Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects

The complexity of some diseases—as well as the inherent toxicity of certain drugs—has led to an increasing interest in the development and optimization of drug-delivery systems. Polymeric nanoparticles stand out as a key tool to improve drug bioavailability or specific delivery at the site of action. The versatility of polymers makes them potentially ideal for fulfilling the requirements of each particular drug-delivery system. In this review, a summary of the state-of-the-art panorama of polymeric nanoparticles as drug-delivery systems has been conducted, focusing mainly on those applications in which the corresponding disease involves an important morbidity, a considerable reduction in the life quality of patients—or even a high mortality. A revision of the use of polymeric nanoparticles for ocular drug delivery, for cancer diagnosis and treatment, as well as nutraceutical delivery, was carried out, and a short discussion about future prospects of these systems is included.

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Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review

Pharmaceutics ◽

10.3390/pharmaceutics12121232 ◽

2020 ◽

Vol 12 (12) ◽

pp. 1232

Author(s):

Mohammadmahdi Mobaraki ◽

Madjid Soltani ◽

Samaneh Zare Harofte ◽

Elham L. Zoudani ◽

Roshanak Daliri ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems ◽

Sense Organs ◽

Drug Bioavailability ◽

Controllable Release ◽

The World ◽

Pros And Cons ◽

Different Parts

During recent decades, researchers all around the world have focused on the characteristic pros and cons of the different drug delivery systems for cornea tissue change for sense organs. The delivery of various drugs for cornea tissue is one of the most attractive and challenging activities for researchers in biomaterials, pharmacology, and ophthalmology. This method is so important for cornea wound healing because of the controllable release rate and enhancement in drug bioavailability. It should be noted that the delivery of various kinds of drugs into the different parts of the eye, especially the cornea, is so difficult because of the unique anatomy and various barriers in the eye. Nanoparticles are investigated to improve drug delivery systems for corneal disease. Biodegradable nanocarriers for repeated corneal drug delivery is one of the most attractive and challenging methods for corneal drug delivery because they have shown acceptable ability for this purpose. On the other hand, by using these kinds of nanoparticles, a drug could reside in various part of the cornea for longer. In this review, we summarized all approaches for corneal drug delivery with emphasis on the biodegradable nanoparticles, such as liposomes, dendrimers, polymeric nanoparticles, niosomes, microemulsions, nanosuspensions, and hydrogels. Moreover, we discuss the anatomy of the cornea at first and gene therapy at the end.

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Whey protein: A functional and promising material for drug delivery systems recent developments and future prospects

Polymers for Advanced Technologies ◽

10.1002/pat.4676 ◽

2019 ◽

Vol 30 (9) ◽

pp. 2183-2191 ◽

Cited By ~ 2

Author(s):

Muhammad Asim Farooq ◽

Md Aquib ◽

Sana Ghayas ◽

Rabia Bushra ◽

Daulat Haleem Khan ◽

...

Keyword(s):

Drug Delivery ◽

Whey Protein ◽

Drug Delivery Systems ◽

Protein A ◽

Delivery Systems ◽

Promising Material ◽

Future Prospects ◽

Recent Developments

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Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Advanced Pharmaceutical Bulletin ◽

10.34172/apb.2022.006 ◽

2021 ◽

Author(s):

Unnati Garg ◽

Karuna Jain

Keyword(s):

Drug Delivery ◽

Transdermal Drug Delivery ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems ◽

Particle Systems ◽

Drug Bioavailability ◽

Preparation Methods ◽

Solvent Extraction Method ◽

Feasible Option

Transdermal delivery over the past decade has become the field of interest for drug delivery due to its various advantages such as no first-pass metabolism, increased drug bioavailability, and easy administration. Different vesicle systems like ethosomes, liposomes, niosomes, and transferosomes along with particle systems like lipid nanoparticles, polymeric nanoparticles, carbon nanotubes, and fullerenes have been developed. These vesicles and particle systems have been developed using various easy and effective methods like cold injection method, rotary film evaporation, thin film hydration, high shear homogenization, solvent extraction method, and many more. These drug delivery systems are a very effective and feasible option for transdermal drug delivery and further developments can be made to increase their use. This article explains in detail the preparation methods and applications for these drug delivery systems.

