scholarly journals Bodiniosides S–Y, Seven New Triterpenoid Saponins from Elsholtzia bodinieri and Their Anti-Influenza Activities

Molecules ◽  
2021 ◽  
Vol 26 (21) ◽  
pp. 6535
Author(s):  
Linyao Yang ◽  
Jiangchao Du ◽  
Rongtao Li ◽  
Fei Yu ◽  
Jindong Zhong
Keyword(s):  
Acid Hydrolysis ◽  
H1n1 Virus ◽  
Mdck Cells ◽  
Spectroscopic Techniques ◽  
Triterpenoid Saponins ◽  
Gc Analysis ◽  
Aerial Parts ◽  
2009 H1n1

Investigation of the n-BuOH extract of the aerial parts of Elsholtzia bodinieri led to the isolation of seven new triterpenoid saponins, Bodiniosides S–Y (1–7, resp.). Their strictures were elucidated on the basis of spectroscopic techniques, including HSQC, HSBC, and HSQC–TOCSY experiments, together with acid hydrolysis and GC analysis. The anti-influenza activities of compounds 1–7 were evaluated against A/WSN/33/2009 (H1N1) virus in MDCK cells. The results showed that compounds 2 and 5 exhibited moderate anti-influenza activities against A/WSN/33/2009 (H1N1), with inhibition rates of 35.33% and 24.08%, respectively.

Five New Oleanane Triterpenoid Saponins from the Aerial Parts ofElsholtzia bodinieri

2016 ◽  
pp. n/a-n/a
Author(s):  
Jin-Dong Zhong ◽  
Xue-Wei Zhao ◽  
Hong-Mei Li ◽  
Ling-Huan Gao ◽  
Rong-Tao Li
Keyword(s):  
Triterpenoid Saponins ◽  
Aerial Parts ◽  
Oleanane Triterpenoid

Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets

Vaccine ◽  
2011 ◽  
Vol 29 (16) ◽  
pp. 2887-2894 ◽  
Author(s):  
Melissa B. Pearce ◽  
Jessica A. Belser ◽  
Katherine V. Houser ◽  
Jacqueline M. Katz ◽  
Terrence M. Tumpey
Keyword(s):  
Influenza Vaccine ◽  
Virus Replication ◽  
H1n1 Virus ◽  
Live Attenuated Influenza Vaccine ◽  
2009 H1n1

scholarly journals Subcutaneous Immunization with Baculovirus Surface-Displayed Hemagglutinin of Pandemic H1N1 Influenza A Virus Induces Protective Immunity in Mice

2011 ◽  
Vol 18 (9) ◽  
pp. 1582-1585 ◽  
Author(s):  
Mookkan Prabakaran ◽  
Tao Meng ◽  
Fang He ◽  
Tan YunRui ◽  
Jia Qiang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Protective Immunity ◽  
Influenza A ◽  
H1n1 Virus ◽  
H1n1 Influenza ◽  
Influenza Virus Hemagglutinin ◽  
Inactive Form ◽  
2009 H1n1 ◽  
Subcutaneous Immunization ◽  
H1n1 Virus Infection

ABSTRACTThe protective immunity of baculovirus displaying influenza virus hemagglutinin (BacHA) against influenza 2009 H1N1 virus infection in a murine model was investigated. The results showed that mice vaccinated with live BacHA or an inactive form of adjuvanted BacHA had enhanced specific antibody responses and induced protective immunity against 2009 H1N1 virus infection, suggesting the potential of baculovirus as a live or inactivated vaccine.

scholarly journals Histopathological and immunohistochemical findings of 20 autopsy cases with 2009 H1N1 virus infection

2011 ◽  
Vol 25 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Noriko Nakajima ◽  
Yuko Sato ◽  
Harutaka Katano ◽  
Hideki Hasegawa ◽  
Toshio Kumasaka ◽  
...  
Keyword(s):  
Virus Infection ◽  
H1n1 Virus ◽  
2009 H1n1 ◽  
H1n1 Virus Infection

Antifungal activity and cytotoxicity of extracts and triterpenoid saponins obtained from the aerial parts of Anagallis arvensis L.

