scholarly journals Biosensing Using SERS Active Gold Nanostructures

Nanomaterials ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2679
Author(s):  
Gour Mohan Das ◽  
Stefano Managò ◽  
Maria Mangini ◽  
Anna Chiara De De Luca
Keyword(s):  
High Sensitivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
Fingerprint Recognition ◽  
Chemical Enhancement ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sensor Configuration ◽  
Relevant Factors ◽  
Selection Of

Surface-enhanced Raman spectroscopy (SERS) has become a powerful tool for biosensing applications owing to its fingerprint recognition, high sensitivity, multiplex detection, and biocompatibility. This review provides an overview of the most significant aspects of SERS for biomedical and biosensing applications. We first introduced the mechanisms at the basis of the SERS amplifications: electromagnetic and chemical enhancement. We then illustrated several types of substrates and fabrication methods, with a focus on gold-based nanostructures. We further analyzed the relevant factors for the characterization of the SERS sensor performances, including sensitivity, reproducibility, stability, sensor configuration (direct or indirect), and nanotoxicity. Finally, a representative selection of applications in the biomedical field is provided.

Physically Self-assembled Au Nanorod Arrays for SERS

2006 ◽  
Vol 951 ◽  
Author(s):  
Motofumi Suzuki ◽  
Kaoru Nakajima ◽  
Kenji Kimura ◽  
Takao Fukuoka ◽  
Yasushige Mori
Keyword(s):  
Raman Spectroscopy ◽  
Low Cost ◽  
Major Axis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Nanorod Arrays ◽  
Au Nanorods ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Oblique Deposition ◽  
Selection Of

ABSTRACTWe have demonstrated surface-enhanced Raman spectroscopy on arrays of Au nanorods aligned in line by a dynamic oblique deposition technique. For the light polarized along the major axis of the nanorods, the plasma resonance of the Au nanorods has been tuned to a wavelength suitable for Raman spectroscopy. The Raman scattering on the discrete nanorods is enhanced significantly compared with that on semi continuous Au films. Since the preparation process is physically bottom-up, it is robust in its selection of the materials and is useful in providing the SERS sensors at low cost.

scholarly journals Refractive index sensing and surface-enhanced Raman spectroscopy using silver–gold layered bimetallic plasmonic crystals

2017 ◽  
Vol 8 ◽  
pp. 2492-2503 ◽  
Author(s):  
Somi Kang ◽  
Sean E Lehman ◽  
Matthew V Schulmerich ◽  
An-Phong Le ◽  
Tae-woo Lee ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Refractive Index ◽  
Electric Fields ◽  
Surface Enhanced Raman Spectroscopy ◽  
Plasmonic Crystals ◽  
Metal Thickness ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Difference Time

Herein we describe the fabrication and characterization of Ag and Au bimetallic plasmonic crystals as a system that exhibits improved capabilities for quantitative, bulk refractive index (RI) sensing and surface-enhanced Raman spectroscopy (SERS) as compared to monometallic plasmonic crystals of similar form. The sensing optics, which are bimetallic plasmonic crystals consisting of sequential nanoscale layers of Ag coated by Au, are chemically stable and useful for quantitative, multispectral, refractive index and spectroscopic chemical sensing. Compared to previously reported homometallic devices, the results presented herein illustrate improvements in performance that stem from the distinctive plasmonic features and strong localized electric fields produced by the Ag and Au layers, which are optimized in terms of metal thickness and geometric features. Finite-difference time-domain (FDTD) simulations theoretically verify the nature of the multimode plasmonic resonances generated by the devices and allow for a better understanding of the enhancements in multispectral refractive index and SERS-based sensing. Taken together, these results demonstrate a robust and potentially useful new platform for chemical/spectroscopic sensing.

Identification and Characterization of Artists' Red Dyes and Their Mixtures by Surface-Enhanced Raman Spectroscopy

2007 ◽  
Vol 61 (9) ◽  
pp. 994-1000 ◽  
Author(s):  
Alyson V. Whitney ◽  
Francesca Casadio ◽  
Richard P. Van Duyne
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Localized Surface Plasmon ◽  
Carminic Acid ◽  
Sers Substrates ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Lac Dye ◽  
Silver Island

Silver film over nanospheres (AgFONs) were successfully employed as surface-enhanced Raman spectroscopy (SERS) substrates to characterize several artists' red dyes including: alizarin, purpurin, carminic acid, cochineal, and lac dye. Spectra were collected on sample volumes (1 × 10−6 M or 15 ng/μL) similar to those that would be found in a museum setting and were found to be higher in resolution and consistency than those collected on silver island films (AgIFs). In fact, to the best of the authors' knowledge, this work presents the highest resolution spectrum of the artists' material cochineal to date. In order to determine an optimized SERS system for dye identification, experiments were conducted in which laser excitation wavelengths were matched with correlating AgFON localized surface plasmon resonance (LSPR) maxima. Enhancements of approximately two orders of magnitude were seen when resonance SERS conditions were met in comparison to non-resonance SERS conditions. Finally, because most samples collected in a museum contain multiple dyestuffs, AgFONs were employed to simultaneously identify individual dyes within several dye mixtures. These results indicate that AgFONs have great potential to be used to identify not only real artwork samples containing a single dye but also samples containing dyes mixtures.

scholarly journals Surface-Enhanced Raman Spectroscopy Characterization of Breast Cell Phenotypes: Effect of Nanoparticle Geometry

2019 ◽  
Vol 2 (11) ◽  
pp. 6960-6970
Author(s):  
Richard E. Darienzo ◽  
Jingming Wang ◽  
Olivia Chen ◽  
Maurinne Sullivan ◽  
Tatsiana Mironava ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Cell Phenotypes

Applications of surface-enhanced Raman spectroscopy in detection fields

Nanomedicine ◽  
2020 ◽  
Vol 15 (30) ◽  
pp. 2971-2989 ◽  
Author(s):  
Ting Lin ◽  
Ya-Li Song ◽  
Juan Liao ◽  
Fang Liu ◽  
Ting-Ting Zeng
Keyword(s):  
Raman Spectroscopy ◽  
Medical Diagnosis ◽  
High Selectivity ◽  
Surface Enhanced Raman Spectroscopy ◽  
Molecular Structures ◽  
Spectroscopy Technique ◽  
Detection Mechanism ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Surface-enhanced Raman spectroscopy (SERS) is a Raman spectroscopy technique that has been widely used in food safety, environmental monitoring, medical diagnosis and treatment and drug monitoring because of its high selectivity, sensitivity, rapidness, simplicity and specificity in identifying molecular structures. This review introduces the detection mechanism of SERS and summarizes the most recent progress concerning the use of SERS for the detection and characterization of molecules, providing references for the later research of SERS in detection fields.

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