scholarly journals Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

Polymers ◽  
2011 ◽  
Vol 3 (2) ◽  
pp. 779-811 ◽  
Author(s):  
Giulia Bonacucina ◽  
Marco Cespi ◽  
Giovanna Mencarelli ◽  
Gianfabio Giorgioni ◽  
Giovanni Filippo Palmieri
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

ISDN2014_0395: REMOVED: Self‐assembling MMP‐2 cleavable hydrogel drug delivery systems for neural tissue injury

2015 ◽  
Vol 47 (Part_A) ◽  
pp. 116-117
Author(s):  
K. Koss ◽  
M. Churchward ◽  
K. Todd ◽  
L.D. Unsworth
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Tissue Injury ◽  
Neural Tissue ◽  
Delivery Systems ◽  
Self Assembling

Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems

2017 ◽  
Vol 18 (5) ◽  
pp. 1532-1543 ◽  
Author(s):  
Hiteshri Makwana ◽  
Francesca Mastrotto ◽  
Johannes P. Magnusson ◽  
Darrell Sleep ◽  
Joanna Hay ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Delivery Systems for Birch-bark Triterpenoids and their Derivatives in Anticancer Research

2020 ◽  
Vol 27 (8) ◽  
pp. 1308-1336 ◽  
Author(s):  
Inese Mierina ◽  
Reinis Vilskersts ◽  
Māris Turks
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Biological Activities ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Birch Bark ◽  
Self Assembling ◽  
Wide Range ◽  
Synthetic Derivatives ◽  
Low Solubility

Birch-bark triterpenoids and their semi-synthetic derivatives possess a wide range of biological activities including cytotoxic effects on various tumor cell lines. However, due to the low solubility and bioavailability, their medicinal applications are rather limited. The use of various nanotechnology-based drug delivery systems is a rapidly developing approach to the solubilization of insufficiently bioavailable pharmaceuticals. Herein, the drug delivery systems deemed to be applicable for birch-bark triterpenoid structures are reviewed. The aforementioned disadvantages of birch-bark triterpenoids and their semi-synthetic derivatives can be overcome through their incorporation into organic nanoparticles, which include various dendrimeric systems, as well as embedding the active compounds into polymer matrices or complexation with carbohydrate nanoparticles without covalent bonding. Some of the known triterpenoid delivery systems consist of nanoparticles featuring inorganic cores covered with carbohydrates or other polymers. Methods for delivering the title compounds through encapsulation and emulsification into lipophilic media are also suitable. Besides, the birch-bark triterpenoids can form self-assembling systems with increased bio-availability. Even more, the self-assembling systems are used as carriers for delivering other chemotherapeutic agents. Another advantage besides increased bioavailability and anticancer activity is the reduced overall systemic toxicity in most of the cases, when triterpenoids are delivered with any of the carriers.

Studies on Properties and Drug Delivery Systems of PTMC-b-PEG-b-PTMC Block Copolymers

1998 ◽  
Vol 35 (5) ◽  
pp. 811-820 ◽  
Author(s):  
H. WANG ◽  
J. H. DONG ◽  
A. Y. QIU* ◽  
Z. W. GU
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Erratum: Corrigendum: Development and Characterization of Lecithin-based Self-assembling Mixed Polymeric Micellar (saMPMs) Drug Delivery Systems for Curcumin

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Ling-Chun Chen ◽  
Yin-Chen Chen ◽  
Chia-Yu Su ◽  
Wan-Ping Wong ◽  
Ming-Thau Sheu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

Self-assembling nanoscaled drug delivery systems composed of amphiphilic poly-N-vinylpyrrolidones

2007 ◽  
Vol 353 (41-43) ◽  
pp. 3969-3975 ◽  
Author(s):  
Andrey N. Kuskov ◽  
Michail I. Shtilman ◽  
Anastasia V. Goryachaya ◽  
Ravshan I. Tashmuhamedov ◽  
Alexander A. Yaroslavov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Self Assembling

scholarly journals Molecular Modelling Guided Modulation of Molecular Shape and Charge for Design of Smart Self-Assembled Polymeric Drug Transporters

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 141
Author(s):  
Sousa Javan Nikkhah ◽  
Damien Thompson
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Building Blocks ◽  
Molecular Shape ◽  
Delivery Systems ◽  
Smart Polymer ◽  
Drug Molecules ◽  
Self Assembling ◽  
Potential Energy Landscape

Nanomedicine employs molecular materials for prevention and treatment of disease. Recently, smart nanoparticle (NP)-based drug delivery systems were developed for the advanced transport of drug molecules. Rationally engineered organic and inorganic NP platforms hold the promise of improving drug targeting, solubility, prolonged circulation, and tissue penetration. However, despite great progress in the synthesis of NP building blocks, more interdisciplinary research is needed to understand their self-assembly and optimize their performance as smart nanocarriers. Multi-scale modeling and simulations provide a valuable ally to experiment by mapping the potential energy landscape of self-assembly, translocation, and delivery of smart drug-loaded NPs. Here, we highlight key recent advances to illustrate the concepts, methods, and applications of smart polymer-based NP drug delivery. We summarize the key design principles emerging for advanced multifunctional polymer topologies, illustrating how the unusual architecture and chemistry of dendritic polymers, self-assembling polyelectrolytes and cyclic polymers can provide exceptional drug delivery platforms. We provide a roadmap outlining the opportunities and challenges for the effective use of predictive multiscale molecular modeling techniques to accelerate the development of smart polymer-based drug delivery systems.

Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems: investigations using a novel fungicide

Soft Matter ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 715-726 ◽  
Author(s):  
Katrin Knop ◽  
Georges M. Pavlov ◽  
Tobias Rudolph ◽  
Karin Martin ◽  
David Pretzel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery Systems ◽  
Delivery Systems

scholarly journals Latest Advances in the Development of Eukaryotic Vaults as Targeted Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 300 ◽  
Author(s):  
Amanda Muñoz-Juan ◽  
Aida Carreño ◽  
Rosa Mendoza ◽  
José L. Corchero
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Cell Factories ◽  
Self Assembling ◽  
C Terminus ◽  
Cargo Protein ◽  
Almost All ◽  
Smart Drug ◽  
Smart Drug Delivery

The use of smart drug delivery systems (DDSs) is one of the most promising approaches to overcome some of the drawbacks of drug-based therapies, such as improper biodistribution and lack of specific targeting. Some of the most attractive candidates as DDSs are naturally occurring, self-assembling protein nanoparticles, such as viruses, virus-like particles, ferritin cages, bacterial microcompartments, or eukaryotic vaults. Vaults are large ribonucleoprotein nanoparticles present in almost all eukaryotic cells. Expression in different cell factories of recombinant versions of the “major vault protein” (MVP) results in the production of recombinant vaults indistinguishable from native counterparts. Such recombinant vaults can encapsulate virtually any cargo protein, and they can be specifically targeted by engineering the C-terminus of MVP monomer. These properties, together with nanometric size, a lumen large enough to accommodate cargo molecules, biodegradability, biocompatibility and no immunogenicity, has raised the interest in vaults as smart DDSs. In this work we provide an overview of eukaryotic vaults as a new, self-assembling protein-based DDS, focusing in the latest advances in the production and purification of this platform, its application in nanomedicine, and the current preclinical and clinical assays going on based on this nanovehicle.

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