Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon. Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups—a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH. Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85). Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT 03782805.

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A prospective randomized controlled trial of the effects of vitamin D supplementation on long-term glycemic control in type 2 diabetes mellitus of Korea

Endocrine Journal ◽

10.1507/endocrj.ej13-0356 ◽

2014 ◽

Vol 61 (2) ◽

pp. 167-176 ◽

Cited By ~ 34

Author(s):

Ohk-Hyun Ryu ◽

Sungwha Lee ◽

Jaemyung Yu ◽

Moon-Gi Choi ◽

Hyung Joon Yoo ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Vitamin D ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Randomized Controlled ◽

Prospective Randomized Controlled Trial

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Vitamin D supplementation for the prevention of type 2 diabetes in overweight adults: study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-015-0851-6 ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 26

Author(s):

Barbora de Courten ◽

Aya Mousa ◽

Negar Naderpoor ◽

Helena Teede ◽

Maximilian P J de Courten ◽

...

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Randomized Controlled Trial ◽

Study Protocol ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Randomized Controlled ◽

Overweight Adults

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Effects of Vitamin D Supplementation on Insulin Sensitivity and Insulin Secretion in Subjects With Type 2 Diabetes and Vitamin D Deficiency: A Randomized Controlled Trial

Diabetes Care ◽

10.2337/dc16-2302 ◽

2017 ◽

Vol 40 (7) ◽

pp. 872-878 ◽

Cited By ~ 34

Author(s):

Hanne L. Gulseth ◽

Cecilie Wium ◽

Kristin Angel ◽

Erik F. Eriksen ◽

Kåre I. Birkeland

Keyword(s):

Type 2 Diabetes ◽

Vitamin D ◽

Randomized Controlled Trial ◽

Insulin Secretion ◽

Insulin Sensitivity ◽

Vitamin D Deficiency ◽

Controlled Trial ◽

Vitamin D Supplementation ◽

Randomized Controlled

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Effect of Vitamin D Supplementation on Some Inflammatory Biomarkers in Type 2 Diabetes Mellitus Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Annals of Nutrition and Metabolism ◽

10.1159/000490358 ◽

2018 ◽

Vol 73 (1) ◽

pp. 62-73 ◽

Cited By ~ 19

Author(s):

Yanting Yu ◽

Liqiang Tian ◽

Yanyu Xiao ◽

Guowei Huang ◽

Meilin Zhang

Keyword(s):

Vitamin D ◽

Randomized Controlled Trials ◽

Meta Analysis ◽

Vitamin D Supplementation ◽

Inflammatory Biomarkers ◽

Controlled Trials ◽

Randomized Controlled ◽

Tnf Α ◽

Hs Crp

Background/Aims: The mechanism, by which vitamin D influences inflammatory biomarkers in type 2 diabetes mellitus (T2DM), is not very well known. Thus, a meta-analysis of randomized controlled trials was conducted to assess the effect of vitamin D supplementation on some inflammatory biomarkers in T2DM subjects. Methods: We searched randomized controlled trials from PubMed and the Cochrane Library in October 2017 and conducted a meta-analysis to evaluate the effectiveness of vitamin D supplementation on high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Either a fixed-effects or a random-effects model was used to calculate pooled effects. Results: We identified 13 studies that met our inclusion criteria. The results indicated that the vitamin D supplementation significant decreased the hs-CRP level by 0.45 μg/mL, whereas the vitamin D supplementation did not influence the TNF-α and IL-6. Subgroup analysis showed that vitamin D significantly lowered hs-CRP by 0.34 μg/mL among trials with a daily vitamin D dose ≤4,000 IU and by 0.31 μg/mL among trials with time of vitamin D supplementation > 12 weeks. Conclusions: Vitamin D supplementation is beneficial for the reduction of hs-CRP inT2DM subjects but does not have a significant influence on TNF-α and IL-6 in T2DM subjects.

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