scholarly journals Excipients in the Paediatric Population: A Review

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 387
Author(s):  
Khadija Rouaz ◽  
Blanca Chiclana-Rodríguez ◽  
Anna Nardi-Ricart ◽  
Marc Suñé-Pou ◽  
Dèbora Mercadé-Frutos ◽  
...  
Keyword(s):  
Theoretical Study ◽  
Scientific Literature ◽  
Paediatric Population ◽  
Regulatory Agencies ◽  
Orally Disintegrating Tablets ◽  
Pharmaceutical Form ◽  
Safety And Toxicity ◽  
Drug Regulatory Agencies ◽  
The One ◽  
Population Databases

This theoretical study seeks to critically review the use of excipients in the paediatric population. This study is based on the rules and recommendations of European and American drug regulatory agencies. On the one hand, this review describes the most frequent excipients used in paediatric medicine formulations, identifying the compounds that scientific literature has marked as potentially harmful regarding the side effects generated after exposure. On the other hand, this review also highlights the importance of carrying out safety -checks on the excipients, which, in most cases, are linked to toxicity studies. An excipient in the compilation of paediatric population databases is expected to target safety and toxicity, as in the STEP database. Finally, a promising pharmaceutical form for child population, ODT (Orally Disintegrating Tablets), will be studied.

Alternativas farmacéuticas: ¿pueden ser intercambiables?

2020 ◽  
Vol 2 (2) ◽  
pp. 38-42
Author(s):  
Miriam del Carmen Carrasco-Portugal ◽  
Francisco Javier Flores-Murrieta
Keyword(s):  
Generic Substitution ◽  
In Vivo Studies ◽  
Regulatory Agencies ◽  
European Medicines Agency ◽  
Reference Formulation ◽  
Active Moiety ◽  
Significant Difference ◽  
Pharmaceutical Form ◽  
Extent Of Absorption

Pharmaceutical alternatives are products with the same active moiety, but different salt, ester or pharmaceutical form. Regulatory agencies have different criteria for this kind of drug. The European Medicines Agency (EMA) accepts the generic substitution using these alternatives, whereas the Food and Drug Administration (FDA) only authorizes generic substitution of pharmaceutical equivalents. The objective of this paper is to describe some relevant aspects that should be considered before deciding on making a generic substitution with pharmaceutical alternatives. It is important to note that a pharmaceutical alternative must show no significant difference in the rate and extent of absorption (bioequivalence) in a well-conducted in vivo study when compared with the reference formulation. Current Mexican regulations state that generic substitution is possible using pharmaceutical alternatives when bioequivalence is demonstrated in in vivo studies conducted under the NOM-177-SSA1-2013 criteria. In conclusion, generic substitution with pharmaceutical alternatives is possible if these products demonstrate in vivo bioequivalence when compared with the reference product.

DOCUMENTARY ANIMATED: GENESIS AND SPECIFICITY (PREVIEW ARTICLE)

2021 ◽  
pp. 96-115
Author(s):  
Natalia G. Krivulya ◽  
Keyword(s):  
Scientific Literature ◽  
Cultural Practice ◽  
Academic Community ◽  
Classification Systems ◽  
Narrative Strategies ◽  
Research Strategies ◽  
Dual Nature ◽  
Animated Film ◽  
The One ◽  
New Research

