scholarly journals Detailed Calorimetric Analysis of Mixed Micelle Formation from Aqueous Binary Surfactants for Design of Nanoscale Drug Carriers

Nanomaterials ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 3288
Author(s):  
Ádám Juhász ◽  
László Seres ◽  
Norbert Varga ◽  
Ditta Ungor ◽  
Marek Wojnicki ◽  
...  
Keyword(s):  
Mixed Micelle ◽  
Mixed Micelles ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Water Soluble ◽  
Titration Calorimetry ◽  
Surfactant Mixtures ◽  
Calorimetric Analysis ◽  
Mixed Micelle Formation ◽  
Ideal Mixing

While numerous papers have been published according to the binary surfactant mixtures, only a few articles provide deeper information on the composition dependence of the micellization, and even less work attempts to apply the enhanced feature of the mixed micelles. The most important parameter of the self-assembled surfactants is the critical micelle concentration (cmc), which quantifies the tendency to associate, and provides the Gibbs energy of micellization. Several techniques are known for determining the cmc, but the isothermal titration calorimetry (ITC) can be used to measure both cmc and enthalpy change (ΔmicH) accompanying micelle formation. Outcomes of our calorimetric investigations were evaluated using a self-developed routine for handling ITC data and the thermodynamic parameters of mixed micelle formation were obtained from the nonlinear modelling of temperature- and composition- dependent enthalpograms. In the investigated temperature and micelle mole fractions interval, we observed some intervals where the cmc is lower than the ideal mixing model predicted value. These equimolar binary surfactant mixtures showed higher solubilization ability for poorly water-soluble model drugs than their individual compounds. Thus, the rapid and fairly accurate calorimetric analysis of mixed micelles can lead to the successful design of a nanoscale drug carrier.

Influence of taurocholate, taurochenodeoxycholate, and taurodehydrocholate on sulfobromophthalein transport into bile.

1979 ◽  
Vol 236 (1) ◽  
pp. E10
Author(s):  
S Binet ◽  
Y Delage ◽  
S Erlinger
Keyword(s):  
Bile Salts ◽  
Mixed Micelle ◽  
Mixed Micelles ◽  
Important Determinant ◽  
Micelle Formation ◽  
Similar Increase ◽  
Mixed Micelle Formation ◽  
Series Of Experiments

To test the hypothesis that incorporation of sulfobromophthalein (BSP) into mixed micelles could account for the increase in its biliary transport maximum (Tmax) by bile salts, we have compared in hamsters the influence on BSP Tmax of taurocholate and taurochenodeoxycholate (two micelle-forming physiological bile salts) to that of taurodehydrocholate, a bile salt which, in vitro, does not form micelles. In a first series of experiments, it was observed that taurocholate and taurochenodeoxycholate increased the secretion of phospholipid (40 and 53%, respectively), and cholesterol (50 and 110%, respectively), whereas taurodehydrocholate decreased the secretion of phospholipid (-31%) and cholesterol (-43%). This result suggests that, in vivo, taurodehydrocholate or its metabolites do not form mixed micelles. In a second series of experiments, it was seen that the three bile salts induced a similar increase in BSP Tmax (63% with taurocholate, 52% with taurochenodeoxycholate, and 51% with taurodehydrocholate). These results provide circumstantial evidence for the hypothesis that mixed micelle formation is not an important determinant of maximal BSP secretion into bile.

scholarly journals Thermodynamic and Interfacial Properties of DTABr/CTABr Mixed Surfactant Systems in Ethanolamine/Water Mixtures: A Conductometry Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Olaseni Segun Esan ◽  
Medinat Olubunmi Osundiya ◽  
Christopher Olumuyiwa Aboluwoye ◽  
Owoyomi Olanrewaju ◽  
Jide Ige
Keyword(s):  
Mixed Micelle ◽  
Mixed Solvent ◽  
Pure Water ◽  
Micelle Formation ◽  
Theoretical Models ◽  
Solvent System ◽  
Synergistic Interaction ◽  
Surfactant Mixtures ◽  
Mixed Micelle Formation ◽  
Free Energy Of Micellization

