Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs

Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals. The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to manufacture flexible dosage forms with acceptable mass and content uniformity. Formulation development was supported by physicochemical characterization of the inks and final dosage forms. The printing of haloperidol (HAL) discs was performed using a prototype stencil printer. Ink development comprised of investigations of ink rheology in combination with printability assessment. The results show that stencil printing can be used to manufacture HAL doses in the therapeutic treatment range for 6–17 year-old children. The therapeutic HAL dose was achieved for the discs consisting of 16% of hydroxypropyl methylcellulose (HPMC) and 1% of lactic acid (LA). The formulation pH remained above pH 4 and the results imply that the drug was amorphous. Linear dose escalation was achieved by an increase in aperture area of the print pattern, while keeping the stencil thickness fixed. Disintegration times of the orodispersible discs printed with 250 and 500 µm thick stencils were below 30 s. In conclusion, stencil printing shows potential as a manufacturing method of pharmaceuticals.

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FORMULATION DEVELOPMENT AND EVALUATION OF AN IN SITU OPHTHALMIC GELLING SYSTEM OF BRIMONIDINE TARTRATE AND TIMOLOL MALEATE FOR THE TREATMENT OF GLAUCOMA

INDIAN DRUGS ◽

10.53879/id.54.02.10854 ◽

2017 ◽

Vol 54 (02) ◽

pp. 76-78

Author(s):

A Shirodker ◽

◽

S. Bhangle ◽

R. Gude

Keyword(s):

Hydroxypropyl Methylcellulose ◽

In Vitro Release ◽

Content Uniformity ◽

Formulation Development ◽

Timolol Maleate ◽

Release Studies ◽

Brimonidine Tartrate ◽

In Situ Gelling

The present study involved formulation of an in situ gelling system of brimonidine tartrate and timolol maleate for the treatment of glaucoma. Carbopol® 980 NF, xanthum gum and hydroxypropyl methylcellulose K4 M were used as polymers. The prepared in situ gelling systems were evaluated for clarity, appearance, texture analysis, pH, viscosity, rheological properties, in vitro gelation, isotonicity, drug content uniformity, in vitro release studies, microbiological evaluation, ex vivo release studies and stability testing. The results of the attenuated total reflectance spectroscopy and differential scanning calorimetry studies confirmed that there is no incompatibility between the drugs and the excipients. The formulations exhibited pseudoplastic rheology and formulation 3 showed the highest release of both the drugs from the formulation. The stability studies showed that the formulation was stable over the given period of time. Thus, it is evident that the in situ gelling system is a promising drug delivery system for the treatment of glaucoma.

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DOSAGE FORM DEVELOPMENT AND PRELIMINARY PHYSICOCHEMICAL CHARACTERIZATION OF TRIKANTAKADI KVATHA

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10s4.21336 ◽

2017 ◽

Vol 10 (16) ◽

pp. 52

Author(s):

Swati Sharma ◽

Dileep Singh Baghel ◽

Saurabh Singh ◽

Sachin Kumar Singh

Keyword(s):

Physicochemical Parameters ◽

Dosage Form ◽

Classical Method ◽

Physicochemical Characterization ◽

Dosage Forms ◽

Remarkable Difference ◽

Standard Value ◽

Form Development ◽

Layer Chromatography

Objective: This is aimed to study the development of different dosage form and physicochemical characterization of Trikantakadi Kvatha (TK).Methods: Stability, shelf life, non-convenient, and large dosages administration are the major concern for Kvatha. To overcome these problems, an effort has been made to modify the formulation without changing its efficacy into various dosage forms such as tablet, syrup, and tincture. Comparative pharmacognostic, physicochemical, and phytochemical parameters of crude herbs and prepared formulations were investigated. TK was prepared by classical method mentioned in literature and converted into TK syrup, TK Ghana vati, and Trikantakadi tincture (TT). Precaution should be taken during the processing of formulations. TT placed at a dark place in airtight container.Results: Physicochemical and phytochemical investigations are not shown any remarkable variations with various prepared dosage forms. The Rf range observed between the 0.08 and 0.80 follows the standard value when compared with the reference of plant drug used for the preparation of dosage form.Conclusion: The prepared dosages forms were not exhibited any remarkable difference according to thin-layer chromatography studies and physicochemical parameters. However, the developed dosage forms are more stable than kvatha.

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FORMULATION DEVELOPMENT AND EVALUATION OF FAST DISSOLVING FILMS OF EBASTINE

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2020v12i5.39782 ◽

2020 ◽

pp. 111-115

Author(s):

TEJASVI TORGAL ◽

SHWETA BORKAR ◽

PRASHANT BHIDE ◽

ASMITA ARONDEKAR

Keyword(s):

Hydroxypropyl Methylcellulose ◽

Rapid Onset ◽

Content Uniformity ◽

Formulation Development ◽

Onset Of Action ◽

Polyethylene Glycol 400 ◽

In Vitro Drug Release ◽

First Order Kinetics ◽

Percentage Release

Objective: To overcome the limitations of fast dissolving tablets, a novel fast dissolving film of ebastine was formulated for attaining quick onset of action, aiding in the enhancement of bioavailability favorable in severe conditions of allergies. Methods: Films of ebastine were prepared by the solvent casting method using hydroxypropyl methylcellulose E-15, hydroxypropyl methylcellulose K-4 as a film base with different concentrations of crospovidone as superdisintegrant and polyethylene glycol-400 as a plasticizer. Further physical characteristics such as uniformity of weight, thickness, and drug content uniformity, tensile strength, folding endurance, percentage elongation, surface pH, disintegration and in vitro drug release were evaluated. Results: The optimized formulations with film base hydroxypropyl methylcellulose E-15 and hydroxypropyl methylcellulose K-4 containing 8% crospovidone showed 99.34 % and 97.42 % of maximum cumulative percentage release respectively exhibiting first order kinetics. However, no significant change was observed in stability studies. Conclusion: The concept of formulating fast dissolving films of ebastine offers a suitable approach in exhibiting rapid onset of action with improved delivery.

