Customized Novel Design of 3D Printed Pregabalin Tablets for Intra-Gastric Floating and Controlled Release Using Fused Deposition Modeling

Three-dimensional (3D) printing has been recently employed in the design and formulation of various dosage forms with the aim of on-demand manufacturing and personalized medicine. In this study, we formulated a floating sustained release system using fused deposition modeling (FDM). Filaments were prepared using hypromellose acetate succinate (HPMCAS), polyethylene glycol (PEG 400) and pregabalin as the active ingredient. Cylindrical tablets with infill percentages of 25%, 50% and 75% were designed and printed with the FDM printer. An optimized formulation (F6) was designed with a closed bottom layer and a partially opened top layer. Filaments and tablets were characterized by means of fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and thermogravimetric analysis (TGA). The results show that the processing condition did not have a significant effect on the stability of the drug and the crystallinity of the drug remained even after printing. A dissolution study revealed that drug release is faster in an open system with low infill percentage compared to closed systems and open systems with a high infill ratio. The optimized formulation (F6) with partially opened top layer showed zero-order drug release. The results show that FDM printing is suitable for the formulation of floating dosage form with the desired drug release profile.

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Development of three-dimensional printing filaments based on poly(lactic acid)/hydroxyapatite composites with potential for tissue engineering

Journal of Composite Materials ◽

10.1177/0021998320988568 ◽

2021 ◽

pp. 002199832098856

Author(s):

Marcela Piassi Bernardo ◽

Bruna Cristina Rodrigues da Silva ◽

Luiz Henrique Capparelli Mattoso

Keyword(s):

Tissue Engineering ◽

Lactic Acid ◽

Fused Deposition Modeling ◽

Three Dimensional ◽

Poly Lactic Acid ◽

Scanning Calorimetry ◽

Three Dimensional Printing ◽

Fused Deposition ◽

Deposition Modeling ◽

3D Printed

Injured bone tissues can be healed with scaffolds, which could be manufactured using the fused deposition modeling (FDM) strategy. Poly(lactic acid) (PLA) is one of the most biocompatible polymers suitable for FDM, while hydroxyapatite (HA) could improve the bioactivity of scaffold due to its chemical composition. Therefore, the combination of PLA/HA can create composite filaments adequate for FDM and with high osteoconductive and osteointegration potentials. In this work, we proposed a different approache to improve the potential bioactivity of 3D printed scaffolds for bone tissue engineering by increasing the HA loading (20-30%) in the PLA composite filaments. Two routes were investigated regarding the use of solvents in the filament production. To assess the suitability of the FDM-3D printing process, and the influence of the HA content on the polymer matrix, thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) were performed. The HA phase content of the composite filaments agreed with the initial composite proportions. The wettability of the 3D printed scaffolds was also increased. It was shown a greener route for obtaining composite filaments that generate scaffolds with properties similar to those obtained by the solvent casting, with high HA content and great potential to be used as a bone graft.

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Extrusion-Based 3D Printing for Pharmaceuticals: Contemporary Research and Applications

Current Pharmaceutical Design ◽

10.2174/1381612825666190110155931 ◽

2019 ◽

Vol 24 (42) ◽

pp. 4991-5008 ◽

Cited By ~ 9

Author(s):

Mohammed S. Algahtani ◽

Abdul Aleem Mohammed ◽

Javed Ahmad

Keyword(s):