Animated documentary is becoming one of the fastest growing phenomena of modern screen art in the post-truth era. The review and analysis of scientific works devoted to animated documentary is seen as relevant both for the further development of scientific thought and the search for new research strategies that expand the problem field, and for the practical sphere. The research was conducted on the basis of a review and analysis of scientific literature (monographs and articles in international journals included in electronic research system international databases Scopus, Web of Science, eLibrary.ru) in English, Spanish and Russian for the period 1997-2019. The novelty of the review article is not only an attempt to present a systematic view of animated documentary as a phenomenon of screen art, but also to identify and systematize the areas in which scientific discussions are conducted. It introduces the reader to theoretical views on the terminology, Genesis, specifics, nature, and classification systems of documentary animation. Animated documentary appeared when the cinema was just taking first steps but its development began in the 1980s. At this time, animation begins to take an interest in reality, inner peace, and socially taboo topics. Since the 1990s, the foundations of animated documentary are laid, narrative strategies are developed, and a new language are actively sought. Interest in animated documentary from the scientific community arose only in the 2000s. On the one hand, it has been manifested by the increasing role of documentation in the art, which has taken on an attraction character since the advent of digital technology; on the other hand, and as a consequence of the convergence of screen arts and the emergence of hybridization trends. The academic community has focused around developing definitions and understanding what can be attributed to the field of documentary animation. By 2010, the scientific literature focused on issues related to the specifics of animated documentary, ways of presenting reality, and indexing. By the mid-2010s, animation is becoming the subject of interdisciplinary study. At this time, there are develop tools for analyzing works of animated documentaries, and its genre system begins to build. One of the main features of animated documentaries is hybridity. Its dual nature is born of fluctuations between the certainty of facts and artistic embodiment. The problems of authenticity and representation of reality become one of the most controversial topics in an animated film. The work provides an overview of theoretical studies on the genesis, history and particularities of animadoc. The theoretical texts identify three approaches that form the main directions in the analysis of animated documentary. The first group of researchers analyzes this phenomenon and its nature based on the theories of documentaries and the transformation with the advent of digital technologies, of the concepts of reality, authenticity and fact (document). The second group of authors considers animation as a phenomenon of modern animation that arose as a result of technological renewal and changes in its role as a socio-cultural practice. A third group of scientists believes that animadoc is a post-postmodern phenomenon that arose as a means of presenting a world in which there is mobility of borders and cyberspace becomes a new reality. The review allows us to conclude that animated documentary is a manifestation of a new mode of postphotographic vision of a reflexive nature, in which the imagination that refracts images of reality becomes of primary importance. Despite the interest in it from the academic community and the emergence of theoretical works, the study of this phenomenon is only at the initial stage. Despite the interest in it from the academic community, there is a small number of deep theoretical works caused by the hybrid nature of the phenomenon itself, the imperfection of working models and methods for analyzing representational strategies, and the problems of forming a conceptual apparatus.

scholarly journals Prosocialaus elgesio formavimasis universiteto liberalaus ugdymo procese

2018 ◽  
Vol 1 (11) ◽  
pp. 1-10
Author(s):  
Enrika Kromerova
Keyword(s):  
Liberal Education ◽  
Scientific Literature ◽  
Moral Dilemmas ◽  
Prosocial Behaviour ◽  
Conceptual Level ◽  
Educational Approach ◽  
Theory Of Education ◽  
The One ◽  
Educational Paradigms ◽  
Education Process

Research background. Today prosociality is an indisputably integral part of the prosperity of society. Analysing the complex and sophisticated issues of lifelong learning of a person, a holistic and high conceptual level theory of education is needed, which is based not only on the one-fold examination of the phenomenon of education, but also on a system of philosophy-based educational paradigms. Thus, liberal education is regarded as one of the essential and fundamental opportunities for the realization of higher education, thinking about the future of society. The above-mentioned aspects make the problematic question possible to be raised: how is prosocial behaviour formed in the liberal education process at university? The article analyses the concept and essence of prosocial behaviour and examines the value basis of liberal education in order to reveal the possibilities of liberal education that determines prosocial behaviour at university. R. Barnett’s (1990) liberal educational approach and conservative and radical concepts are used in this research. The aim was to reveal the formation of prosocial behaviour in the process of university liberal education. Method. The method of scientific literature analysis was used in the research in order to reveal the formation of prosocial behaviour during the liberal education process at university. Results and conclusions. The elements of the formation of prosocial behaviour are encoded in R. Barnett's (1990) liberal educational concepts that cannot exist separately, because the components of both concepts (development of critical thinking, freedom to make decisions, student self-expression, the ability to deal with moral dilemmas) actively and purposefully formulate human prosocial reasoning and behaviour .

scholarly journals ON THE SPECIFICITY OF FUNCTIONING OF THE NUMERALS IN THE NORTHERN DIALECTS OF THE UDMURT LANGUAGE

2020 ◽  
Vol 30 (5) ◽  
pp. 804-812
Author(s):  
L.L. Karpova
Keyword(s):  
Scientific Literature ◽  
The Other ◽  
Literary Language ◽  
Empirical Base ◽  
Language Area ◽  
The One ◽  
Limited Diffusion

The paper aims to analyze features of the numerals in the Northern dialects of the Udmurt language. The empirical base of the research is the language materials of the author’s dialectological expeditions to the areas of Northern Udmurt. The relevance of the study is determined by the importance of information about the originality of the Udmurt dialects, common in the Northern language area and having insufficient coverage in the scientific literature. The paper highlights specific features of the Northern Udmurt dialects on the one hand and features with limited diffusion in certain microsystems of studied dialects on the other. The study demonstrates that general characteristics of the numerals in these dialects do not show great differences from those of literary language. The author focuses on features that are highlighted in the phonetic design of individual numerals. Specific phenomena in the formation and use of certain numbering words are noted. The territorial prevalence of dialect modifications of the numerals in the Northern dialect space of the Udmurt language is also revealed. Consistent comparison of the language facts of Northern Udmurt dialects with similar phenomena in other dialects of Udmurt is made.

