scholarly journals Screening for Human T-Cell Lymphotropic Virus (HTLV) in Pregnant Women in the Peruvian Amazon and Systematic Review with Meta-Analysis of HTLV Infection in Peru

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 260
Author(s):  
José-Manuel Ramos-Rincón ◽  
Sonia Ortiz-Martínez ◽  
María-Esteyner Vásquez-Chasnamote ◽  
Eva de-Miguel-Balsa ◽  
Olga-Nohelia Gamboa-Paredes ◽  
...  
Keyword(s):  
Systematic Review ◽  
T Cell ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Spastic Paraparesis ◽  
Infection Prevalence ◽  
Peruvian Amazon ◽  
Childbearing Age ◽  
Htlv Infection ◽  
Human T Cell

Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (2) Methods. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. (3) Results. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs 26.8 [SD 6.3]; p = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for Strongyloides, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of HTLV infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted.

scholarly journals Vitamin D and HTLV Infection: A Systematic Review

2019 ◽  
Vol 11 (1) ◽  
pp. 35-42
Author(s):  
E Netto ◽  
M Gomes-Neto ◽  
C Brites
Keyword(s):  
Systematic Review ◽  
Vitamin D ◽  
T Cell ◽  
Case Reports ◽  
Spastic Paraparesis ◽  
Experimental Studies ◽  
Cochrane Library ◽  
Parathyroid Hormone Related Protein ◽  
Htlv Infection ◽  
Human T Cell

Background:Vitamin D has been associated with the pathogenesis of infectious diseases.Objective:To perform a systematic review on the association of vitamin D and outcomes of HTLV (Human T-cell lymphotropic virus) infection.Methods:We searched PubMed, LILACs, Scielo, Embase and Cochrane Library for studies addressing vitamin D and HTLV infection. We included studies published in English since 1980. Studies associated with HIV, bone metabolism and not related to HTLV- associated myelopathy/ tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia/lymphoma (ATL) were excluded.Results:Twenty-three studies were selected and sixteen studies were included in the review (eight experimental studies, three case reports, three cases series, one cross-sectional study and one review). Fourteen studies were focused on ATL, and two on HAM/TSP. The available data show thatin vitroexposure to 1,25(OH)2D inhibits proliferation of HTLV-infected lymphocytes in patients with ATL or HAM/TSP. It has been observed that hypercalcemia, the main cause of death in patients with ATL, is not associated with serum levels of 1,25(OH)2D or parathyroid hormone-related protein, but leukemia inhibitory factor/D factor seems to be an important factor for hypercalcemia pathogenesis. It was also demonstrated an association between the VDRApaIgene polymorphism and a decreased risk of HAM/TSP in HTLV positive individuals.Conclusion:Despite the small number and heterogeneity of the studies, this systematic review suggests that vitamin D play a role in the pathogenesis of HTLV-associated diseases.

O312 Human T-cell lymphotropic virus (HTLV) infection in Brazilian pregnant women

2009 ◽  
Vol 107 ◽  
pp. S181-S182
Author(s):  
E. Figueiró-Filho ◽  
L. Coelho ◽  
I. Breda ◽  
V. Oliveira ◽  
L. Melo ◽  
...  
Keyword(s):  
T Cell ◽  
Pregnant Women ◽  
Htlv Infection ◽  
Human T Cell

Prevalence of human T-cell lymphotropic virus type-1 infection among blood donors in mainland China: a systematic review and meta-analysis of the last 20 years

2019 ◽  
Vol 12 (8) ◽  
pp. 579-587 ◽  
Author(s):  
Xue Chen ◽  
Fang Liu ◽  
Xuemei Fu ◽  
Yi Feng ◽  
Dingding Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
T Cell ◽  
Virus Type ◽  
Blood Donors ◽  
Meta Analysis ◽  
Mainland China ◽  
Human T Cell

scholarly journals Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

Retrovirology ◽  
2011 ◽  
Vol 8 (S1) ◽  
Author(s):  
Sérgio Arruda ◽  
Camila Loureiro ◽  
Marcos Almeida ◽  
Dayana Mendes ◽  
Maria F R Grassi ◽  
...  
Keyword(s):  
Systematic Review ◽  
T Cell ◽  
Virus Type ◽  
Meta Analysis ◽  
Human T Cell

scholarly journals Iodine deficiency in women of childbearing age in Brazil: systematic review and meta-analysis

