scholarly journals Recent Development of pH-Responsive Polymers for Cancer Nanomedicine

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 4 ◽  
Author(s):  
Houliang Tang ◽  
Weilong Zhao ◽  
Jinming Yu ◽  
Yang Li ◽  
Chao Zhao
Keyword(s):  
Cancer Diagnosis ◽  
Anticancer Agents ◽  
Rational Design ◽  
Polymeric Materials ◽  
Diagnosis And Treatment ◽  
Structure Property ◽  
Ph Responsive ◽  
Chemical Structures ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. This review article aims to provide general guidelines for the rational design of more effective pH-responsive nanomaterials for cancer diagnosis and treatment.

scholarly journals MAGNETIC AND pH SENSITIVE NANOPARTICLES FOR CANCER DRUG DELIVERY

1970 ◽  
Vol 7 (4) ◽  
pp. 60-71
Author(s):  
Amol G Jadhao ◽  
Akashy G Bhosale ◽  
G R Sitaphale ◽  
Jeevan R Rajguru ◽  
Sonali A Sonali ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Polymeric Materials ◽  
Therapeutic Index ◽  
The Body ◽  
Cancer Drug ◽  
Structure Property ◽  
Ph Responsive ◽  
Chemical Structures ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

Cancer remains a leading cause of death worldwide with more than 10 million new cases every year. Tumor-targeted nanomedicines have shown substantial improvements of the therapeutic index of anticancer agents, addressing the deficiencies of conventional chemotherapy, and have had a tremendous growth over past several decades. Due to the pathophysiological characteristics that almost all tumor tissues have lower pH in comparison to normal healthy tissues, among various tumor-targeted nanomaterials, pH-responsive polymeric materials have been one of the most prevalent approaches for cancer diagnosis and treatment. In this review, we summarized the types of pH-responsive polymers, describing their chemical structures and pH-response mechanisms; we illustrated the structure-property relationships of pH-responsive polymers and introduced the approaches to regulating their pH-responsive behaviors; we also highlighted the most representative applications of pH-responsive polymers in cancer imaging and therapy. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment.  

Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications

2017 ◽  
Vol 253 ◽  
pp. 46-63 ◽  
Author(s):  
Salime Bazban-Shotorbani ◽  
Mohammad Mahdi Hasani-Sadrabadi ◽  
Akbar Karkhaneh ◽  
Vahid Serpooshan ◽  
Karl I Jacob ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Structure Property ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Property Relationship ◽  
Structure Property Relationship ◽  
Drug Delivery Applications ◽  
Ph Responsive Polymers ◽  
Relationship Of

A General Method for the Synthesis and Isolation of Well-Defined Core Cross-Linked Multistar Assemblies: A Route toward Enhanced pH-Responsive Polymers

2009 ◽  
Vol 42 (13) ◽  
pp. 4622-4631 ◽  
Author(s):  
Jing Fung Tan ◽  
Anton Blencowe ◽  
Tor Kit Goh ◽  
Irving Ted M. Dela Cruz ◽  
Greg G. Qiao
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Ph Responsive Polymers ◽  
General Method

The Effects of Substituent Grafting on the Interaction of pH-Responsive Polymers with Phospholipid Monolayers

Langmuir ◽  
2011 ◽  
Vol 27 (13) ◽  
pp. 8530-8539 ◽  
Author(s):  
Shengwen Zhang ◽  
Andrew Nelson ◽  
Zachary Coldrick ◽  
Rongjun Chen
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Phospholipid Monolayers ◽  
Ph Responsive Polymers

Graft modification of starch nanoparticles with pH‐responsive polymers via nitroxide‐mediated polymerization

2020 ◽  
Vol 58 (16) ◽  
pp. 2211-2220
Author(s):  
Jaime C. Cazotti ◽  
Alexander T. Fritz ◽  
Omar Garcia‐Valdez ◽  
Niels M. B. Smeets ◽  
Marc A. Dubé ◽  
...  
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Graft Modification ◽  
Starch Nanoparticles ◽  
Ph Responsive Polymers ◽  
Nitroxide Mediated Polymerization

pH-Responsive Polymers: Properties, Synthesis, and Applications

2019 ◽  
pp. 45-86
Author(s):  
Luis García-Fernández ◽  
Ana Mora-Boza ◽  
Felisa Reyes-Ortega
Keyword(s):  
Ph Responsive ◽  
Responsive Polymers ◽  
Ph Responsive Polymers

scholarly journals Control of targeting ligand display by pH-responsive polymers on gold nanoparticles mediates selective entry into cancer cells

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11137-11147 ◽  
Author(s):  
C. Brazzale ◽  
F. Mastrotto ◽  
P. Moody ◽  
P. D. Watson ◽  
A. Balasso ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cell Uptake ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Nanoparticle Surface ◽  
Site Selectivity ◽  
Ph Responsive Polymers

The pH-triggered display of targeting agent on nanoparticle surface controls cancer cell uptake. This enhances site-selectivity of nanosystems.

scholarly journals Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 1870 ◽  
Author(s):  
Haiming Fan ◽  
Po Li ◽  
Wei Li ◽  
Hui Li ◽  
Xiaonan Huang
Keyword(s):  
Hydrophobic Effect ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Ph Responsive ◽  
Responsive Polymers ◽  
Novel Approach ◽  
Pka Value ◽  
Methacrylate Monomers ◽  
Amine Groups ◽  
Ph Responsive Polymers

Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials.

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