Cosmetic Surgery ◽

Fused Deposition Modeling ◽

Personalised Medicine ◽

Organ Transplant ◽

Three Dimensional ◽

Dosage Forms ◽

Release Profile ◽

Small Scale ◽

Drug Release Profile ◽

Fused Deposition

Three-dimensional printing (3DP) has a significant impact on organ transplant, cosmetic surgery, surgical planning, prosthetics and other medical fields. Recently, 3 DP attracted the attention as a promising method for the production of small-scale drug production. The knowledge expansion about the population differences in metabolism and genetics grows the need for personalised medicine substantially. In personalised medicine, the patient receives a tailored dose and the release profile is based on his pharmacokinetics data. 3 DP is expected to be one of the leading solutions for the personalisation of the drug dispensing. This technology can fabricate a drug-device with complicated geometries and fillings to obtain the needed drug release profile. The extrusionbased 3 DP is the most explored method for investigating the feasibility of the technology to produce a novel dosage form with properties that are difficult to achieve using the conventional industrial methods. Extrusionbased 3 DP is divided into two techniques, the semi-solid extrusion (SSE) and the fused deposition modeling (FDM). This review aims to explain the extrusion principles behind the two techniques and discuss their capabilities to fabricate novel dosage forms. The advantages and limitations observed through the application of SSE and FDM for fabrication of drug dosage forms were discussed in this review. Further exploration and development are required to implement this technology in the healthcare frontline for more effective and personalised treatment.

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Synthesis and properties of modified PBT for FDM

Rapid Prototyping Journal ◽

10.1108/rpj-12-2015-0197 ◽

2017 ◽

Vol 23 (4) ◽

pp. 804-810 ◽

Cited By ~ 2

Author(s):

Shiqing Cao ◽

Dandan Yu ◽

Weilan Xue ◽

Zuoxiang Zeng ◽

Wanyu Zhu

Keyword(s):

Mechanical Properties ◽

Impact Strength ◽

Fused Deposition Modeling ◽

Complex Structure ◽

Three Dimensional ◽

Sebacic Acid ◽

Wire Drawing ◽

Content Type ◽

Fused Deposition ◽

Deposition Modeling

Purpose The purpose of this paper is to prepare a new modified polybutylene terephalate (MPBT) for fused deposition modeling (FDM) to increase the variety of materials compatible with printing. And the printing materials can be used to print components with a complex structure and functional mechanical parts. Design/methodology/approach The MPBT, poly(butylene terephalate-co-isophthalate-co-sebacate) (PBTIS), was prepared for FDM by direct esterification and subsequent polycondensation using terephthalic acid (PTA), isophthalic acid (PIA), sebacic acid (SA) and 1,4-butanediol (BDO). The effects of the content of PIA (20-40 mol%) on the mechanical properties of PBTIS were investigated when the mole per cent of SA (αSA) is zero. The effects of αSA (0-7mol%) on the thermal, rheological and mechanical properties of PBTIS were investigated at nPTA/nPIA = 7/3. A desktop wire drawing and extruding machine was used to fabricate the filaments, whose printability and anisotropy were tested by three-dimensional (3D) printing experiments. Findings A candidate content of PIA introducing into PBT was obtained to be about 30 per cent, and the Izod notched impact strength of PBTIS increased with the increase of αSA. The results showed that the PBTIS (nPTA/nPIA = 7/3, αSA = 3-5mol%) is suitable for FDM. Originality/value New printing materials with good Izod notched impact strength were obtained by introducing PIA and SA (nPTA/nPIA = 7/3, αSA = 3-5 mol%) into PBT and their anisotropy are better than that of ABS.

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Accuracy of three-dimensional dental resin models created by fused deposition modeling, stereolithography, and Polyjet prototype technologies: A comparative study

The Angle Orthodontist ◽

10.2319/071117-460.1 ◽

2018 ◽

Vol 88 (3) ◽

pp. 363-369 ◽

Cited By ~ 18

Author(s):

Raymund E. Rebong ◽

Kelton T. Stewart ◽

Achint Utreja ◽

Ahmed A. Ghoneima

Keyword(s):

