scholarly journals Association between Dietary Habits and Fecal Microbiota Composition in Irritable Bowel Syndrome Patients: A Pilot Study

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1479
Author(s):  
Annamaria Altomare ◽  
Federica Del Chierico ◽  
Giulia Rocchi ◽  
Sara Emerenziani ◽  
Chiara Nuglio ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Nutrient Intake ◽  
Dietary Habits ◽  
Fecal Microbiota ◽  
Food Diary ◽  
Linear Discriminant ◽  
Intestinal Dysbiosis ◽  
Microbial Biomarkers ◽  
Irritable Bowel

Intestinal dysbiosis seems to play a role in the pathophysiology of irritable bowel syndrome (IBS). The present pilot study aimed to elucidate the association between nutrient intake and Mediterranean diet (MD) adherence with IBS symptoms and gut microbiota in IBS patients. The nutrient intake of 28 IBS patients and 21 controls was assessed through a food diary, the reference intake ranges (RIs) for energy-yielding macronutrients and the MD serving score (MDSS) index. MD adherence and nutrients intake were compared to IBS symptoms and fecal microbiota, obtained by 16S rRNA targeted-metagenomics. In IBS patients MDSS index was altered compared to controls (p < 0.01). IBS patients with low-MD score reported severe abdominal pain and higher flatulence point-scales. Through Linear discriminant analysis effect size (LEfSe), Erysipelotrichaceae were detected as a microbial biomarker in IBS patients with altered RIs for macronutrients intake, compared to controls. Lactobacillaceae and Lactobacillus were associated to an altered carbohydrates intake in IBS patients, while specific taxonomic biomarkers, such as Aldercreuzia, Mogibacteriaceae, Rikenellaceae, Parabacteroides and F. prausnitzii were associated with an adequate intake of nutrient in these patients. This study supports an association between dietary patterns and gut microbial biomarkers in IBS patients. Further investigations are needed to clarify these connections.

scholarly journals Dietary geraniol ameliorates intestinal dysbiosis and relieves symptoms in irritable bowel syndrome patients: a pilot study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Fernando Rizzello ◽  
Chiara Ricci ◽  
Michela Scandella ◽  
Elena Cavazza ◽  
Elisabetta Giovanardi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Intestinal Dysbiosis ◽  
Irritable Bowel

scholarly journals Diet and gut microbiome interactions of relevance for symptoms in irritable bowel syndrome

Microbiome ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Julien Tap ◽  
Stine Störsrud ◽  
Boris Le Nevé ◽  
Aurélie Cotillard ◽  
Nicolas Pons ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Symptom Severity ◽  
Dietary Habits ◽  
Gastrointestinal Symptoms ◽  
Linear Regression Models ◽  
Food Diary ◽  
New Associations ◽  
Irritable Bowel

Abstract Background While several studies have documented associations between dietary habits and microbiota composition and function in healthy individuals, no study explored these associations in patients with irritable bowel syndrome (IBS), and especially with symptoms. Methods Here, we used a novel approach that combined data from a 4-day food diary, integrated into a food tree, together with gut microbiota (shotgun metagenomic) for individuals with IBS (N = 149) and healthy controls (N = 52). Paired microbiota and food-based trees allowed us to detect new associations between subspecies and diet. Combining co-inertia analysis and linear regression models, exhaled gas levels and symptom severity could be predicted from metagenomic and dietary data. Results We showed that individuals with severe IBS are characterized by a higher intake of poorer-quality food items during their main meals. Our analysis suggested that covariations between gut microbiota at subspecies level and diet could be explained with IBS symptom severity, exhaled gas, glycan metabolism, and meat/plant ratio. We provided evidence that IBS severity is associated with altered gut microbiota hydrogen function in correlation with microbiota enzymes involved in animal carbohydrate metabolism. Conclusions Our study provides an unprecedented resolution of diet-microbiota-symptom interactions and ultimately guides new interventional studies that aim to identify gut microbiome-based nutritional recommendations for the management of gastrointestinal symptoms. Trial registration This trial was registered on the ClinicalTrials.gov, with the registration number NCT01252550, on 3rd December 2010.

T02.02.17 CORRELATION BETWEEN DIETARY HABITS AND FECAL MICROBIOTA COMPOSITION IN IRRITABLE BOWEL SYNDROME PATIENTS

2020 ◽  
Vol 52 ◽  
pp. S91
Author(s):  
A. Altomare ◽  
G. Rocchi ◽  
F. Del Chierico ◽  
S. Emerenziani ◽  
M. Ciccozzi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Dietary Habits ◽  
Fecal Microbiota ◽  
Microbiota Composition ◽  
Irritable Bowel

Tu2025 Fecal Microbiota Transplantation in Irritable Bowel Syndrome With Bloating: Results From a Prospective Pilot Study

2015 ◽  
Vol 148 (4) ◽  
pp. S-963-S-964 ◽  
Author(s):  
Tom Holvoet ◽  
Jerina Boelens ◽  
Marie Joossens ◽  
Jeroen Raes ◽  
Martine De Vos ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Pilot Study ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Prospective Pilot Study ◽  
Irritable Bowel

scholarly journals Gut microbiome, diet and symptom interactions in irritable bowel syndrome

2020 ◽  
Author(s):  
Julien Tap ◽  
Stine Störsrud ◽  
Boris Le Nevé ◽  
Aurélie Cotillard ◽  
Nicolas Pons ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Healthy Subjects ◽  
Dietary Habits ◽  
Hydrogen Metabolism ◽  
Linear Regression Models ◽  
Food Diary ◽  
Novel Approach ◽  
New Association ◽  
Irritable Bowel ◽  
And Function

AbstractWhile several studies have documented associations between dietary habits and microbiota composition and function in healthy subjects, no study explored these associations in patients with irritable bowel syndrome (IBS), and especially in relation to symptoms. Here, we used a novel approach that combined data from 4-day food diary, integrated into a food tree, together with gut microbiota (shotgun metagenomic) for IBS patients (N=149) and healthy subjects (N=52). Paired microbiota and food-based trees allowed to detect new association between subspecies and diet. Combining co-inertia analysis and linear regression models, exhaled gas levels and symptom severity could be predicted from metagenomic and dietary data. IBS patients with severe symptoms had a diet enriched in food items of poorer quality, a high abundance of gut microbial enzymes involved in hydrogen metabolism in correlation with animal carbohydrate (mucin/meat-derived) metabolism. Our study provides unprecedented resolution of diet-microbiota-symptom interactions and ultimately paves the way for personalized nutritional recommendations.

Irritable bowel syndrome and probiotics place in therapeutic strategies

Infectio ro ◽  
2018 ◽  
Vol 56 (4) (1) ◽  
pp. 9-21
Author(s):  
Ștefan-Sorin Aramă
Keyword(s):  
Irritable Bowel Syndrome ◽  
Optimal Strategy ◽  
Vitamin B6 ◽  
Scientific Evidence ◽  
Bifidobacterium Longum ◽  
Lactobacillus Rhamnosus ◽  
Therapeutic Strategies ◽  
Intestinal Dysbiosis ◽  
Irritable Bowel ◽  
The Moment

Irritable bowel syndrome is a frequent digestive condition, with an unclear etiopathogeny. Very probably intestinal dysbiosis plays an important role. For the moment there are no guidelines for treatment. There is scientific evidence for several therapies: modification of diet, non-resorbable antibiotics (rifaximin-α) and probiotics. Giving probiotics after each antibiotic course (an association of Bifidobacterium longum BB536 and Lactobacillus rhamnosus HN001) supplemented with vitamin B6 may be an optimal strategy.

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