scholarly journals Cannabinoid Delivery Systems for Pain and Inflammation Treatment

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2478 ◽  
Author(s):  
Natascia Bruni ◽  
Carlo Della Pepa ◽  
Simonetta Oliaro-Bosso ◽  
Enrica Pessione ◽  
Daniela Gastaldi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Clinical Trials ◽  
Prescription Drugs ◽  
Delivery Systems ◽  
Controlled Clinical Trials ◽  
Future Directions ◽  
Recent Developments ◽  
Delivery Strategies ◽  
Clinical Conditions ◽  
Transdermal Route

There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such drugs requires well-controlled clinical trials to be carried out in order to objectively establish therapeutic efficacy, dose ranges and safety. The low oral bioavailability of cannabinoids has led to feasible methods of administration, such as the transdermal route, intranasal administration and transmucosal adsorption, being proposed. The highly lipophilic nature of cannabinoids means that they are seen as suitable candidates for advanced nanosized drug delivery systems, which can be applied via a range of routes. Nanotechnology-based drug delivery strategies have flourished in several therapeutic fields in recent years and numerous drugs have reached the market. This review explores the most recent developments, from preclinical to advanced clinical trials, in the cannabinoid delivery field, and focuses particularly on pain and inflammation treatment. Likely future directions are also considered and reported.

scholarly journals Food-Derived Nanoscopic Drug Delivery Systems for Treatment of Rheumatoid Arthritis

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3506
Author(s):  
Dong Han ◽  
Qilei Chen ◽  
Hubiao Chen
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Carriers ◽  
Delivery Systems ◽  
Bioactive Molecules ◽  
Research Orientation ◽  
Therapeutic Outcomes ◽  
Systemic Inflammatory Disease ◽  
Recent Developments

Rheumatoid arthritis (RA) is a severe systemic inflammatory disease with no cure at present. Recent developments in the understanding of inflammation and nanomaterial science have led to increased applications of nanostructured drug delivery systems in the treatment of RA. The present review summarizes novel fabrications of nanoscale drug carriers using food components as either the delivered drugs or carrier structures, in order to achieve safe, effective and convenient drug administration. Polyphenols and flavonoids are among the most frequently carried anti-RA therapeutics in the nanosystems. Fatty substances, polysaccharides, and peptides/proteins can function as structuring agents of the nanocarriers. Frequently used nanostructures include nanoemulsions, nanocapsules, liposomes, and various nanoparticles. Using these nanostructures has improved drug solubility, absorption, biodistribution, stability, targeted accumulation, and release. Joint vectorization, i.e., using a combination of bioactive molecules, can bring elevated therapeutic outcomes. Utilization of anti-arthritic chemicals that can self-assemble into nanostructures is a promising research orientation in this field.

Whey protein: A functional and promising material for drug delivery systems recent developments and future prospects

2019 ◽  
Vol 30 (9) ◽  
pp. 2183-2191 ◽  
Author(s):  
Muhammad Asim Farooq ◽  
Md Aquib ◽  
Sana Ghayas ◽  
Rabia Bushra ◽  
Daulat Haleem Khan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Whey Protein ◽  
Drug Delivery Systems ◽  
Protein A ◽  
Delivery Systems ◽  
Promising Material ◽  
Future Prospects ◽  
Recent Developments

Microneedle-Based Drug Delivery Systems for Transdermal Route

2014 ◽  
Vol 15 (3) ◽  
pp. 281-291 ◽  
Author(s):  
Maria Riemma Pierre ◽  
Fabia Rossetti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Transdermal Route

Development of Drug Targeting and Delivery in Cervical Cancer

2018 ◽  
Vol 18 (8) ◽  
pp. 792-806 ◽  
Author(s):  
Urvashi Aggarwal ◽  
Amit Kumar Goyal ◽  
Goutam Rath
Keyword(s):  
Drug Delivery ◽  
Cervical Cancer ◽  
Side Effects ◽  
Targeted Delivery ◽  
Drug Targeting ◽  
Drug Delivery Systems ◽  
Treatment Options ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Delivery Strategies

Cervical cancer is the second most common cancer in women. Standard treatment options available for cervical cancer include chemotherapy, surgery and radiation therapy associated with their own side effects and toxicities. Tumor-targeted delivery of anticancer drugs is perhaps one of the most appropriate strategies to achieve optimal outcomes from the treatment and improve the quality of life. Recently nanocarriers based drug delivery systems owing to their unique properties have been extensively investigated for anticancer drug delivery. In addition to that addressing the anatomical significance of cervical cancer, various local drug delivery strategies for the cancer treatment are introduced like: gels, nanoparticles, polymeric films, rods and wafers, lipid based nanocarrier. Localized drug delivery systems allow passive drug targeting results in high drug concentration at the target site. Further they can be tailor made to achieve both sustained and controlled release behavior, substantially improving therapeutic outcomes and minimizing side effects. This review summarizes the meaningful advances in drug delivery strategies to treat cervical cancer.

Nanoparticle-Based Drug Delivery Systems for Cardiovascular Applications

2019 ◽  
pp. 499-508
Author(s):  
Arti Patel ◽  
Yashwant V. Pathak
Keyword(s):  
Myocardial Infarction ◽  
Drug Delivery ◽  
Clinical Trials ◽  
Drug Delivery Systems ◽  
Controlled Drug Release ◽  
Delivery Systems ◽  
Delivery Methods ◽  
Specific Targeting ◽  
Nanoparticle Drug Delivery ◽  
Treatment And Diagnosis

Nanomedicine has vastly improved the treatment and diagnosis of many cardiovascular conditions such as atherosclerosis, myocardial ischemia, myocardial infarction, restenosis, and thrombosis. A few nanoparticle drug delivery systems that are currently being tested and used in clinical trials include lipid-based drug delivery, controlled drug release, and specific targeting. The chapter describes the various drug delivery methods, the various nanoparticles, and their application on specific cardiovascular conditions. This chapter compiles examples of specific clinical trials that are being conducted, using nanoparticles for therapy of cardiovascular conditions.

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