Mixed-micelle formation in the binary mixtures of dodecyltrimethylammonium bromide (DTABr) and cetyltrimethylammonium bromide (CTABr) surfactants in water-ethanolamine mixed solvent systems has been studied by conductometric method in the temperature range of 298.1 to 313.1 K at 5 K intervals. It was observed that the presence of ethanolamine forced the formation of mixed micelle to lower total surfactant concentration than in water only. The synergistic interaction was quantitatively investigated using the theoretical models of Clint and Rubingh. The interaction parameter β12 was negative at all the mole fractions of DTABr in the surfactant mixtures indicating a strong synergistic interaction, with the presence of ethanolamine in the solvent system resulting in a more enhanced synergism in micelle formation than in water only. The free energy of micellization ΔGM values was more negative in water-ethanolamine mixed solvent system than in pure water indicating more spontaneity in mixed micelle formation in the presence of ethanolamine than in pure water.

scholarly journals Mixed Micelle Formation and Co-adsorption of Anionic/Non-ionic Surfactant Mixtures on Rutile

1996 ◽  
Vol 13 (5) ◽  
pp. 377-395 ◽  
Author(s):  
Ajay K. Vanjara ◽  
Sharad G. Dixit
Keyword(s):  
Mixed Micelle ◽  
Co Adsorption ◽  
Micelle Formation ◽  
Ionic Surfactant ◽  
Surfactant Mixtures ◽  
Mixed Micellization ◽  
Mixed Micelle Formation ◽  
Brij 58 ◽  
Solid Liquid Interface ◽  
Solid Liquid

Mixed micelle formation between the anionic surfactant p-dodecyl benzene sulphonate and the non-ionic surfactants Brij-58, Brij-78 and Brij-99, having the same number of oxyethylene units but a varying number of hydrophobic groups, has been studied using surface tension and NMR spectroscopic measurements. Both hydrophobic–hydrophobic and hydrophilic–hydrophilic interactions play an important role in mixed micelle formation leading to greater non-ideality. The effect of mixed micelle interactions on the adsorption of these surfactants from their mixtures on rutile have been investigated using adsorption and zeta potential measurements. Adsorption above the CMC level is dictated by the relatively higher tendency of mixed micellization over mixed aggregation at the solid/liquid interface.

Determination of Surfactants Based on Mixed-Micelle Formation

1995 ◽  
Vol 67 (11) ◽  
pp. 1872-1880 ◽  
Author(s):  
Dolores. Sicilia ◽  
Soledad. Rubio ◽  
Dolores. Perez-Bendito
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Mixed Micelle Formation

scholarly journals Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Shuaijiang Jin ◽  
Roberto J. Brea ◽  
Andrew K. Rudd ◽  
Stuart P. Moon ◽  
Matthew R. Pratt ◽  
...  
Keyword(s):  
Mixed Micelle ◽  
Micelle Formation ◽  
Native Chemical Ligation ◽  
Chemical Ligation ◽  
Mixed Micelle Formation

scholarly journals Molecular Interactions in Binary Surfactant Solutions: Effect of pH

2019 ◽  
Vol 64 (4) ◽  
pp. 437-445
Author(s):  
Olga Kochkodan ◽  
Victor Maksin ◽  
Nadiya Antraptseva ◽  
Tetyana Semenenko
Keyword(s):  
Molecular Interactions ◽  
Mixed Micelles ◽  
Ph Value ◽  
Chemical Properties ◽  
Micelle Formation ◽  
Bulk Solution ◽  
Surfactant Mixtures ◽  
Solution Ph ◽  
Solution Interface ◽  
Adsorption Layers

By using surface tension and conductivity measurements, the colloid-chemical properties of the mixtures of cationic hexadecylpyridinium bromide with nonionic Triton X-100 surfactants were investigated both in the bulk solution and at air/solution interface at different pH values. The composition of mixed micelles and adsorption layers, parameters of molecular interactions in mixed micelles βm and adsorption layers βσ, as well as standard free energies of micelle formation ΔG0mic and adsorption ΔG0ads were calculated. It was found that molecules of the nonionic surfactant presumably dominate in the mixed micelles and adsorption layers. It was shown that βm and βσ have negative values, which indicate the strengthening of intermolecular interactions in the mixed micelles and adsorption layers. Based on the data obtained, it was suggested that ion-dipole interactions are involved in the formation of intermolecular structures between nonionic and cationic surfactants in aqueous solution and at the air-solution interface. It was shown that βm, βσ as well as ΔG0mic and ΔG0ads parameter depends on the solution pH value. The complex interplay of ion-dipole, protonation and chelation processes, which occur in the surfactant mixtures at different pH and affect the strength of intermolecular interaction, should be taken into account for data analysis.

Sign in / Sign up

Export Citation Format

Share Document