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Nano based drug delivery systems: recent developments and future prospects

Journal of Nanobiotechnology ◽

10.1186/s12951-018-0392-8 ◽

2018 ◽

Vol 16 (1) ◽

Cited By ~ 548

Author(s):

Jayanta Kumar Patra ◽

Gitishree Das ◽

Leonardo Fernandes Fraceto ◽

Estefania Vangelie Ramos Campos ◽

Maria del Pilar Rodriguez-Torres ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Future Prospects ◽

Recent Developments

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Nanotechnology Advanced Strategies for the Management of Diabetes Mellitus

Current Drug Targets ◽

10.2174/1389450120666190307101642 ◽

2019 ◽

Vol 20 (10) ◽

pp. 995-1007 ◽

Cited By ~ 1

Author(s):

Amira Mohamed Mohsen

Keyword(s):

Diabetes Mellitus ◽

Drug Delivery ◽

Drug Targeting ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Artificial Pancreas ◽

Delivery Systems ◽

The Novel ◽

Site Of Action ◽

Treatment Of Diabetes

Background:Medications currently available for the management of diabetes mellitus are inconvenient and have some limitations. Thus, investigations for novel approaches are needed to deliver and target antidiabetics safely to the site of action.Objective:The present review emphasizes the limitations of conventional antidiabetics and provides the recent progresses of nanotechnology in the treatment of diabetes mellitus with a special highlight on the novel nanocarriers methodologies employed as antidiabetic drug delivery systems.Methods:The potential nanocarriers employed for the treatment of diabetes comprise liposomes, niosomes, self-nanoemulsifying drug delivery systems, polymeric nanoparticles, gold nanoparticles, dendrimers and micelles. Herbal nanomedicine has also emerged to be a promising way for adequate delivery of herbal compounds. Other nanotechnology approaches involve the usage of oral insulin, inhalable insulin, artificial pancreas, and nanopump.Results:Nanocarriers have proved to lead a successful delivery of antidiabetic medications, aiming at drug targeting for enhanced efficacy and safety.Conclusion:These innovative generations of drug delivery systems have important benefits over conventionally existing ones. The future of nanotechnology in the management of diabetes is still open with several prospects and will be of pronounced significance.

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Pulmonary Drug Delivery Systems: Recent Developments and Prospects;

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v19.i45.40 ◽

2002 ◽

Vol 19 (4-5) ◽

pp. 425-498 ◽

Cited By ~ 185

Author(s):

H. M. Courrier ◽

N. Butz ◽

Th. F. Vandamme

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Pulmonary Drug Delivery ◽

Recent Developments

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Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00431 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1039

Author(s):

Yang YANG ◽

Wen-Chuan SHE ◽

Kui LUO ◽

Zhong-Wei GU

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems

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Towards feedback-controlled nanomedicines for smart, adaptive delivery

Experimental Biology and Medicine ◽

10.1177/1535370218800456 ◽

2018 ◽

Vol 244 (4) ◽

pp. 283-293 ◽

Cited By ~ 4

Author(s):

Stephen J. Jones ◽

Annette F. Taylor ◽

Paul A Beales

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery Systems ◽

Delivery Systems ◽

The Body ◽

Living Systems ◽

Prolonged Release ◽

Drug Bioavailability ◽

Drug Release Profile ◽

Chemical Systems

Nanomedicines for controlled drug release provide temporal and spatial regulation of drug bioavailability in the body. The timing of drug release is usually engineered either for slow gradual release over an extended period of time or for rapid release triggered by a specific change in its physicochemical environment. However, between these two extremes, there is the desirable possibility of adaptive nanomedicines that dynamically modulate drug release in tune with its changing environment. Adaptation and response through communication with its environment is a fundamental trait of living systems; therefore, the design of biomimetic nanomedicines through the approaches of bottom-up synthetic biology provides a viable route to this goal. This could enable drug delivery systems to optimize release in synchronicity with the body’s natural biological rhythms and the personalized physiological characteristics of the patient, e.g. their metabolic rate. Living systems achieve this responsiveness through feedback-controlled biochemical processes that regulate their functional outputs. Towards this goal of adaptive drug delivery systems, we review the general benefits of nanomedicine formulations, provide existing examples of experimental nanomedicines that encapsulate the metabolic function of enzymes, and give relevant examples of feedback-controlled chemical systems. These are the underpinning concepts that hold promise to be combined to form novel adaptive release systems. Furthermore, we motivate the advantages of adaptive release through chronobiological examples. By providing a brief review of these topics and an assessment of the state of the art, we aim to provide a useful resource to accelerate developments in this field. Impact statement The timing and rate of release of pharmaceuticals from advanced drug delivery systems is an important property that has received considerable attention in the scientific literature. Broadly, these mostly fall into two classes: controlled release with a prolonged release rate or triggered release where the drug is rapidly released in response to an environmental stimulus. This review aims to highlight the potential for developing adaptive release systems that more subtlety modulate the drug release profile through continuous communication with its environment facilitated through feedback control. By reviewing the key elements of this approach in one place (fundamental principles of nanomedicine, enzymatic nanoreactors for medical therapies and feedback-controlled chemical systems) and providing additional motivating case studies in the context of chronobiology, we hope to inspire innovative development of novel “chrononanomedicines.”

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