In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms

More than 50 years ago, the first concepts for gastroretentive drug delivery systems were developed. Despite extensive research in this field, there is no single formulation concept for which reliable gastroretention has been demonstrated under different prandial conditions. Thus, gastroretention remains the holy grail of oral drug delivery. One of the major reasons for the various setbacks in this field is the lack of predictive in vitro and in vivo test methods used during preclinical development. In most cases, human gastrointestinal physiology is not properly considered, which leads to the application of inappropriate in vitro and animal models. Moreover, conditions in the stomach are often not fully understood. Important aspects such as the kinetics of fluid volumes, gastric pH or mechanical stresses have to be considered in a realistic manner, otherwise, the gastroretentive potential as well as drug release of novel formulations cannot be assessed correctly in preclinical studies. This review, therefore, highlights the most important aspects of human gastrointestinal physiology and discusses their potential implications for the evaluation of gastroretentive drug delivery systems.

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FLOATING DRUG DELIVERY SYSTEM: A REVIEW

International Journal of Indigenous Herbs and Drugs ◽

10.46956/ijihd.vi.112 ◽

2021 ◽

pp. 33-39

Author(s):

Archana Tomar ◽

Arpita Singh ◽

Amresh Gupta ◽

Satyawan Singh

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Pharmaceutical Dosage Form ◽

Floating Drug Delivery ◽

Floating Drug Delivery System

The main motto of working on that article on floating drug delivery systems (FDDS) is to make a compiled report on the recent studies and research with special consideration on the principle mechanism of flotation to achieve gastric retention. The scientiﬁc and technological advancements were made in the last few years in the research and development of rate-controlled oral drug delivery systems by overcoming physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). This review also epitomized the in-vitro procedure, in-vivo to assess the pursuance and implementation of floating systems, and applications of these systems. These methods are useful to various queries experienced during the development of a pharmaceutical dosage form.

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Self-Nano-Emulsifying Drug-Delivery Systems: From the Development to the Current Applications and Challenges in Oral Drug Delivery

Pharmaceutics ◽

10.3390/pharmaceutics12121194 ◽

2020 ◽

Vol 12 (12) ◽

pp. 1194

Author(s):

Aristote B. Buya ◽

Ana Beloqui ◽

Patrick B. Memvanga ◽

Véronique Préat

Keyword(s):

Drug Delivery ◽

Patient Compliance ◽

Oral Delivery ◽

Drug Delivery Systems ◽

Water Solubility ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

Statistical Design Of Experiments

Approximately one third of newly discovered drug molecules show insufficient water solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems (SNEDDSs) are one of the emerging strategies developed to tackle the issues associated with their oral delivery. SNEDDSs are composed of an oil phase, surfactant, and cosurfactant or cosolvent. SNEDDSs characteristics, their ability to dissolve a drug, and in vivo considerations are determinant factors in the choice of SNEDDSs excipients. A SNEDDS formulation can be optimized through phase diagram approach or statistical design of experiments. The characterization of SNEDDSs includes multiple orthogonal methods required to fully control SNEDDS manufacture, stability, and biological fate. Encapsulating a drug in SNEDDSs can lead to increased solubilization, stability in the gastro-intestinal tract, and absorption, resulting in enhanced bio-availability. The transformation of liquid SNEDDSs into solid dosage forms has been shown to increase the stability and patient compliance. Supersaturated, mucus-permeating, and targeted SNEDDSs can be developed to increase efficacy and patient compliance. Self-emulsification approach has been successful in oral drug delivery. The present review gives an insight of SNEDDSs for the oral administration of both lipophilic and hydrophilic compounds from the experimental bench to marketed products.

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Unique catanionic vesicles as a potential “Nano-Taxi” for drug delivery systems. In vitro and in vivo biocompatibility evaluation

RSC Advances ◽

10.1039/c6ra27020d ◽

2017 ◽

Vol 7 (9) ◽

pp. 5372-5380 ◽

Cited By ~ 7

Author(s):

Soledad Stagnoli ◽

M. Alejandra Luna ◽

Cristian C. Villa ◽

Fabrisio Alustiza ◽

Ana Niebylski ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Oral Drug ◽

Catanionic Surfactant ◽

Catanionic Vesicles ◽

System P ◽

Oral Drug Delivery System

We evaluatein vitroandin vivotoxicity and stability in an acidic environment of new vesicles formed by the catanionic surfactant AOT-BHD in order to investigate their potential application as an oral drug delivery system.

