scholarly journals Beneficial Effects of Vitamin K Status on Glycemic Regulation and Diabetes Mellitus: A Mini-Review

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2485
Author(s):  
Hsin-Jung Ho ◽  
Michio Komai ◽  
Hitoshi Shirakawa

Type 2 diabetes mellitus is a chronic disease that is characterized by hyperglycemia, insulin resistance, and dysfunctional insulin secretion. Glycemic control remains a crucial contributor to the progression of type 2 diabetes mellitus as well as the prevention or delay in the onset of diabetes-related complications. Vitamin K is a fat-soluble vitamin that plays an important role in the regulation of the glycemic status. Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity. This mini-review summarizes the recent insights into the beneficial effects of vitamin K and its possible mechanism of action on insulin sensitivity and glycemic status, thereby suppressing the progression of diabetes mellitus.

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 574
Author(s):  
Anna Obermayer ◽  
Norbert J. Tripolt ◽  
Faisal Aziz ◽  
Christoph Högenauer ◽  
Felix Aberer ◽  
...  

The EndoBarrier™ medical device is a duodenal-jejunal bypass liner designed to mimic the effects of gastric bypass surgery to induce weight loss and glycaemic improvement. In this study, 10 participants with type 2 diabetes mellitus (T2DM), a mean body mass index (BMI) of 43.3 ± 5.0 (kg/m2) and a mean glycated haemoglobin A1c (HbA1c) of 60.6 ± 8.6 mmol/mol were examined at baseline (before implantation of EndoBarrier™), 4 weeks after implantation, at 36 weeks (right before explantation) and 24 weeks after the removal of the device to explore the short and long-term effects on glucose metabolism. Besides a significant reduction in body weight and fat mass, EndoBarrier™ treatment significantly improved insulin sensitivity during Botnia clamp investigations after four weeks of implantation. The beneficial effects decreased over time but remained significant 24 weeks after removal of the device.


2008 ◽  
Vol 25 (3) ◽  
pp. 333-340 ◽  
Author(s):  
N. P. E. Kadoglou ◽  
F. Iliadis ◽  
N. Angelopoulou ◽  
D. Perrea ◽  
C. D. Liapis ◽  
...  

2008 ◽  
Vol 81 (1) ◽  
pp. 42-49 ◽  
Author(s):  
Hae Jin Kim ◽  
Soo Kyung Kim ◽  
Wan Sub Shim ◽  
Jae Hyuk Lee ◽  
Kyu Yeon Hur ◽  
...  

Metabolism ◽  
2008 ◽  
Vol 57 (4) ◽  
pp. 479-487 ◽  
Author(s):  
You-Cheol Hwang ◽  
Eun Young Lee ◽  
Won Jae Lee ◽  
Bong Soo Cha ◽  
Kun-Ho Yoon ◽  
...  

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