scholarly journals Cord Blood Manganese Concentrations in Relation to Birth Outcomes and Childhood Physical Growth: A Prospective Birth Cohort Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4304
Author(s):  
Yiming Dai ◽  
Jiming Zhang ◽  
Xiaojuan Qi ◽  
Zheng Wang ◽  
Minglan Zheng ◽  
...  
Keyword(s):  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Birth Outcomes ◽  
Umbilical Cord Blood ◽  
Graphite Furnace ◽  
Ponderal Index ◽  
Physical Growth ◽  
Z Score ◽  
Mn Concentrations

Gestational exposure to manganese (Mn), an essential trace element, is associated with fetal and childhood physical growth. However, it is unclear which period of growth is more significantly affected by prenatal Mn exposure. The current study was conducted to assess the associations of umbilical cord-blood Mn levels with birth outcomes and childhood continuous physical development. The umbilical cord-blood Mn concentrations of 1179 mother–infant pairs in the Sheyang mini birth cohort were measured by graphite furnace atomic absorption spectrometry (GFAAS). The association of cord-blood Mn concentrations with birth outcomes, and the BMI z-score at 1, 2, 3, 6, 7 and 8 years old, were estimated separately using generalized linear models. The relationship between prenatal Mn exposure and BMI z-score trajectory was assessed with generalized estimating equation models. The median of cord-blood Mn concentration was 29.25 μg/L. Significantly positive associations were observed between Mn exposure and ponderal index (β, regression coefficient = 0.065, 95% CI, confidence interval: 0.021, 0.109; p = 0.004). Mn exposure was negatively associated with the BMI z-score of children aged 1, 2, and 3 years (β = −0.383 to −0.249, p < 0.05), while no significant relationships were found between Mn exposure and the BMI z-score of children at the age of 6, 7, and 8 years. Prenatal Mn exposure was related to the childhood BMI z-score trajectory (β = −0.218, 95% CI: −0.416, −0.021; p = 0.030). These results indicated that prenatal Mn exposure was positively related to the ponderal index (PI), and negatively related to physical growth in childhood, which seemed most significant at an early stage.

scholarly journals Iron stores at birth in a full-term normal birth weight birth cohort with a low level of inflammation

2020 ◽  
Vol 40 (12) ◽  
Author(s):  
Joy Y. Zhang ◽  
Jing Wang ◽  
Qinsheng Lu ◽  
Meizhen Tan ◽  
Ru Wei ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Serum Ferritin ◽  
Umbilical Cord Blood ◽  
Normal Birth Weight ◽  
Blood Samples ◽  
Iron Stores ◽  
Normal Birth

Abstract Iron stores at birth are essential to meet iron needs during the first 4–6 months of life. The present study aimed to investigate iron stores in normal birth weight, healthy, term neonates. Umbilical cord blood samples were collected from apparently normal singleton vaginal deliveries (n=854). Subjects were screened and excluded if C-reactive protein (CRP) &gt; 5 mg/l or α1-acid glycoprotein (AGP) &gt; 1 g/l, preterm (&lt;37 complete weeks), term &lt; 2500g or term &gt; 4000g. In total, 762 samples were included in the study. Serum ferritin, soluble transferrin receptor (sTfR), hepcidin, and erythropoietin (EPO) were measured in umbilical cord blood samples; total body iron (TBI) (mg/kg) was calculated using sTfR and ferritin concentrations. A total of 19.8% newborns were iron deficient (ferritin 35 μg/l) and an additional 46.6% had insufficient iron stores (ferritin &lt; 76 μg/l). There was a positive association between serum ferritin and sTfR, hepcidin, and EPO. Gestational age was positively associated with ferritin, sTfR, EPO, and hepcidin. In conclusion, we demonstrate a high prevalence of insufficient iron stores in a Chinese birth cohort. The value of cord sTfR and TBI in the assessment of iron status in the newborn is questionable, and reference ranges need to be established.

scholarly journals DHA-rich n-3 PUFAs intake from the early- and mid-pregnancy decreases the weight gain by affecting the DNA methylation status among Chinese Han infants

2021 ◽  
Author(s):  
Ping Li ◽  
Xiaoyu Chen ◽  
Tianyi Teng ◽  
Xiuqin Fan ◽  
Tiantian Tang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Methylation Status ◽  
Z Score ◽  
Chinese Han ◽  
Follow Up Study ◽  
Cpg Sites

