described, other organs of this plant have attracted little scientific attention. In recent years, green parts of lentils have been shown to contain diverse acylated flavonoids. This work presents the results of the research on the effect of the crude extract, the phenolic fraction, and seven flavonoids obtained from aerial parts of lentils on oxidative damage induced by H2O2/Fe to lipid and protein constituents of human plasma. Another goal was to determine their effect on hemostasis parameters of human plasma in vitro. Most of the purified lentil flavonoids had antioxidant and anticoagulant properties. The crude extract and the phenolic fraction of lentil aerial parts showed antioxidant activity, only at the highest tested concentration (50 μg/mL). Our results indicate that aerial parts of lentils may be recommended as a source of bioactive substances.


Heterocycles ◽  
2008 ◽  
Vol 75 (2) ◽  
pp. 419 ◽  
Author(s):  
Kang Ro Lee ◽  
Kyu Ha Lee ◽  
Ki Myun Park ◽  
Kyung Ran Kim ◽  
Jongki Hong ◽  
...  

2019 ◽  
Vol 8 (6) ◽  
pp. 896-907 ◽  
Author(s):  
Magdalena Kluska ◽  
Michał Juszczak ◽  
Daniel Wysokiński ◽  
Jerzy Żuchowski ◽  
Anna Stochmal ◽  
...  

Abstract Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy. In this study, we examined the effect of kaempferol, its derivatives, the polyphenol fraction (PF) and an extract (EX) isolated from the aerial parts of Lens culinaris Medik. on DNA damage induced by etoposide in human cells. We also studied the effect of these compounds and their combinations on cell viability. The studies were conducted on HL-60 cells and human peripheral blood mononuclear cells (PBMCs). We used the comet assay in the alkaline version to evaluate DNA damage. To examine cell viability we applied the trypan blue exclusion assay. We demonstrated that kaempferol glycoside derivatives isolated from the aerial parts of Lens culinaris Medik. reduce DNA damage induced by etoposide in PBMCs, but do not have an impact on DNA damage in HL-60 cells. We also showed that kaempferol induces DNA damage in HL-60 cells and leads to an increase of DNA damage provoked by etoposide. Our data suggest that kaempferol derivatives can be further explored as a potential agent protecting normal cells against DNA damage induced by etoposide. Moreover, kaempferol's ability to induce DNA damage in cancer cells and to increase DNA damage caused by etoposide may be useful in designing and improving anticancer therapies.


2006 ◽  
Vol 21 (1) ◽  
pp. 78-80 ◽  
Author(s):  
Fernando Calzada ◽  
Alma Delia Alanís

2016 ◽  
Vol 39 (9) ◽  
pp. 1232-1236 ◽  
Author(s):  
Hari Jang ◽  
Jin Woo Lee ◽  
Chul Lee ◽  
Qinghao Jin ◽  
Myung Koo Lee ◽  
...  

Molecules ◽  
2013 ◽  
Vol 18 (3) ◽  
pp. 2967-2977 ◽  
Author(s):  
Yi Zhang ◽  
Shen Deng ◽  
Lu Qu ◽  
Ya-Ting An ◽  
Chun-Hua Wu ◽  
...  

1990 ◽  
Vol 34 (2) ◽  
pp. 167-170 ◽  
Author(s):  
Francisco Tomás-Lorente ◽  
Manuela M. García-Grau ◽  
Federico Ferreres ◽  
Francisco A. Tomás-Barberán

1982 ◽  
Vol 37 (4) ◽  
pp. 504-507 ◽  
Author(s):  
Hans Geiger ◽  
Sven Reichert ◽  
Ken R. Markham

Two new flavonol glycosides, herbacetin-and gossypetin-3-β-D-(2-O-β-D-glucopyrano-sidoglucopyranoside)-8-β-D -glucopyranoside have been isolated from the aerial parts of Equisetum hyemale L. together with the known kaempferol-3-β-D-(2-O-β-D-glucopyrano-sidoglucopyranoside) -7-β-D -glucopyranoside.


2021 ◽  
Vol 41 ◽  
pp. 119-122
Author(s):  
Hristo Vasilev ◽  
Karel Šmejkal ◽  
Christian Schulze Gronover ◽  
Young Hae Choi ◽  
Dirk Prüfer ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document