scholarly journals A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones?

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1742 ◽  
Author(s):  
Cherubino Di Lorenzo ◽  
Alessandro Pinto ◽  
Roberta Ienca ◽  
Gianluca Coppola ◽  
Giulio Sirianni ◽  
...  

Here we aimed at determining the therapeutic effect of a very low-calorie diet in overweight episodic migraine patients during a weight-loss intervention in which subjects alternated randomly between a very low-calorie ketogenic diet (VLCKD) and a very low-calorie non-ketogenic diet (VLCnKD) each for one month. In a nutritional program, 35 overweight obese migraine sufferers were allocated blindly to 1-month successive VLCKD or VLCnKD in random order (VLCKD-VLCnKD or VLCnKD-VLCD). The primary outcome measure was the reduction of migraine days each month compared to a 1-month pre-diet baseline. Secondary outcome measures were 50% responder rate for migraine days, reduction of monthly migraine attacks, abortive drug intake and body mass index (BMI) change. Only data from the intention-to-treat cohort (n = 35) will be presented. Patients who dropped out (n = 6) were considered as treatment failures. Regarding the primary outcome, during the VLCKD patients experienced −3.73 (95% CI: −5.31, −2.15) migraine days respect to VLCnKD (p < 0.0001). The 50% responder rate for migraine days was 74.28% (26/35 patients) during the VLCKD period, but only 8.57% (3/35 patients) during VLCnKD. Migraine attacks decreased by −3.02 (95% CI: −4.15, −1.88) during VLCKD respect to VLCnKD (p < 0.00001). There were no differences in the change of acute anti-migraine drug consumption (p = 0.112) and BMI (p = 0.354) between the 2 diets. A VLCKD has a preventive effect in overweight episodic migraine patients that appears within 1 month, suggesting that ketogenesis may be a useful therapeutic strategy for migraines.

2018 ◽  
Vol 29 (1) ◽  
pp. 292-296 ◽  
Author(s):  
Alice Albanese ◽  
L. Prevedello ◽  
M. Markovich ◽  
L. Busetto ◽  
R. Vettor ◽  
...  

2017 ◽  
Author(s):  
Preeshila Behary ◽  
George Tharakan ◽  
Werd Al-Najim ◽  
Adrian Brown ◽  
Alexander Miras ◽  
...  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 299-LB
Author(s):  
RAYMOND G. LAU ◽  
SUNIL KUMAR ◽  
JENNY LEE ◽  
CHRIS HALL ◽  
THOMAS PALAIA ◽  
...  

2014 ◽  
Vol 46 ◽  
pp. 627
Author(s):  
ODIN VITE ◽  
VERONICA SANCHEZ ◽  
MIGUEL FRANCISCO HERRERA ◽  
MAUREEN MOSTY

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 155-164 ◽  
Author(s):  
R. R. Henry ◽  
T. A. Wiest-Kent ◽  
L. Scheaffer ◽  
O. G. Kolterman ◽  
J. M. Olefsky

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