scholarly journals Review of Terahertz Pulsed Imaging for Pharmaceutical Film Coating Analysis

Sensors ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 1441 ◽  
Author(s):  
Décio Alves-Lima ◽  
Jun Song ◽  
Xiaoran Li ◽  
Alessia Portieri ◽  
Yaochun Shen ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Film Coating ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Film Coatings ◽  
Topical Review ◽  
Terahertz Pulsed Imaging ◽  
Look Back ◽  
Non Destructive

Terahertz pulsed imaging (TPI) was introduced approximately fifteen years ago and has attracted a lot of interest in the pharmaceutical industry as a fast, non-destructive modality for quantifying film coatings on pharmaceutical dosage forms. In this topical review, we look back at the use of TPI for analysing pharmaceutical film coatings, highlighting the main contributions made and outlining the key challenges ahead.

scholarly journals A Review of the Applications of OCT for Analysing Pharmaceutical Film Coatings

2018 ◽  
Vol 8 (12) ◽  
pp. 2700 ◽  
Author(s):  
Hungyen Lin ◽  
Zijian Zhang ◽  
Daniel Markl ◽  
J. Zeitler ◽  
Yaochun Shen
Keyword(s):  
Thin Film ◽  
Optical Coherence Tomography ◽  
Manufacturing Industry ◽  
Dosage Forms ◽  
Pharmaceutical Manufacturing ◽  
Pharmaceutical Dosage Forms ◽  
Film Coatings ◽  
Thin Film Coatings ◽  
Topical Review ◽  
Non Destructive

Optical coherence tomography (OCT) has recently attracted a lot of interest in the pharmaceutical manufacturing industry as a fast, contactless and non-destructive modality for quantifying thin film coatings on pharmaceutical dosage forms, which cannot be resolved easily with other techniques. In this topical review, we present an overview of the research that has been performed to date, highlighting key differences between systems and outlining major challenges ahead.

Film coatings in the development of dosage forms

2020 ◽  
pp. 49-61
Author(s):  
V.N. Shestakov ◽  
S.V. Polyakov ◽  
L.V. Persanova ◽  
T. Yu. Andreevicheva ◽  
M.A. Veretennikova ◽  
...  
Keyword(s):  
Film Coating ◽  
Dosage Forms ◽  
Film Coatings

The article provides information about polymers and excipients used for film coating. The main manufacturers, groups of substances used in the compositions, as well as the complexity of the technology and possible defects in the application of coatings, are indicated.

scholarly journals Solventless coating for Tablets: An alternative to conventional coating technique

2014 ◽  
Vol 2 (02) ◽  
pp. 108-114
Author(s):  
Manish Jaimini ◽  
Arpit Jain ◽  
Sanjay K. Sharma ◽  
Shailender Mohan
Keyword(s):  
Spray Coating ◽  
Film Coating ◽  
Powder Coating ◽  
Dosage Forms ◽  
Taste Masking ◽  
Temperature Sensitive ◽  
Solvent Exposure ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Residual Solvent

There are many ways to coat tablets. Coatings are a very important part in the formulation of pharmaceutical dosage form to achieve excellent formulation quality (e.g., color, texture, mouth feel, and taste masking), physical and chemical protection for the drugs in the dosage forms, and modification of drug release characteristics. Most film coatings are applied as aqueous or organic-based polymer solutions. Such film coating brings their own disadvantages. Solventless coatings are alternative technique of coating. Solventless coating technologies can overcome many of the disadvantages associated with the use of solvents (e.g., solvent exposure, solvent disposal, and residual solvent in product) in pharmaceutical coating. Solventless processing reduces the overall cost by eliminating the tedious and expensive processes of solvent disposal/treatment. In addition, it can significantly reduce the processing time due to reduction of step of drying/evaporation. These environment-friendly processes are performed without any heat in most cases (except hot-melt coating) and thus can provide an alternative technology to coat temperature-sensitive drugs. This review includes various solventless coating methods like magnetic assisted impaction coating , hotmelt coating, supercritical fluid spray coating, electrostatic coating, dry powder coating, and photocurable coating that can be used to coat the pharmaceutical dosage forms.

Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

2012 ◽  
Vol 4 (4) ◽  
pp. 1563-1568
Author(s):  
Sagar Suman Panda ◽  
Ravi Kumar B V V ◽  
D Patanaik
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Dosage Form ◽  
Dosage Forms ◽  
Alendronate Sodium ◽  
Colored Complex ◽  
Pharmaceutical Dosage Forms ◽  
Recovery Study ◽  
Assay Conditions

A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recovery study were found to be in the range of 99.37%-100.46%. The R.S.D. values for intraday and inter-day precision were found to be 0.48 and 0.62, respectively. The optimized assay conditions were applied successfully for determination of ALS in pharmaceutical dosage forms. No interference was observed from the excipients present in the dosage form. The method is statistically validated as per the ICH requirements.  

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