scholarly journals Improved Bioavailability of Poorly Soluble Drugs through Gastrointestinal Muco-Adhesion of Lipid Nanoparticles

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1817
Author(s):  
Sui Ling Janet Tan ◽  
Nashiru Billa
Keyword(s):  
Drug Delivery Systems ◽  
Lipid Nanoparticles ◽  
Polymeric Coating ◽  
Poorly Soluble Drugs ◽  
Systemic Delivery ◽  
Lymphatic Absorption ◽  
Systemic Bioavailability ◽  
First Pass ◽  
Poorly Soluble ◽  
Lymphatic Pathway

Gastrointestinal absorption remains indispensable in the systemic delivery of most drugs, even though it presents several challenges that, paradoxically, may also provide opportunities that can be exploited to achieve maximal bioavailability. Drug delivery systems made from nanoparticle carriers and especially, lipid carriers, have the potential to traverse gastrointestinal barriers and deploy in the lymphatic pathway, which aptly, is free from first pass via the liver. Several poorly soluble drugs have presented improved systemic bioavailability when couriered in lipid nanoparticle carriers. In this review, we propose an additional frontier to enhancing the bioavailability of poorly soluble drugs when encapsulated in lipid nano-carriers by imparting muco-adhesion to the particles through application of appropriate polymeric coating to the lipid carrier. The combined effect of gastrointestinal muco-adhesion followed by lymphatic absorption is a promising approach to improving systemic bioavailability of poorly soluble drugs following oral administration. Evidence to the potential of this approach is backed-up by recent studies within the review.

Self-microemulsion Technology for Water-insoluble Drug Delivery

2019 ◽  
Vol 15 (6) ◽  
pp. 576-588 ◽  
Author(s):  
Beibei Yan ◽  
Yu Gu ◽  
Juan Zhao ◽  
Yangyang Liu ◽  
Lulu Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Aqueous Solubility ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
New Chemical Entities ◽  
Poorly Soluble ◽  
Water Insoluble Drug ◽  
Semi Solid ◽  
Solidification Technology

: According to the drug discovery, approximately 40% of the new chemical entities show poor bioavailability due to their low aqueous solubility. In order to increase the solubility of the drugs, self-micro emulsifying drug delivery systems (SMEDDS) are considered as an ideal technology for enhancing the permeability of poorly soluble drugs in GI membranes. The SMEDDS are also generally used to enhance the oral bioavailability of the hydrophobic drugs. At present, most of the self-microemulsion drugs are liquid dosage forms, which could cause some disadvantages, such as the low bioavailability of the traditional liquid SMEDDS. Therefore, solid self-micro emulsifying drug delivery systems (S-SMEDDS) have emerged widely in recent years, which were prepared by solidifying a semi-solid or liquid self-emulsifying (SE) ingredient into a powder in order to improve stability, treatment and patient compliance. The article gives a comprehensive introduction of the study of SMEDDS which could effectively tackle the problem of the water-insoluble drug, especially the development of solidification technology of SMEDDS. Finally, the present challenges and the prospects in this field were also discussed.

In VivoPrecipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems

2016 ◽  
Vol 13 (10) ◽  
pp. 3417-3426 ◽  
Author(s):  
P. J. Sassene ◽  
M. H. Michaelsen ◽  
M. D. Mosgaard ◽  
M. K. Jensen ◽  
E. Van Den Broek ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

Development of Solid Lipid Nanoparticles for Enhanced Solubility of Poorly Soluble Drugs

2010 ◽  
Vol 6 (6) ◽  
pp. 634-640 ◽  
Author(s):  
Sriharsha Gupta Potta ◽  
Sriharsha Minemi ◽  
Ravi Kumar Nukala ◽  
Chairmane Peinado ◽  
Dimitrios A. Lamprou ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Poorly Soluble Drugs ◽  
Solid Lipid ◽  
Enhanced Solubility ◽  
Poorly Soluble

scholarly journals Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1968
Author(s):  
Mina Zare ◽  
Karolina Dziemidowicz ◽  
Gareth R. Williams ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Strong Electric Field ◽  
Solid Dispersions ◽  
Electrospun Nanofibers ◽  
Amorphous Solid ◽  
Delivery Systems ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble ◽  
Biological And Medical Applications

Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.

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