scholarly journals Current Photoactive Molecules for Targeted Therapy of Triple-Negative Breast Cancer

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7654
Author(s):  
Cristina J. Dias ◽  
Luisa Helguero ◽  
Maria Amparo F. Faustino
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Targeted Therapy ◽  
Survival Rate ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Photothermal Therapy ◽  
Triple Negative ◽  
Therapeutic Window ◽  
Specific Targeting

Cancer is the second leading cause of death worldwide; therefore, there is an urgent need to find safe and effective therapies. Triple-negative breast cancer (TNBC) is diagnosed in ca. 15–20% of BC and is extremely aggressive resulting in reduced survival rate, which is mainly due to the low therapeutic efficacy of available treatments. Photodynamic therapy (PDT) is an interesting therapeutic approach in the treatment of cancer; the photosensitizers with good absorption in the therapeutic window, combined with their specific targeting of cancer cells, have received particular interest. This review aims to revisit the latest developments on chlorin-based photoactive molecules for targeted therapy in TNBC. Photodynamic therapy, alone or combined with other therapies (such as chemotherapy or photothermal therapy), has potential to be a safe and a promising approach against TNBC.

scholarly journals Evaluating Nanoshells and a Potent Biladiene Photosensitizer for Dual Photothermal and Photodynamic Therapy of Triple Negative Breast Cancer Cells

Nanomaterials ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 658 ◽  
Author(s):  
Rachel Riley ◽  
Rachel O’Sullivan ◽  
Andrea Potocny ◽  
Joel Rosenthal ◽  
Emily Day
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Gold Shell ◽  
Cancer Cell Death ◽  
Silica Core

Light-activated therapies are ideal for treating cancer because they are non-invasive and highly specific to the area of light application. Photothermal therapy (PTT) and photodynamic therapy (PDT) are two types of light-activated therapies that show great promise for treating solid tumors. In PTT, nanoparticles embedded within tumors emit heat in response to laser light that induces cancer cell death. In PDT, photosensitizers introduced to the diseased tissue transfer the absorbed light energy to nearby ground state molecular oxygen to produce singlet oxygen, which is a potent reactive oxygen species (ROS) that is toxic to cancer cells. Although PTT and PDT have been extensively evaluated as independent therapeutic strategies, they each face limitations that hinder their overall success. To overcome these limitations, we evaluated a dual PTT/PDT strategy for treatment of triple negative breast cancer (TNBC) cells mediated by a powerful combination of silica core/gold shell nanoshells (NSs) and palladium 10,10-dimethyl-5,15-bis(pentafluorophenyl)biladiene-based (Pd[DMBil1]-PEG750) photosensitizers (PSs), which enable PTT and PDT, respectively. We found that dual therapy works synergistically to induce more cell death than either therapy alone. Further, we determined that low doses of light can be applied in this approach to primarily induce apoptotic cell death, which is vastly preferred over necrotic cell death. Together, our results show that dual PTT/PDT using silica core/gold shell NSs and Pd[DMBil1]-PEG750 PSs is a comprehensive therapeutic strategy to non-invasively induce apoptotic cancer cell death.

Ruthenium(ii) complexes as bioorthogonal two-photon photosensitizers for tumour-specific photodynamic therapy against triple-negative breast cancer cells

2021 ◽  
Author(s):  
Mingwei Lin ◽  
Shanshan Zou ◽  
Xinxing Liao ◽  
Yu Chen ◽  
Diqing Luo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Two Photon

We developed the first Ru(ii) complex-based bioorthogonal two-photon photosensitizers. Through bioorthogonal labelling, they realize effective tumour-specific photodynamic therapy against triple-negative breast cancer cells.

Supramolecular magnetonanohybrids for multimodal targeted therapy of triple-negative breast cancer cells

2020 ◽  
Vol 8 (32) ◽  
pp. 7166-7188 ◽  
Author(s):  
Alexandra A. P. Mansur ◽  
Herman S. Mansur ◽  
Alice G. Leonel ◽  
Isadora C. Carvalho ◽  
Manuela C. G. Lage ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative

All-in-one nanosoldier on a targeted mission: killing the triple-negative breast cancer cell enemy.

scholarly journals Supramolecular core–glycoshell polythiophene nanodots for targeted imaging and photodynamic therapy

2017 ◽  
Vol 53 (70) ◽  
pp. 9793-9796 ◽  
Author(s):  
Hai-Hao Han ◽  
Chang-Zheng Wang ◽  
Yi Zang ◽  
Jia Li ◽  
Tony D. James ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Targeted Imaging

We show that supramolecular core–glycoshell nanodots are capable of targeted imaging and photodynamic therapy of liver and triple-negative breast cancer cells.

Near infrared light-actuated gold nanorods with cisplatin–polypeptide wrapping for targeted therapy of triple negative breast cancer

Nanoscale ◽  
2015 ◽  
Vol 7 (36) ◽  
pp. 14854-14864 ◽  
Author(s):  
Bing Feng ◽  
Zhiai Xu ◽  
Fangyuan Zhou ◽  
Haijun Yu ◽  
Qianqian Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Targeted Therapy ◽  
Triple Negative Breast Cancer ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Triple Negative ◽  
Infrared Light ◽  
Near Infrared Light

Gold nanorods with cisplatin–polypeptide wrapping were developed for combinational photothermal therapy and chemotherapy of triple negative breast cancer.

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