Revista Vitae ◽  
2021 ◽  
Vol 28 (2) ◽  
Author(s):  
Rosa Camila Lucchetta ◽  
Ana Luísa Rodriguez Gini ◽  
Sophia de Andrade Cavicchioli ◽  
Marcela Forgerini ◽  
Fabiana Rossi Varallo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Sample Size ◽  
Iodine Deficiency ◽  
Associated Factors ◽  
Meta Analysis ◽  
Public Health Problem ◽  
Small Sample ◽  
Women Of Childbearing Age ◽  
Childbearing Age

Background: Despite current policies of salt iodination, iodine deficiency is still a global public health problem, especially in women. So far, conflicting evidence has been suggested for the prevalence of iodine deficiency in Brazil. Objective: To estimate the prevalence of iodine deficiency and associated factors in women of childbearing age in Brazil. Methods: A systematic review was conducted using databases (PubMed, LILACS, WHO, Scopus, and Capes’ dissertation and thesis), from inception to May 2020. Meta-analyses of proportions were performed using the variance inverse for the fixed model. Reporting and methodological quality were assessed using the Joanna Briggs Institute tool to prevalence studies. Results: Our review identified seven studies published between 2002 e 2017, including 1354 participants, especially pregnant women. All studies presented at least one quality limitation, mainly regarding the sampling method (i.e., convenience) and small sample size. The prevalence of iodine deficiency ranged among studies from 16% to 62%. In contrast, the meta-analysis identified a mean prevalence of 40% (95% confidence interval, CI 37%-43%) for pregnant women and 13% (95% CI 4%-24%) for non-pregnant women. Cumulative meta-analysis suggests a tendency of higher iodine deficiency prevalence from 2018 in pregnant women. Conclusions: Although this systematic review identified studies with poor methodological and reporting quality, a high prevalence of iodine deficiency was identified in pregnant women, reinforcing the importance of national nutritional policies for monitoring iodine status in this population. Future studies should consider random probabilistic sampling, appropriate sample size, and pre-defined subgroup analysis to adequately inform the prevalence of iodine deficiency and associated factors in women of childbearing age and support health policies.

scholarly journals Seroprevalence of human T-cell lymphotropic virus type I among pregnant women in Accra, Ghana

2006 ◽  
Vol 55 (6) ◽  
pp. 765-770 ◽  
Author(s):  
Henry B. Armah ◽  
Edwin G. Narter-Olaga ◽  
Andrew A. Adjei ◽  
Kofi Asomaning ◽  
Richard K. Gyasi ◽  
...  
Keyword(s):  
T Cell ◽  
Pregnant Women ◽  
Virus Type ◽  
Antenatal Clinic ◽  
Military Hospital ◽  
Type I ◽  
Childbearing Age ◽  
Human T Cell ◽  
Immunodeficiency Virus ◽  
Ghanaian Women