Background: Maternal exogenous docosahexaenoic acid (DHA)-rich n-3 polyunsaturated fatty acids (PUFAs) intake during the pregnancy, especially DHA, has inconsistent effects on reducing the fat storage of the infants in different clinical studies. Objectives: We sought to determine the effects of maternal exogenous DHA-rich n-3 PUFAs capsule intake from the different pregnancy periods on the weight gain of their infants through modifying the DNA methylation status of obesity-associated genes in the umbilical cord blood. Design: A prospective 3-year follow-up study after the pregnancy was enrolled in this cohort from May to October 2016. They were divided into different groups according to the initial time of exogenous DHA capsule intake through the questionnaires (S1 – early trimester, S2 – mid-trimester, S3 – late trimester, and control – without). The concentrations and compositions of DHA were determined by gas chromatography. We applied quantitative DNA methylation states of the obesity-associated genes in the umbilical cord blood. The growth outcomes and relevant Z-scores were recorded at birth and 1 and 2 years. The correlations between DNA methylation status of the obesity-associated genes with the consents of DNA and body mass index (BMI) values were investigated as the measures. Results: In total, 205 pregnant women and their infants were eligible for this follow-up study. The concentrations and compositions of DHA in the colostrum and umbilical cord blood were higher in the S1 and S2 groups than those in the control and S3 groups as well as the decreased weight, BMI, weight for age Z-score (WAZ) and BMI for age Z-score (BMI Z) at birth and 1 and/or 2 years, and higher levels of global DNA methylation and many CpG sites in the obesity-associated genes, such as CpG2, CpG9, CpG11, and CpG16 of PPAR-γ; CpG2,3, CpG4-6, CpG8, CpG9,10, CpG11, CpG15,16, and average of CCAAT/enhancer binding protein α (C/EBP-α); CpG1 and average of adiponectin; CpG1, CpG2, CpG3, CpG5, CpG6, CpG7, and average of insulin-like growth factor 2 (IGF-2); CpG6, CpG7, CpG9, CpG16, CpG23, and CpG24 of leptin, which were more obvious in the S1 group when compared with those in the S2 group. These above hypermethylation levels of CpG sites were negatively correlated with the BMI and positively related with the changes of DHA in the colostrum and umbilical cord blood. Conclusions: Maternal exogenous DHA-rich n-3 PUFAs intake from early- and mid- trimesters of the pregnancy may avoid the development of obesity among Chinese Han infants until 2 years by modulating DNA methylation states of obesity-associated genes, which could provide attractive targets for prenatal prevention of the metabolic disorders.

scholarly journals Perfluorinated Compounds in Umbilical Cord Blood and Adverse Birth Outcomes

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42474 ◽  
Author(s):  
Mei-Huei Chen ◽  
Eun-Hee Ha ◽  
Ting-Wen Wen ◽  
Yi-Ning Su ◽  
Guang-Wen Lien ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Birth Outcomes ◽  
Umbilical Cord Blood ◽  
Perfluorinated Compounds ◽  
Adverse Birth Outcomes

scholarly journals Trace of heavy metals in maternal and umbilical cord blood samples in association with birth outcomes in Baghdad, Iraq

2017 ◽  
Vol 156 ◽  
pp. 00003
Author(s):  
Mayyadah Hasan Rhaif Al-Sahlanee ◽  
Ramzun Maizan Ramli ◽  
Miami Abdul Hassan Ali ◽  
Nada Fadhil Tawfiq ◽  
Nurul Zahirah Noor Azman ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Birth Outcomes ◽  
Umbilical Cord Blood ◽  
Blood Samples

The Association Between Perfluoroalkyl Chemical Levels in Umbilical Cord Blood and Birth Outcomes

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S240 ◽  
Author(s):  
Ting-Wen Wen ◽  
Mei-Huei Chen ◽  
Guang-Wen Lien ◽  
Yen-Ju Lin ◽  
Wu-Shiun Hsieh ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Birth Outcomes ◽  
Umbilical Cord Blood

scholarly journals Expression of the filaggrin gene in umbilical cord blood predicts eczema risk in infancy: A birth cohort study

2017 ◽  
Vol 47 (9) ◽  
pp. 1185-1192 ◽  
Author(s):  
A. H. Ziyab ◽  
S. Ewart ◽  
G. A. Lockett ◽  
H. Zhang ◽  
H. Arshad ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cord Blood ◽  
Birth Cohort ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Birth Cohort Study

scholarly journals Prevalence of Malaria and Associated Factors among Delivering Mothers in Northwest Ethiopia

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Asmamaw Limenih ◽  
Woynshet Gelaye ◽  
Getaneh Alemu
Keyword(s):  
Plasmodium Falciparum ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Birth Outcomes ◽  
Umbilical Cord Blood ◽  
Northwest Ethiopia ◽  
Plasmodium Infection ◽  
Blood Samples

Background. Malaria is one of the leading causes of morbidity and mortality especially in pregnant women and under-five-year-old children. However, data on the prevalence among delivering mothers, potential fetal transmission, and associated birth outcomes is lacking in Ethiopia. Objective. To assess the prevalence of Plasmodium infection from peripheral, placental, and cord blood samples among delivering mothers in Kuch health center, Northwest Ethiopia. Methods. An institution-based cross-sectional study was conducted among 218 delivering mothers from February to May 2021 in Kuch health center. Data on sociodemographic characteristics and clinical and obstetric history of mothers were collected using a structured questionnaire. Giemsa stained blood films from maternal capillary and placental and umbilical cord blood were examined for plasmodium infection. Data were analyzed using Statistical Package for the Social Sciences version 23 software package. Results. The prevalence of maternal, placental, and umbilical cord malaria was 6.4% (14/218), 2.3% (5/218), and 0.5% (1/218), respectively. Plasmodium falciparum and Plasmodium vivax accounted 3.7% (8/218) and 2.8% (6/218), respectively, in maternal peripheral blood but only Plasmodium falciparum was detected in placental and umbilical cord blood samples. Maternal malaria had significant association with primigravida ( χ 2 = 12.611 , p = 0.002 ) and low birth weight ( χ 2 = 8.381 , p = 0.004 ). Placental malaria was also significantly associated with low birth weight ( χ 2 = 32.255 , p ≤ 0.001 ). Conclusion. The prevalence of malaria among delivering mothers was considerable. Maternal peripheral malaria had a significant association with gravidity and birth weight. Placental and umbilical cord malaria also had a significant association with birth weight. Pregnant mothers should be examined for malaria and receive appropriate treatment to prevent adverse birth outcomes.

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