scholarly journals Microbial and Nutritional Programming—The Importance of the Microbiome and Early Exposure to Potential Food Allergens in the Development of Allergies

Nutrients ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1541 ◽  
Author(s):  
Bożena Cukrowska
Keyword(s):  
Gut Microbiota ◽  
Immune Tolerance ◽  
Developed Countries ◽  
Prenatal Period ◽  
Early Exposure ◽  
Food Allergens ◽  
Nutritional Programming ◽  
Number Of Factors ◽  
Potential Food ◽  
Prevention Of Allergy

The “microbiota hypothesis” ties the increase in allergy rates observed in highly developed countries over the last decades to disturbances in the gut microbiota. Gut microbiota formation depends on a number of factors and occurs over approximately 1000 days of life, including the prenatal period. During this period the microbiota helps establish the functional immune phenotype, including immune tolerance. The development of immune tolerance depends also on early exposure to potential food allergens, a process referred to as nutritional programming. This article elaborates on the concepts of microbial and nutritional programming and their role in the primary prevention of allergy.

All Three Subunits of Soybean β-Conglycinin Are Potential Food Allergens

2009 ◽  
Vol 57 (3) ◽  
pp. 938-943 ◽  
Author(s):  
Hari B. Krishnan ◽  
Won-Seok Kim ◽  
Sungchan Jang ◽  
Monty S. Kerley
Keyword(s):  
Food Allergens ◽  
Potential Food

scholarly journals Are Dietary Lectins Relevant Allergens in Plant Food Allergy?

Foods ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1724
Author(s):  
Annick Barre ◽  
Els J.M. Van Damme ◽  
Mathias Simplicien ◽  
Hervé Benoist ◽  
Pierre Rougé
Keyword(s):  
Plant Species ◽  
Fruits And Vegetables ◽  
Rubber Tree ◽  
Type Ii ◽  
Food Allergens ◽  
Edible Plant ◽  
Ribosome Inactivating Proteins ◽  
Pathogenesis Related Protein ◽  
Legume Lectins ◽  
Potential Food

Lectins or carbohydrate-binding proteins are widely distributed in seeds and vegetative parts of edible plant species. A few lectins from different fruits and vegetables have been identified as potential food allergens, including wheat agglutinin, hevein (Hev b 6.02) from the rubber tree and chitinases containing a hevein domain from different fruits and vegetables. However, other well-known lectins from legumes have been demonstrated to behave as potential food allergens taking into account their ability to specifically bind IgE from allergic patients, trigger the degranulation of sensitized basophils, and to elicit interleukin secretion in sensitized people. These allergens include members from the different families of higher plant lectins, including legume lectins, type II ribosome-inactivating proteins (RIP-II), wheat germ agglutinin (WGA), jacalin-related lectins, GNA (Galanthus nivalis agglutinin)-like lectins, and Nictaba-related lectins. Most of these potentially active lectin allergens belong to the group of seed storage proteins (legume lectins), pathogenesis-related protein family PR-3 comprising hevein and class I, II, IV, V, VI, and VII chitinases containing a hevein domain, and type II ribosome-inactivating proteins containing a ricin B-chain domain (RIP-II). In the present review, we present an exhaustive survey of both the structural organization and structural features responsible for the allergenic potency of lectins, with special reference to lectins from dietary plant species/tissues consumed in Western countries.

scholarly journals Impact of Early Exposure to Cefuroxime on the Composition of the Gut Microbiota in Infants Following Cesarean Delivery

2019 ◽  
Vol 210 ◽  
pp. 99-105.e2 ◽  
Author(s):  
Shamrulazhar S. Kamal ◽  
Nana Hyldig ◽  
Łukasz Krych ◽  
Gorm Greisen ◽  
Karen A. Krogfelt ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cesarean Delivery ◽  
Early Exposure

scholarly journals Dendritic Cell Expression of the Signaling Molecule TRAF6 Is Critical for Gut Microbiota-Dependent Immune Tolerance

Immunity ◽  
2013 ◽  
Vol 38 (6) ◽  
pp. 1211-1222 ◽  
Author(s):  
Daehee Han ◽  
Matthew C. Walsh ◽  
Pedro J. Cejas ◽  
Nicholas N. Dang ◽  
Youngmi F. Kim ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Gut Microbiota ◽  
Immune Tolerance ◽  
Signaling Molecule ◽  
Cell Expression

Early exposure to agricultural soil accelerates the maturation of the early-life pig gut microbiota