Fused Deposition Modeling ◽

Three Dimensional ◽

Vertical Plane ◽

Physical Models ◽

Dental Resin ◽

Fused Deposition ◽

Deposition Modeling ◽

School Of Dentistry ◽

Plaster Models ◽

Plaster Casts

ABSTRACT Objectives: The aim of this study was to assess the dimensional accuracy of fused deposition modeling (FDM)–, Polyjet-, and stereolithography (SLA)–produced models by comparing them to traditional plaster casts. Materials and A total of 12 maxillary and mandibular posttreatment orthodontic plaster casts were selected from the archives of the Orthodontic Department at the Indiana University School of Dentistry. Plaster models were scanned, saved as stereolithography files, and printed as physical models using three different three-dimensional (3D) printers: Makerbot Replicator (FDM), 3D Systems SLA 6000 (SLA), and Objet Eden500V (Polyjet). A digital caliper was used to obtain measurements on the original plaster models as well as on the printed resin models.Methods: Results: Comparison between the 3D printed models and the plaster casts showed no statistically significant differences in most of the parameters. However, FDM was significantly higher on average than were plaster casts in maxillary left mixed plane (MxL-MP) and mandibular intermolar width (Md-IMW). Polyjet was significantly higher on average than were plaster casts in maxillary intercanine width (Mx-ICW), mandibular intercanine width (Md-ICW), and mandibular left mixed plane (MdL-MP). Polyjet was significantly lower on average than were plaster casts in maxillary right vertical plane (MxR-vertical), maxillary left vertical plane (MxL-vertical), mandibular right anteroposterior plane (MdR-AP), mandibular right vertical plane (MdR-vertical), and mandibular left vertical plane (MdL-vertical). SLA was significantly higher on average than were plaster casts in MxL-MP, Md-ICW, and overbite. SLA was significantly lower on average than were plaster casts in MdR-vertical and MdL-vertical. Conclusions: Dental models reconstructed by FDM technology had the fewest dimensional measurement differences compared to plaster models.

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An investigation into the use of polymer blends to improve the printability of and regulate drug release from pharmaceutical solid dispersions prepared via fused deposition modeling (FDM) 3D printing

European Journal of Pharmaceutics and Biopharmaceutics ◽

10.1016/j.ejpb.2016.08.016 ◽

2016 ◽

Vol 108 ◽

pp. 111-125 ◽

Cited By ~ 81

Author(s):

Muqdad Alhijjaj ◽

Peter Belton ◽

Sheng Qi

Keyword(s):

3D Printing ◽

Drug Release ◽

Polymer Blends ◽

Fused Deposition Modeling ◽

Solid Dispersions ◽

Fused Deposition ◽

Deposition Modeling

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Exploring tablet design options for tailoring drug release and dose via fused deposition modeling (FDM) 3D printing

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2020.119987 ◽

2020 ◽

Vol 591 ◽

pp. 119987

Author(s):

Guluzar Gorkem Buyukgoz ◽

David Soffer ◽

Jackenson Defendre ◽

Gia M. Pizzano ◽

Rajesh N. Davé

Keyword(s):

3D Printing ◽

Drug Release ◽

Fused Deposition Modeling ◽

Fused Deposition ◽

Deposition Modeling ◽

Design Options

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3D-Printed Soft Structure of Polyurethane and Magnetorheological Fluid: A Proof-of-Concept Investigation of its Stiffness Tunability

Micromachines ◽

10.3390/mi10100655 ◽

2019 ◽

Vol 10 (10) ◽

pp. 655 ◽

Cited By ~ 1

Author(s):

Seong-Woo Hong ◽

Ji-Young Yoon ◽

Seong-Hwan Kim ◽

Sun-Kon Lee ◽

Yong-Rae Kim ◽

...

Keyword(s):

Fused Deposition Modeling ◽

Permanent Magnets ◽

Thermoplastic Polyurethane ◽

Three Dimensional ◽

Magnetorheological Fluid ◽

Three Dimensional Printing ◽

Fused Deposition ◽

Deposition Modeling ◽

3D Printed ◽

Dimensional Printing

In this study, a soft structure with its stiffness tunable by an external field is proposed. The proposed soft beam structure consists of a skin structure with channels filled with a magnetorheological fluid (MRF). Two specimens of the soft structure are fabricated by three-dimensional printing and fused deposition modeling. In the fabrication, a nozzle is used to obtain channels in the skin of the thermoplastic polyurethane, while another nozzle is used to fill MRF in the channels. The specimens are tested by using a universal tensile machine to evaluate the relationships between the load and deflection under two different conditions, without and with permanent magnets. It is empirically shown that the stiffness of the proposed soft structure can be altered by activating the magnetic field.

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