The Relationship between Single Nucleotide Polymorphisms in Taste Receptor Genes, Taste Function and Dietary Intake in Preschool-Aged Children and Adults in the Guelph Family Health Study

Taste is a fundamental determinant of food selection, and inter-individual variations in taste perception may be important risk factors for poor eating habits and obesity. Characterizing differences in taste perception and their influences on dietary intake may lead to an improved understanding of obesity risk and a potential to develop personalized nutrition recommendations. This study explored associations between 93 single nucleotide polymorphisms (SNPs) in sweet, fat, bitter, salt, sour, and umami taste receptors and psychophysical measures of taste. Forty-four families from the Guelph Family Health Study participated, including 60 children and 65 adults. Saliva was collected for genetic analysis and parents completed a three-day food record for their children. Parents underwent a test for suprathreshold sensitivity (ST) and taste preference (PR) for sweet, fat, salt, umami, and sour as well as a phenylthiocarbamide (PTC) taste status test. Children underwent PR tests and a PTC taste status test. Analysis of SNPs and psychophysical measures of taste yielded 23 significant associations in parents and 11 in children. After adjusting for multiple hypothesis testing, the rs713598 in the TAS2R38 bitter taste receptor gene and rs236514 in the KCNJ2 sour taste-associated gene remained significantly associated with PTC ST and sour PR in parents, respectively. In children, rs173135 in KCNJ2 and rs4790522 in the TRPV1 salt taste-associated gene remained significantly associated with sour and salt taste PRs, respectively. A multiple trait analysis of PR and nutrient composition of diet in the children revealed that rs9701796 in the TAS1R2 sweet taste receptor gene was associated with both sweet PR and percent energy from added sugar in the diet. These findings provide evidence that for bitter, sour, salt, and sweet taste, certain genetic variants are associated with taste function and may be implicated in eating patterns. (Support was provided by the Ontario Ministry of Agriculture, Food, and Rural Affairs).

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Single Nucleotide Polymorphisms in Taste Receptor Genes Are Associated with Snacking Patterns of Preschool-Aged Children in the Guelph Family Health Study: A Pilot Study

Nutrients ◽

10.3390/nu10020153 ◽

2018 ◽

Vol 10 (2) ◽

pp. 153 ◽

Cited By ~ 4

Author(s):

Elie Chamoun ◽

Joy Hutchinson ◽

Owen Krystia ◽

Julia Mirotta ◽

David Mutch ◽

...

Keyword(s):

Pilot Study ◽

Single Nucleotide Polymorphisms ◽

Taste Receptor ◽

Family Health ◽

Health Study ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Preschool Aged Children

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Genetic Variation in Taste Receptor Genes (SCNN1B, TRPV1) and Its Correlation with the Perception of Saltiness in Normotensive and Hypertensive Adults

International Journal of Hypertension ◽

10.1155/2021/5559831 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Pradtana Tapanee ◽

Diane K. Tidwell ◽

M. Wes Schilling ◽

Daniel G. Peterson ◽

Terezie Tolar-Peterson

Keyword(s):

Taste Receptor ◽

Recognition Threshold ◽

Taste Perception ◽

Taste Sensitivity ◽

Nucleotide Polymorphisms ◽

Cross Sectional ◽

Single Nucleotide ◽

Salt Taste ◽

Hypertensive Group ◽

Age Range

Background. Different taste preferences correlated with genetic variations may lead to food consumption patterns that contribute to nutrient-related health outcomes such as hypertension. Objectives. The aim of this study was to determine whether single nucleotide polymorphisms (SNPs) in the salt taste receptor genes SCNN1B and TRPV1 affect salt taste perception among normotensive and hypertensive people. Materials and Methods. We conducted a cross-sectional case control study by design consisting of a normotensive and hypertensive group. Participants were 253 adults with age range of 20–82 residing in Mississippi, USA. For each of 128 normotensives and 125 hypertensives, the salt taste recognition threshold and salt taste receptor genotype were determined. Results. The hypertensive group had a higher salt taste recognition threshold than the normotensive group ( P < 0.001 ). The polymorphism of TRPV1, rs4790522, with the AA genotype was associated with a higher salt recognition threshold (lower salt taste sensitivity) in people with hypertension and obesity. Moreover, the polymorphism of TRPV1, rs8065080, and SCNN1B, rs239345, genes were associated with a risk of hypertension ( P = 0.016 and P = 0.024 ). Conclusion. Correlations between SNPs, salt taste sensitivity, and hypertension risk were observed. People with hypertension had a higher salt taste threshold than those with normotension.

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Single nucleotide polymorphisms in the progesterone receptor gene and association with uterine leiomyoma tumor characteristics and disease risk

American Journal of Obstetrics and Gynecology ◽

10.1016/j.ajog.2008.06.015 ◽

2008 ◽

Vol 199 (6) ◽

pp. 648.e1-648.e9 ◽

Cited By ~ 9

Author(s):

Stefan P. Renner ◽

Reiner Strick ◽

Peter A. Fasching ◽

Sonja Oeser ◽

Peter Oppelt ◽

...