Anaerobe ◽  
2017 ◽  
Vol 45 ◽  
pp. 31-39 ◽  
Author(s):  
Nguyen Vo ◽  
Tsung Cheng Tsai ◽  
Charles Maxwell ◽  
Franck Carbonero
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Agricultural Soil ◽  
Early Exposure

scholarly journals The Food Contaminant Deoxynivalenol Exacerbates the Genotoxicity of Gut Microbiota

mBio ◽  
2017 ◽  
Vol 8 (2) ◽  
Author(s):  
Delphine Payros ◽  
Ulrich Dobrindt ◽  
Patricia Martin ◽  
Thomas Secher ◽  
Ana Paula F. L. Bracarense ◽  
...  
Keyword(s):  
Dna Damage ◽  
Gut Microbiota ◽  
Developed Countries ◽  
Colorectal Cancers ◽  
Staple Food ◽  
Human Beings ◽  
Food Contaminants ◽  
Cereal Products ◽  
E Coli

ABSTRACT An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers. Deoxynivalenol (DON) is the most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. This study investigates the effect of the food contaminant DON on the genotoxicity of the E. coli strains producing colibactin. In vitro, intestinal epithelial cells were coexposed to DON and E. coli producing colibactin. In vivo, newborn rats colonized at birth with E. coli producing colibactin were fed a DON-contaminated diet. Intestinal DNA damage was estimated by the phosphorylation of histone H2AX. DON exacerbates the genotoxicity of the E. coli producing colibactin in a time- and dose-dependent manner in vitro. Although DON had no effect on the composition of the gut microbiota, and especially on the number of E. coli, a significant increase in DNA damage was observed in intestinal epithelial cells of animals colonized by E. coli strains producing colibactin and coexposed to DON compared to animals colonized with E. coli strains unable to produce colibactin or animals exposed only to DON. In conclusion, our data demonstrate that the genotoxicity of E. coli strains producing colibactin, increasingly present in the microbiota of asymptomatic human beings, is modulated by the presence of DON in the diet. This raises questions about the synergism between food contaminants and gut microbiota with regard to intestinal carcinogenesis. IMPORTANCE An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers. Deoxynivalenol (DON) is the most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. Our in vitro and in vivo results demonstrate that the intestinal DNA damage induced by colibactin-producing E. coli strains was exacerbated by the presence of DON in the diet. This raises questions about the synergism between food contaminants and gut microbiota with regard to intestinal carcinogenesis. IMPORTANCE An increasing number of human beings from developed countries are colonized by Escherichia coli strains producing colibactin, a genotoxin suspected to be associated with the development of colorectal cancers. Deoxynivalenol (DON) is the most prevalent mycotoxin that contaminates staple food—especially cereal products—in Europe and North America. Our in vitro and in vivo results demonstrate that the intestinal DNA damage induced by colibactin-producing E. coli strains was exacerbated by the presence of DON in the diet. This raises questions about the synergism between food contaminants and gut microbiota with regard to intestinal carcinogenesis.

Using a Mobile App to Teach Individuals with Intellectual Disabilities to Identify Potential Food Allergens

2013 ◽  
Vol 28 (3) ◽  
pp. 21-32 ◽  
Author(s):  
Don D. McMahon ◽  
David F. Cihak ◽  
Melinda M. Gibbons ◽  
Liz Fussell ◽  
Sarah Mathison
Keyword(s):  
Intellectual Disabilities ◽  
Mobile App ◽  
Food Allergens ◽  
Potential Food ◽  
Individuals With Intellectual Disabilities

scholarly journals Active Work Participation of the Czech Elderly

2018 ◽  
Vol 66 (5) ◽  
pp. 1287-1293 ◽  
Author(s):  
Lea Kubíčková ◽  
Vladimír Hajko ◽  
Martina Rašticová ◽  
Naďa Hazuchová
Keyword(s):  
The Elderly ◽  
Developed Countries ◽  
Health Condition ◽  
Work Participation ◽  
Active Ageing ◽  
Job Market ◽  
Social Contacts ◽  
The Czech Republic ◽  
Number Of Factors ◽  
Policy Objectives

Majority of developed countries exhibit changing transition towards older population structure. This explains why nowadays, the so–called active ageing – a policy focus to help people remain in charge of their own lives as they age and to promote their continuing contribution to the economy and society – is so frequently discussed. In the context of active ageing, active work participation of elderly is one of the prospective policy objectives, along with the identification of the motives of elderly to stay on the job market. Existing literature indicates that a large number of factors influence this decision, including income and living conditions, whether the person lives alone or not, health condition, social contacts, place of residence, but also varied interventions based on local or national government policies. Empirical results however remain scarce. This article provides insights into what influences the decision of the elderly to remain on the job market in the Czech Republic.

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