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In Vitro Release Behavior of Naproxen in Alginate–Chitosan Microparticles as Oral Drug Delivery Systems

Scientia Pharmaceutica ◽

10.3797/scipharm.cespt.8.pdd12 ◽

2010 ◽

Vol 78 (3) ◽

pp. 601-601

Author(s):

ČALIJA

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

In Vitro Release ◽

Delivery Systems ◽

Oral Drug ◽

Release Behavior ◽

Vitro Release ◽

Oral Drug Delivery Systems

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In vivo evaluation of guargum-based colon-targeted oral drug delivery systems of celecoxib in human volunteers

European Journal of Drug Metabolism and Pharmacokinetics ◽

10.1007/bf03192338 ◽

2002 ◽

Vol 27 (4) ◽

pp. 273-280 ◽

Cited By ~ 10

Author(s):

Y. S. R. Krishnaiah ◽

V. Satyanarayana ◽

B. Dinesh Kumar ◽

R. S. Karthikeyan ◽

P. Bhaskar

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Delivery Systems ◽

Oral Drug ◽

In Vivo Evaluation ◽

Human Volunteers ◽

Oral Drug Delivery Systems

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Emerging Applications of Drug Delivery Systems in Oral Infectious Diseases Prevention and Treatment

Molecules ◽

10.3390/molecules25030516 ◽

2020 ◽

Vol 25 (3) ◽

pp. 516 ◽

Cited By ~ 8

Author(s):

Jingou Liang ◽

Xinyu Peng ◽

Xuedong Zhou ◽

Jing Zou ◽

Lei Cheng

Keyword(s):

Drug Delivery ◽

Infectious Diseases ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Oral Candidiasis ◽

Delivery Systems ◽

Oral Drug ◽

Oral Microbiota ◽

Stimuli Responsive

The oral cavity is a unique complex ecosystem colonized with huge numbers of microorganism species. Oral cavities are closely associated with oral health and sequentially with systemic health. Many factors might cause the shift of composition of oral microbiota, thus leading to the dysbiosis of oral micro-environment and oral infectious diseases. Local therapies and dental hygiene procedures are the main kinds of treatment. Currently, oral drug delivery systems (DDS) have drawn great attention, and are considered as important adjuvant therapy for oral infectious diseases. DDS are devices that could transport and release the therapeutic drugs or bioactive agents to a certain site and a certain rate in vivo. They could significantly increase the therapeutic effect and reduce the side effect compared with traditional medicine. In the review, emerging recent applications of DDS in the treatment for oral infectious diseases have been summarized, including dental caries, periodontitis, peri-implantitis and oral candidiasis. Furthermore, oral stimuli-responsive DDS, also known as “smart” DDS, have been reported recently, which could react to oral environment and provide more accurate drug delivery or release. In this article, oral smart DDS have also been reviewed. The limits have been discussed, and the research potential demonstrates good prospects.

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Supersaturated Silica-Lipid Hybrid Oral Drug Delivery Systems: Balancing Drug Loading and In Vivo Performance

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.118.254466 ◽

2018 ◽

Vol 370 (3) ◽

pp. 742-750 ◽

Cited By ~ 5

Author(s):

Hayley B. Schultz ◽

Miia Kovalainen ◽

Karl F. Peressin ◽

Nicky Thomas ◽

Clive A. Prestidge

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Oral Drug Delivery ◽

Drug Loading ◽

Delivery Systems ◽

Oral Drug ◽

Oral Drug Delivery Systems

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NANO/MICROSCALE TECHNOLOGIES FOR DRUG DELIVERY

Journal of Mechanics in Medicine and Biology ◽

10.1142/s021951941100406x ◽

2011 ◽

Vol 11 (02) ◽

pp. 337-367 ◽

Cited By ~ 7

Author(s):

HAIRUI LI ◽

JASPREET SINGH KOCHHAR ◽

JING PAN ◽

SUI YUNG CHAN ◽

LIFENG KANG

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Drug Testing ◽

New Technologies ◽

Delivery Systems ◽

In Vitro Tests ◽

In Vivo Test ◽

Micro Particles

Nano- and microscale technologies have made a marked impact on the development of drug delivery systems. The loading efficiency and particle size of nano/micro particles can be better controlled with these new technologies than conventional methods. Moreover, drug delivery systems are moving from simple particles to smart particles and devices with programmable functions. These technologies are also contributing to in vitro and in vivo drug testing, which are important to evaluate drug delivery systems. For in vitro tests, lab-on-a-chip models are potentially useful as alternatives to animal models. For in vivo test, nano/micro-biosensors are developed for testing chemicals and biologics with high sensitivity and selectivity. Here, we review the recent development of nanoscale and microscale technologies in drug delivery including drug delivery systems, in vitro and in vivo tests.

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