Letter to the Editor

PEDIATRICS ◽  
1994 ◽  
Vol 93 (1) ◽  
pp. 154-154
Author(s):  
Alejandro Hoberman ◽  
Ellen R. Wald
Keyword(s):  
Private Practice ◽  
Occupational Safety ◽  
Clinical Laboratory ◽  
Regulatory Agencies ◽  
Health Administration ◽  
Safety And Health ◽  
Effective Care ◽  
Laboratory Procedures ◽  
The One ◽  
Clinical Laboratory Improvement Amendments

Dr Murray correctly points out that the concerns of office-based pediatricians regarding regulations imposed by the Clinical Laboratory Improvement Amendments (CLIA) and Occupational Safety and Health Administration (OSHA) greatly affect the likely implementation of "new laboratory procedures" within the private practice sector. Although these regulatory agencies, on the one hand, intend to assure quality control when evaluating specimens and on the other hand, safety for patients and employees, they are often perceived as obstacles to effective care.

A Critical Analysis of the Limitations and Effects of the Brazilian National Broadband Plan

2013 ◽  
pp. 255-274
Author(s):  
André Lemos ◽  
Francisco Paulo Jamil Almeida Marques
Keyword(s):  
Economic Growth ◽  
Twentieth Century ◽  
Critical Analysis ◽  
The Other ◽  
Regulatory Agencies ◽  
Net Neutrality ◽  
Political Effects ◽  
State Monopoly ◽  
Telecommunications Services ◽  
The One

This chapter examines the limitations and the socio-political effects of the Brazilian National Broadband Plan (PNBL: is its Portuguese acronym). The discussion considers the main transformations witnessed in the telecommunications landscape in Brazil during the second half of the twentieth century. On the one hand, the end of state monopoly of telecommunications services and the provision of such services by the private sector called for greater investments in infrastructure. On the other hand, the Brazilian regulatory agencies have failed to lower prices, promote competition, and spread broadband access to remote and underserved areas. The PNBL was launched in order to deal with these difficulties. The plan, however, has at least three important problems: (1) the low-speed connection offered to users, (2) the unattractive prices, and (3) the lack of reflection on issues such as net neutrality. The text argues that only by taking such issues into consideration will the plan ensure innovation, economic growth, diversity, and freedom of access to information.

Events Reconsidered

2003 ◽  
Author(s):  
J. S. Weiner ◽  
Chris Stringer
Keyword(s):  
Scientific Literature ◽  
British Museum ◽  
Primary Sources ◽  
The Public ◽  
Public Meeting ◽  
Real Importance ◽  
New Form ◽  
To Come ◽  
The One ◽  
Work Done

It is unfortunately not possible to follow in any detail every stage of Smith Woodward’s activities at Piltdown. No diaries or note-books exist of the work done, there is nowhere a complete record of the various finds as they were made. Woodward kept copies of very few of his own letters and we have only the letters written to him and now preserved at the British Museum. When the American palaeontologist Osborn came over in 1920, Woodward dictated some notes which help to allocate the various discoveries. Apart from these notes and the one-sided record of the correspondence, there are only the reports in the scientific literature and popular lectures on Piltdown as primary sources. Woodward does not appear in general to have been a secretive man, but over the Piltdown material he went to some lengths to keep the whole affair as quiet as possible until near the time of the public meeting in December 1912. He did not consult any of his colleagues in the Museum about the finds or about the interpretation he was to place on them. Mr. Hinton says that to his colleagues at South Kensington Woodward’s diagnosis of E. dawsoni came as a surprise mingled with some dismay, for there was much scepticism of the new form amongst his museum colleagues, including Oldfield Thomas and Hinton himself. They would have advised caution, he says. Keith knew nothing of the events in Sussex until rumours reached him in November. He wrote asking for a view of the exciting material, but on his visit on 2 December to the Museum he was received rather coldly and allowed a short twenty minutes. But, judging from Dawson’s letters in 1912, it seems fair to say that Woodward was merely seeking to avoid a premature disclosure, for he had decided early on that Piltdown would indeed prove a sensational event. Woodward did not want any of Dawson’s ‘lay’ friends to come along on his first visit to the gravel when he had yet to make up his mind about the real importance of Dawson’s find and of the necessity for systematic excavation.

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