scholarly journals Resveratrol Promotes Angiogenesis in a FoxO1-Dependent Manner in Hind Limb Ischemia in Mice

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7528
Author(s):  
Dongxiao Fan ◽  
Chenshu Liu ◽  
Zeling Guo ◽  
Kan Huang ◽  
Meixiu Peng ◽  
...  

Critical limb ischemia (CLI) is a severe form of peripheral artery diseases (PAD) and seriously endangers the health of people. Therapeutic angiogenesis represents an important treatment strategy for CLI; various methods have been applied to enhance collateral circulation. However, the current development drug therapy to promote angiogenesis is limited. Resveratrol (RSV), a polyphenol compound extracted from plants, has various properties such as anti-oxidative, anti-inflammatory and anti-cancer effects. Whether RSV exerts protective effects on CLI remains elusive. In the current study, we demonstrated that oral intake of RSV significantly improved hind limb ischemia in mice, and increased the expression of phosphorylated Forkhead box class-O1 (FoxO1). RSV treatment in human umbilical vein endothelial cells (HUVECs) could increase the phosphorylation of FoxO1 and its cytoplasmic re-localization to promote angiogenesis. Then we manipulated FoxO1 in HUVECs to further verify that the effect of RSV on angiogenesis is in a FoxO1-dependent manner. Furthermore, we performed metabolomics to screen the metabolic pathways altered upon RSV intervention. We found that the pathways of pyrimidine metabolism, purine metabolism, as well as alanine, aspartate and glutamate metabolism, were highly correlated with the beneficial effects of RSV on the ischemic muscle. This study provides a novel direction for the medical therapy to CLI.

2012 ◽  
Vol 55 (6) ◽  
pp. 18S-19S
Author(s):  
Robert Brenes ◽  
Caroline C. Jadlowiec ◽  
Mackenzie Bear ◽  
Peter Hashim ◽  
Clinton D. Protack ◽  
...  

2011 ◽  
Vol 213 (3) ◽  
pp. S101-S102
Author(s):  
Robert A. Brenes ◽  
Mackenzie Bear ◽  
Caroline Jadlowiec ◽  
Peter Hashim ◽  
Juan A. Sanchez ◽  
...  

2009 ◽  
Vol 51 (4) ◽  
pp. 268-274 ◽  
Author(s):  
Zijiang Yang ◽  
Moritz Wyler von Ballmoos ◽  
Nicolas Diehm ◽  
Iris Baumgartner ◽  
Christoph Kalka ◽  
...  

Stem Cells ◽  
2008 ◽  
Vol 26 (10) ◽  
pp. 2625-2633 ◽  
Author(s):  
Shin Ishikane ◽  
Shunsuke Ohnishi ◽  
Kenichi Yamahara ◽  
Masaharu Sada ◽  
Kazuhiko Harada ◽  
...  

Circulation ◽  
2004 ◽  
Vol 109 (4) ◽  
pp. 526-531 ◽  
Author(s):  
Noriyuki Tokunaga ◽  
Noritoshi Nagaya ◽  
Mikiyasu Shirai ◽  
Etsuro Tanaka ◽  
Hatsue Ishibashi-Ueda ◽  
...  

2016 ◽  
Vol 24 ◽  
pp. S178 ◽  
Author(s):  
Pavel I. Makarevich ◽  
Maria A. Boldyreva ◽  
Anastasia Yu. Efimenko ◽  
Evgeny V. Gluhanyuk ◽  
Konstantin V. Dergilev ◽  
...  

2016 ◽  
Vol 5 (9) ◽  
pp. 1008-1013 ◽  
Author(s):  
Subhamoy Das ◽  
Anthony J. Monteforte ◽  
Gunjan Singh ◽  
Marjan Majid ◽  
Michael B. Sherman ◽  
...  

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