2017 ◽  
Vol 203 ◽  
pp. 233-240 ◽  
Author(s):  
José R. Soberón ◽  
Melina A. Sgariglia ◽  
Ana C. Pastoriza ◽  
Estela M. Soruco ◽  
Sebastián N. Jäger ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Triterpenoid Saponins ◽  
Aerial Parts

scholarly journals Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus

2020 ◽  
Vol 165 (11) ◽  
pp. 2503-2512
Author(s):  
S. Ketklao ◽  
C. Boonarkart ◽  
S. Phakaratsakul ◽  
P. Auewarakul ◽  
Ornpreya Suptawiwat
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
Antigenic Drift ◽  
2009 H1n1

Clinical and Microbiologic Features Associated With Novel Swine-Origin Influenza A Pandemic 2009 (H1N1) Virus in Children

2010 ◽  
Vol 29 (8) ◽  
pp. 694-698 ◽  
Author(s):  
Penelope A. Bryant ◽  
Marc Tebruegge ◽  
Georgina Papadakis ◽  
Caroline Clarke ◽  
Peter Barnett ◽  
...  
Keyword(s):  
Influenza A ◽  
H1n1 Virus ◽  
2009 H1n1

scholarly journals Isolation and Quantification of Pinitol, a Bioactive Cyclitol, in Retama spp

2016 ◽  
Vol 11 (3) ◽  
pp. 1934578X1601100 ◽  
Author(s):  
Nuria H. González-Mauraza ◽  
Antonio J. León-González ◽  
José L. Espartero ◽  
Juan B. Gallego-Fernández ◽  
Marina Sánchez-Hidalgo ◽  
...  
Keyword(s):  
Mediterranean Region ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Aqueous Extracts ◽  
Aerial Parts ◽  
The Mediterranean ◽  
Anti Inflammatory ◽  
Identification And Quantification

The genus Retama (Fabaceae) is widely distributed in the Mediterranean region. In the present study, pinitol (3- O-methyl- chiro-inositol), an anti-inflammatory and antidiabetic molecule, was isolated from aerial parts of R. monosperma, and its structure established on the basis of spectroscopic techniques (1D/2D NMR) and MS. Identification and quantification of pinitol in R. raetam and R. sphaerocarpa were also performed. R. monosperma had the highest concentration of pinitol (2.3%). The presence of pinitol in aqueous extracts of Retama spp. may explain the adaptation of these plants to drought and salinity. Furthermore, pinitol could be considered as a mediator in the anti-inflammatory and hypoglycemic activities of Retama spp., which are traditionally used to treat diabetes.

scholarly journals Three New Cytotoxic Withanolides from the Chinese Folk Medicine Physalis angulata

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Cai-Yun Gao ◽  
Ting Ma ◽  
Jun Luo ◽  
Ling-Yi Kong
Keyword(s):  
Cell Line ◽  
Folk Medicine ◽  
2D Nmr ◽  
Cytotoxic Activities ◽  
Spectroscopic Techniques ◽  
Aerial Parts ◽  
Physalis Angulata ◽  
The Absolute ◽  
New Compounds

Physagulides M-O, three new withanolides (1–3), were isolated from the aerial parts of Physalis angulata L. Their structures were elucidated through extensive spectroscopic techniques, including 1D and 2D NMR, and HRESIMS. The absolute configurations (22- R) of these new compounds were determined by CD analysis. Compounds 1 and 3 showed significant selective cytotoxic activities on the MG-63 cell line, with IC50 values of 4.28 and 5.44 μM, respectively.

Dammarane triterpenoid saponins from Bacopa monnieri

2009 ◽  
Vol 87 (9) ◽  
pp. 1230-1234 ◽  
Author(s):  
Pamita Bhandari ◽  
Neeraj Kumar ◽  
Bikram Singh ◽  
Inderjeet Kaur
Keyword(s):  
Medicinal Plant ◽  
2D Nmr ◽  
Bacopa Monnieri ◽  
Spectroscopic Methods ◽  
Triterpenoid Saponins ◽  
Enhancing Effect ◽  
Indian Medicinal Plant ◽  
Aerial Parts ◽  
Memory Enhancer ◽  
Memory Enhancing

Bacopa monnieri is a well-known Ayurvedic Indian medicinal plant traditionally used as a memory enhancer. Its memory-enhancing effect is mainly attributed to dammarane triterpenoid saponins. In the present study, two new dammarane-type triterpenoid saponins, bacopaside-XI (1) and bacopaside-XII (2), together with known compounds, bacopaside IV, bacopaside V, and apigenin, were isolated from the aerial parts of the B. monnieri . The structures of the new saponins were elucidated as 3-O-[α-L-arabinofuranosyl(1→3)]-6-O-sulfonyl-β-D-glucopyranosyl pseudojujubogenin (1) and 3-O-{β-D-glucopyranosyl(1→3)[α-L-arabinofuranosyl(1→2)]-β-D-glucopyranosyl}-20-O-α-L-arabinopyranosyl pseudojujubogenin (2) on the basis of extensive investigations of 1D and 2D NMR (HMQC and HMBC), ESI-QTOF-MS/MS spectroscopic methods, and chemical evidences.

Sign in / Sign up

Export Citation Format

Share Document