scholarly journals Data Recorded in Real Life Support the Safety of Nattokinase in Patients with Vascular Diseases

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2031
Author(s):  
Giuseppe Gallelli ◽  
Giulio Di Mizio ◽  
Caterina Palleria ◽  
Antonio Siniscalchi ◽  
Paolo Rubino ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Vascular Surgery ◽  
Venous Insufficiency ◽  
Life Support ◽  
Real Life ◽  
Vascular Diseases ◽  
Vein Thrombosis ◽  
Protease Enzyme ◽  
Superficial Vein Thrombosis ◽  
Deep Vein

Nattokinase (NK) is a serine protease enzyme with fibrinolytic activity. Even if it could be used for the treatment of several diseases, no data have been published supporting its use patients who underwent vascular surgery. In this study, we evaluated both the efficacy and the safety of nattokinase (100 mg/day per os) in patients admitted to vascular surgery. Patients were of both sexes, >18 years of age, with vascular diseases (i.e., deep vein thrombosis, superficial vein thrombosis, venous insufficiency), and naïve to specific pharmacological treatments (anticoagulants or anti-platelets). Patients were divided into three groups. Group 1: patients with deep vein thrombosis, treated with fondaparinux plus nattokinase. Group 2: patients with phlebitis, treated with enoxaparin plus nattokinase. Group 3: patients with venous insufficiency after classical surgery, treated with nattokinase one day later. During the study, we enrolled 153 patients (age 22–92 years), 92 females (60.1%) and 61 males (39.9%;), and documented that nattokinase was able to improve the clinical symptoms (p < 0.01) without the development of adverse drug reactions or drug interactions. Among the enrolled patients, during follow-up, we did not record new cases of vascular diseases. Attention to patients’ clinical evolution, monitoring of the INR, and timely and frequent adjustment of dosages represent the cornerstones of the safety of care for patients administered fibrinolytic drugs as a single treatment or in pharmacological combination. Therefore, we can conclude that the use of nattokinase represents an efficient and safe treatment able to both prevent and treat patients with vascular diseases.

Objective Diagnosis Of Recurrent Deep Vein Thrombosis

1981 ◽  
Author(s):  
R W Barnes ◽  
D G Turley ◽  
G D Qureshi ◽  
M J Fratkin
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Insufficiency ◽  
Leg Pain ◽  
Venous Obstruction ◽  
Vein Thrombosis ◽  
Postphlebitic Syndrome ◽  
Positive Scan ◽  
Recurrent Deep Vein Thrombosis ◽  
Diagnostic Sensitivity And Specificity ◽  
Deep Vein

Recurrent deep vein thrarbosis must be differentiated from other causes of leg pain, swelling and inflammation, including chronic venous insufficiency or the postphlebitic stasis syndrome. Venous obstruction and/or valvular incompetence was evaluated by Dcppler ultrasound in 229 patients with recurrent leg symptoms following one or more prior episodes of clinical deep vein thrombosis. The diagnostic sensitivity and specificity of the Dcppler technique was 96% and 90%, respectively, in 259 consecutive contrast phlebograms. In a subset of 65 patients with abnormal Dcppler examination, I-125 fibrinogen leg scans were performed prior to institution of anticoagulants in order to establish the diagnosis of recurrent active thrarbosis (positive scan) or inactive postphlebitic disease (negative sca.In the 229 symptomatic patients screened, the Dcppler examination was normal in 87 (38.0%). In 65 patients with abnormal deep veins receiving I-125 fibrinogen, leg scans were positive in 25 (38.5%), suggesting active thrarbosis which was treated by anticoagulants. The remaining 40 patients were treated for the postphlebitic syndrome with leg elevation and elastic support and none developed manife stations of venous thrarboerrbolism.This study suggests that many individuals (38%) with suspected recurrent deep vein thrarbosis have normal leg veins and that the majority (62%) of patients with proven venous abnormalities have inactive (postphlebitic) disease which does not require anti coagulation.

Venous Insufficiency 4 Years after an Episode of Deep Vein Thrombosis: A Clinical and Plethysmographic Investigation

1998 ◽  
Vol 13 (2) ◽  
pp. 53-58
Author(s):  
M. Nordström ◽  
B. Lindblad ◽  
H. Åkesson ◽  
D. Bergqvist ◽  
T. Kjellström
Keyword(s):  
Deep Vein Thrombosis ◽  
Venous Insufficiency ◽  
Outcome Measure ◽  
Clinical Symptoms ◽  
University Hospital ◽  
Vein Thrombosis ◽  
Venous Function ◽  
Deep Vein ◽  
Symptoms And Signs

Objective: To evaluate the frequency of venous insufficiency following deep vein thrombosis (DVT). Design: Follow-up 4 years after a verified DVT. Setting: University hospital in Malmö. Patients: Eighty-seven subjects with venographically verified DVT. Main outcome measure: To compare venous function in legs, with and without previous DVT, by venous straingauge plethysmography and its correlation with clinical symptoms and signs. Results: Fifty-two per cent of patients described general discomfort from the thrombotic leg at follow-up. Active leg ulcers were found in three patients (3%); there were no signs of venous insufficiency in 33% at clinical examination. Thirty-seven patients (75%) with ≥ 1 cm difference in calf circumference between the thrombotic and contralateral leg had suffered a proximal DVT. The refilling time T90 was pathological in 67% and the muscle pump function (RV) in 55%. In the nonthrombotic leg the corresponding figures were 53% and 40%. Nevertheless a positive correlation was found between RV of the thrombotic leg and the contralateral leg ( r = 0.33) but an even stronger correlation was found for T90 ( r = 0.74). Conclusion: Venous insufficiency was found in 60% of legs 4 years after DVT but was also found in 14% of legs without previous thrombosis. This may be caused not only by effects of the thrombosis but also by the ageing process.

scholarly journals Registry of deep vein thrombosis patients hospitalized at the Department of Vascular Diseases, University Hospital Centre Zagreb

2018 ◽  
Vol 13 (11-12) ◽  
pp. 450-451
Author(s):  
Ljiljana Banfić ◽  
Majda Vrkić Kirhmajer ◽  
Mislav Puljević ◽  
Zoran Miovski ◽  
Krešimir Putarek ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Vascular Diseases ◽  
University Hospital ◽  
Vein Thrombosis ◽  
Deep Vein

scholarly journals Special Conditions in Venous Thrombembolism – Case Series

PRILOZI ◽  
2019 ◽  
Vol 40 (2) ◽  
pp. 103-111
Author(s):  
Marijan Bosevski ◽  
Irena Mitevska ◽  
Marica Pavkovic ◽  
Milka Klincheva ◽  
Emilija Trajkovska Lazarova ◽  
...  
Keyword(s):  
Randomized Clinical Trials ◽  
Real Life ◽  
Case Series ◽  
Vascular Diseases ◽  
The Elderly ◽  
Hospital Death ◽  
High Risk Population ◽  
Vein Thrombosis ◽  
Cancer Associated Thrombosis ◽  
Deep Vein

Abstract Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a preventable cause of in-hospital death, and one of the most prevalent vascular diseases. There is a lack of knowledge with regards to contemporary presentation, management, and outcomes of patients with VTE. Many clinically important subgroups (including the elderly, those with recent bleeding, renal insufficiency, disseminated malignancy or pregnant patients) have been under-represented in randomized clinical trials. We still need information from real life data (as example RIETE). The paper presents case series with VTE in special conditions, including cancer associated thrombosis, malignant homeopathies, as well in high risk population.

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