Infection with human T-cell lymphotropic virus type I (HTLV-I) occurs mainly in Japan, Central and West Africa and the Caribbean Basin. Although antibody to HTLV-I has been reported among pregnant women in several endemic countries, there is no information regarding the seroprevalence in pregnant Ghanaian women. The reported seroprevalence of HTLV-I among healthy Ghanaian blood donors is between 0.5 and 4.2 %. Therefore, this study was conducted to determine the seroprevalence of HTLV-I among pregnant women attending the antenatal clinic at the 37 Military Hospital, Accra, Ghana, between the months of January and December 2003. The presence of antibodies specific for HTLV-I/II was tested using a particle agglutination test (PAT) kit and confirmed by Western blotting (WB). Of the 960 sera tested, HTLV-I/II antibodies were detected in 24 samples using the PAT kit. WB results indicated that, of the 24 positive PAT specimens, 20 specimens (83.3 %) were HTLV-I positive, one (4.2 %) was HTLV-II positive, two (8.3 %) were HTLV positive and one (4.2 %) was indeterminate. Therefore, the overall seroprevalence of HTLV-I was 2.1 %. Seroprevalence increased with age, suggesting sexual contact as the primary mode of transmission among women of childbearing age, rather than breastfeeding during infancy. The seroprevalence of 2.1 % reported here for HTLV-I in pregnant women in Accra is comparable to that of human immunodeficiency virus among the same population. In conclusion, the results indicate that HTLV-I is prevalent among asymptomatic Ghanaian pregnant women and thus there is a need to consider introducing antenatal screening for HTLV-I in Ghana.

Identifying psychosocial determinants related to alcohol consumption during pregnancy: a systematic literature review

2018 ◽  
Author(s):  
Sylvia Roozen ◽  
Gjalt - Jorn Ygram Peters ◽  
Gerjo Kok ◽  
Leopold Curfs
Keyword(s):  
Alcohol Consumption ◽  
Pregnant Women ◽  
Perceived Risk ◽  
Human Subjects ◽  
Meta Analysis ◽  
Univariate Analysis ◽  
Childbearing Age ◽  
Psychosocial Determinants ◽  
Maternal Alcohol ◽  
Maternal Alcohol Consumption

BackgroundFetal Alcohol Spectrum Disorders (FASD) is an important global health problem in need of prevention. For FASD prevention it is important to understand why pregnant women engage or do not engage in drinking alcohol. It remains unknown which psychosocial determinants related to maternal alcohol consumption are most in need of prevention. The objective of this study was to identify these.MethodWe searched in PubMed, PsychINFO, PsychARTICLES, ERIC, CINAHL, EMBASE and MEDLINE databases up to May 2018 using an extensive query consisting of keywords related to pregnancy (e.g., maternal, prenatal), alcohol use (e.g., alcohol, drink) and determinants (e.g., attitude, norm). Studies were excluded when not published in English, were reviews, or involved non-human subjects. Substantial heterogeneity precluded aggregation or meta-analysis of the data. Instead, data were qualitatively inspected.ResultsA total of 23 studies including 150 identified items were eligible for data analysis. Studies covered over 15 psychosocial determinants (e.g., attitude, perceived social norm, risk perception). Studies differed in their operationalizations. As a majority of data was based on univariate analysis, little is known about the relationship with specific drinking behaviors. The majority of studies targeted perceived risk and motivation to comply with each social referents' approval or disapproval. A large proportion of studies focused on disadvantages and risks of maternal alcohol consumption. Results from these studies show that women do not continue to drink because the risks are unknown to them. Cautious interpretation is needed while the observed heterogeneity hindered firm conclusions. Conclusion We aimed to identify all relevant psychosocial determinants of maternal alcohol consumption behavior(s). The state of the literature precludes such conclusions. It remains unknown which determinants are most in need of intervention. It is recommended for future studies to (i) identify all possible psychosocial determinants of drinking during pregnancy using both quantitative and qualitative methods; (ii) include different target groups (e.g., women with unplanned pregnancies, pregnant women, women in childbearing age); (iii) identify key environmental agents; (iv) operationalize their measures based on theoretical models; (v) report specific variables such as the study method and association with behavior.

Comparison of Perinatal Outcomes of Pregnant Women with SARS, MERS and COVID-19: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Pengming Sun ◽  
Hangjing Gao ◽  
Xiqi Huang ◽  
Huanrui Zheng ◽  
Hongning Cai ◽  
...  
Keyword(s):  
Systematic Review ◽  
Pregnant Women ◽  
Meta Analysis ◽  
Perinatal Outcomes
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