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CHARACTERIZATION OF DRUGS ENCAPSULATED INTO MESOPOROUS SILICA

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2019v11i6.35431 ◽

2019 ◽

pp. 7-11

Author(s):

ARIF BUDIMAN

Keyword(s):

Water Solubility ◽

Drug Loading ◽

Physicochemical Characterization ◽

Amorphous State ◽

Molecular State ◽

Water Soluble ◽

Crystal Nucleation ◽

Formulation Development ◽

Scanning Calorimetry

Solubility of the drug has a strong influence to achieve higher bioavailability of the drug in systemic circulation. More than 70% NCEs (new chemical entities) are hydrophobic, and practically difficult into solid formulation due to their poor water solubility. Mesoporous silicas (MSP) have been used for drug delivery system, especially for poorly water-soluble drugs. Encapsulation and interaction of drugs in MSP can enhance the delivery and maintain the stability of the drug. However, the characterization of the drug in MSP is necessary to confirm its molecular state. In this review, we present an overview of reports related to the characterization of drug encapsulated into MSP. Encapsulation of drugs in MSP can prevent recrystallization of drugs due to its inhibition of crystal nucleation. A porous material in MSP can maintain the drug in a physically stable amorphous state. The preventing of drug crystallization in MSP can enhance the solubility and the dissolution rate of drug. Therefore, in this work, attempts have been made to understand the molecular state of the drug in MSP. The physicochemical characterization of drug by transmission electron microscopy (TEM), scanning electron microscope (SEM), differential scanning calorimetry (DSC), fourier-transform infrared spectroscopy (FTIR), powder x-ray diffraction (PXRD) and thermogravimetric analysis (TGA) were discussed. The effect of solvent and methods of drug loading and the effect of the shape of MSP on release profiles are also presented. Overall, this review provides information about the characterization of drug encapsulated into MSP which will be useful in pharmaceutical formulation development.

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Risk Assessment and Physicochemical Characterization of a Metastable Dihydrate API Phase for Intravenous Formulation Development

Journal of Pharmaceutical Sciences ◽

10.1002/jps.22225 ◽

2010 ◽

Vol 99 (12) ◽

pp. 4973-4981 ◽

Cited By ~ 4

Author(s):

Christopher J. Mortko ◽

Agam R. Sheth ◽

Narayan Variankaval ◽

Li Li ◽

Brian T. Farrer

Keyword(s):

Risk Assessment ◽

Physicochemical Characterization ◽

Formulation Development ◽

Intravenous Formulation

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A COMPARATIVE STUDY OF KALYANAKA KSHARA PREPARED BY PUTA METHOD AND FURNACE METHOD TO ASSESS ITS PHYSICOCHEMICAL PROPERTIES

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.120113 ◽

2021 ◽

Vol 12 (1) ◽

pp. 53-58

Author(s):

Neethu Indukumar ◽

G Jai

Keyword(s):

Physicochemical Characterization ◽

Dosage Forms ◽

Basic Form ◽

Muffle Furnace ◽

Animal Products ◽

Minimal Dose ◽

Strong Action ◽

Shelf Life Stability ◽

Day By Day

Ayurveda, the science of life is as old as the Vedic age and now a days Ayurvedic medicines are becoming popular day by day all across the world. The Ayurvedic therapeutics are mainly based on various kinds of dosage forms. Panchavidha kashaya kalpana is the basic form and many formulations are developed over time having long shelf life, stability, strong action etc. Kshara kalpana is the alkaline substance obtained from the ash of plants, minerals and animal products and has been widely used due to its minimal dose and potential action. Kalyanaka Kshara is a widely used formulation mentioned in our classics which is prepared by Antardhooma vidhi. In the present study Kalyanaka Kshara has been prepared using puta method as well as using muffle furnace. Physicochemical characterization of both the samples were done.

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Glossary of terms related to pharmaceutics (IUPAC Recommendations 2009)

Pure and Applied Chemistry ◽

10.1351/pac-rec-04-10-14 ◽

2009 ◽

Vol 81 (5) ◽

pp. 971-999 ◽

Cited By ~ 5

Author(s):

Eli Breuer ◽

Mukund Shankar Chorghade ◽

János Fischer ◽

Gershon Golomb

Keyword(s):

Biological Sciences ◽

Drug Delivery ◽

Crucial Role ◽

Physicochemical Characterization ◽

Pharmaceutical Preparations ◽

Dosage Forms ◽

Unit Operations ◽

Scientific Disciplines ◽

Multidisciplinary Nature

This Glossary of Terms in Pharmaceutics is needed by practitioners in the field of pharmaceutics as this field fulfills an important and crucial role, different from the roles of other scientific disciplines involved in the drug-making process. The glossary contains 168 definitions used in pharmaceutics. These are related to various aspects of this discipline such as: (1) physicochemical characterization of pharmaceutical preparations and the active ingredients they contain; (2) unit operations used in the practice of pharmaceutics; (3) terms related to the various dosage forms; (4) terms related to the various modes and routes of drug delivery; (5) terms used in pharmacokinetics and biopharmaceutics in general, and additional miscellaneous terms. The field of pharmaceutics itself is of a multidisciplinary nature as its practitioners come from a variety of disciplines, such as chemistry or various biological sciences, thus a glossary containing authoritative definitions would be useful for them. The terms used in pharmaceutics are rarely covered by existing glossaries, and in the cases they are, their definitions are often inappropriate for the field of pharmaceutics and require new or modified definitions to better fit the new context.

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