Keyword(s):

Single Nucleotide Polymorphisms ◽

Progesterone Receptor ◽

Uterine Leiomyoma ◽

Disease Risk ◽

Receptor Gene ◽

Tumor Characteristics ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Progesterone Receptor Gene

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Single Nucleotide Polymorphisms Identification and Genotyping Analysis of Melanocortin 1 Receptor Gene in Various Plumage Colours Magelang Ducks

International Journal of Poultry Science ◽

10.3923/ijps.2015.207.212 ◽

2015 ◽

Vol 14 (4) ◽

pp. 207-212 ◽

Cited By ~ 5

Author(s):

Ayu Rahayu ◽

Dattadewi Purwantini ◽

Dyah Maharani ◽

Tety Hartatik

Keyword(s):

Single Nucleotide Polymorphisms ◽

Receptor Gene ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Melanocortin 1 Receptor

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Histamine H3 receptor gene variants associated with drug abuse in patients with cocaine use disorder

Journal of Psychopharmacology ◽

10.1177/0269881120961253 ◽

2020 ◽

Vol 34 (11) ◽

pp. 1326-1330

Author(s):

Iñigo Pallardo-Fernández ◽

José Ramón Muñoz-Rodríguez ◽

Carmen González-Martín ◽

Luis F Alguacil

Keyword(s):

Drug Abuse ◽

Single Nucleotide Polymorphisms ◽

Receptor Gene ◽

Gene Variants ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Histamine H3 Receptor ◽

Cocaine Use ◽

H3 Receptor ◽

Histamine H3

Background: Preclinical work revealed significant interactions between ligands of the histamine H3 receptor and different drugs of abuse. In the case of psychostimulants, the results reported are somewhat controversial and human data are still scarce, despite the fact that an inverse agonist of the H3 receptor (pitolisant) has reached the market after approval for the treatment of narcolepsy. Aims: We have studied associations between histamine H3 receptor gene variants and cocaine use disorder to increase the knowledge of the possible involvement of histamine H3 receptor in drug abuse. Methods: Seven single nucleotide polymorphisms of the histamine H3 receptor gene were genotyped by using a multiplexing assay in 248 samples of subjects with cocaine use disorder and 500 randomized samples of subjects representative of the Spanish population. Results: The study of the epidemiological information associated to the samples revealed that subjects with cocaine use disorder broadly abused alcohol, tobacco and cannabinoids. Two single nucleotide polymorphisms (rs3787430 and rs74627870) were found significantly associated with the occurrence of addiction and one more (rs13042865) was specifically related to the severity of cocaine dependence within drug abusers. Conclusions: The associations found in this study further extend the hypothesis that histamine H3 receptor function could be relevant in drug abuse in general and cocaine addiction in particular.

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New Insights on the Evolution of the Sweet Taste Receptor of Primates Adapted to Harsh Environments

Animals ◽

10.3390/ani10122359 ◽

2020 ◽

Vol 10 (12) ◽

pp. 2359

Author(s):

Nur Aida Md Tamrin ◽

Ramlah Zainudin ◽

Yuzine Esa ◽

Halimah Alias ◽

Mohd Noor Mat Isa ◽

...

Keyword(s):

Phylogenetic Trees ◽

Environmental Changes ◽

Receptor Gene ◽

Taste Receptor ◽

Sensory Information ◽

Sweet Taste ◽

Taste Perception ◽

Sweet Taste Receptor ◽

Dietary Preferences ◽

Starting Point

Taste perception is an essential function that provides valuable dietary and sensory information, which is crucial for the survival of animals. Studies into the evolution of the sweet taste receptor gene (TAS1R2) are scarce, especially for Bornean endemic primates such as Nasalis larvatus (proboscis monkey), Pongo pygmaeus (Bornean orangutan), and Hylobates muelleri (Muller’s Bornean gibbon). Primates are the perfect taxa to study as they are diverse dietary feeders, comprising specialist folivores, frugivores, gummivores, herbivores, and omnivores. We constructed phylogenetic trees of the TAS1R2 gene for 20 species of anthropoid primates using four different methods (neighbor-joining, maximum parsimony, maximum-likelihood, and Bayesian) and also established the time divergence of the phylogeny. The phylogeny successfully separated the primates into their taxonomic groups as well as by their dietary preferences. Of note, the reviewed time of divergence estimation for the primate speciation pattern in this study was more recent than the previously published estimates. It is believed that this difference may be due to environmental changes, such as food scarcity and climate change, during the late Miocene epoch, which forced primates to change their dietary preferences. These findings provide a starting point for further investigation.

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