scholarly journals Reactive UAV Fleet’s Mission Planning in Highly Dynamic and Unpredictable Environments

2021 ◽  
Vol 13 (9) ◽  
pp. 5228
Author(s):  
Grzegorz Radzki ◽  
Izabela Nielsen ◽  
Paulina Golińska-Dawson ◽  
Grzegorz Bocewicz ◽  
Zbigniew Banaszak
Keyword(s):  
Time Horizon ◽  
Urban Freight ◽  
Online Planning ◽  
Novel Approach ◽  
Last Mile ◽  
Reactive Planning ◽  
Weather Changes ◽  
Unpredictable Environment ◽  
Interesting Alternative

Unmanned aerial vehicles (UAVs) create an interesting alternative for establishing more sustainable urban freight deliveries. The substitution of traditional trucks in the last-mile distribution by a UAV fleet can contribute to urban sustainability by reducing air pollution and increasing urban freight efficiency. This paper presents a novel approach to the joint proactive and reactive planning of deliveries by a UAV fleet. We develop a receding horizon-based approach to reactive, online planning for the UAV fleet’s mission. We considered the delivery of goods to spatially dispersed customers over an assumed time horizon. Forecasted weather changes affect the energy consumption of UAVs and limit their range. Therefore, consideration should be given to plans for follow-up tasks, previously unmet needs, and predictions of disturbances over a moving time horizon. We propose a set of reaction rules that can be encountered during delivery in a highly dynamic and unpredictable environment. We implement a constraint programming paradigm, which is well suited to cope with the nonlinearity of the system’s characteristics. The proposed approach to online reactive UAV routing is evaluated in several instances. The computational experiments have shown that the developed model is capable of providing feasible plans for a UAV fleet’s mission that are robust to changes in weather and customer’s orders.

Image-guided translumbar type II endoleak repair: A novel approach

2020 ◽  
Vol 4 ◽  
pp. 9
Author(s):  
Salman Mirza ◽  
Shahnawaz Ansari
Keyword(s):  
Mesenteric Artery ◽  
Inferior Mesenteric Artery ◽  
Endovascular Aneurysm Repair ◽  
Type Ii ◽  
Type Ii Endoleak ◽  
Image Guided ◽  
Novel Approach ◽  
Abdominal Aortic ◽  
Aneurysm Repair

We present a case of a 72-year-old male with an abdominal aortic aneurysm status post-endovascular aneurysm repair (EVAR). Follow-up imaging demonstrated an enlarging type II endoleak and attempts at transarterial coil embolization of the inferior mesenteric artery were unsuccessful. The patient underwent image-guided percutaneous translumbar type II endoleak repair using XperGuide (Philips, Andover, MA USA).

scholarly journals Defining key questions for clinical practice guidelines: a novel approach for developing clinically relevant questions

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Samantha Chakraborty ◽  
Bianca Brijnath ◽  
Jacinta Dermentzis ◽  
Danielle Mazza
Keyword(s):  
Qualitative Research ◽  
Clinical Practice ◽  
Clinical Practice Guidelines ◽  
Practice Guidelines ◽  
Best Practice ◽  
International Guideline ◽  
Novel Approach ◽  
Clinical Questions ◽  
Key Questions

Abstract Background There is no standardised protocol for developing clinically relevant guideline questions. We aimed to create such a protocol and to apply it to developing a new guideline. Methods We reviewed international guideline manuals and, through consensus, combined steps for developing clinical questions to produce a best-practice protocol that incorporated qualitative research. The protocol was applied to develop clinical questions for a guideline for general practitioners. Results A best-practice protocol incorporating qualitative research was created. Using the protocol, we developed 10 clinical questions that spanned diagnosis, management and follow-up. Conclusions Guideline developers can apply this protocol to develop clinically relevant guideline questions.

scholarly journals CVDentus bur for epithelial abrasion in the treatment of melanin pigmentation: case report

RSBO ◽  
2018 ◽  
Vol 1 (3) ◽  
pp. 186
Author(s):  
Katiane Vieira Menezes Leite ◽  
Patrícia Oliveira de Souza ◽  
Jussania Fonseca da Paz ◽  
Ana Beatriz Franco Fernandes ◽  
Leonardo Fernandes da Cunha ◽  
...  
Keyword(s):  
Case Report ◽  
Low Cost ◽  
Melanin Pigmentation ◽  
Alternative Approach ◽  
Safe Technique ◽  
Dark Color ◽  
One Year ◽  
Fast Procedure ◽  
Interesting Alternative

Introduction: The gingival melanin hyperpigmentation (GMH) is resulted from an abnormal deposition of melanin, but it is not a pathology. However, GMH is an esthetic problem for some people. Some alternatives of treatment for this situation exist. The epithelial abrasion has been an interesting alternative because it has a satisfactory esthetic outcome, is a fast procedure, of easy execution, and low cost. Recently, tips adapted in ultrasound (CVDentus) can bean alternative approach. Objective: To report a clinical case of GMH treated by the technique of the epithelial abrasion with association of instrument adapted in ultrasound. Case report: Patient aged 28 years, melanoderm, sought treatment due to esthetic dissatisfaction because of intense dark color in the maxillary gingiva. The GMH removal was proposed through the technique of the epithelialabrasion CVD bur. Conclusion: The technique of epithelial abrasion using CVD bur was effective in removing GMH at one-year follow-up showing to be easy and safe technique.

scholarly journals Brief Intermittent Neuroleptic Prophylaxis for Selected Schizophrenic Out-patients

1989 ◽  
Vol 155 (05) ◽  
pp. 702-706 ◽  
Author(s):  
H. A. McClelland ◽  
G. Harrison ◽  
S. D. Soni
Keyword(s):  
Psychotic Symptoms ◽  
Intermittent Treatment ◽  
Double Blind ◽  
Prodromal Symptoms ◽  
Novel Approach ◽  
Depot Neuroleptic ◽  
One Year ◽  
Depot Injections ◽  
To Receive

“A study was conducted to investigate a novel approach to the prophylaxis of schizophrenic relapse. The treatment strategy comprised brief intermittent courses of neuroleptic agents begun as soon as non-psychotic symptoms believed to be early signs of relapse appeared. Fifty four stable, remitted outpatients meeting the American Psychiatric Association's DSM–III criteria for schizophrenia were randomised double blind to receive brief intermittent treatment with either active or placebo depot neuroleptic injections. Only three patients given placebo injections and two controls were admitted to hospital during one year of follow up. Eight (30%) of the patients given placebo injections and only 2 (7%) of the controls, however, had a recurrence of schizophrenic symptoms. Patients given placebo injections experienced fewer extrapyramidal side effects and showed a trend towards a reduction in tardive dyskinesia. Dysphoric and neurotic symptoms were identified before eight out of 11 relapses, and these symptoms were more frequent in patients given placebo depot injections. These results suggest a viable but not necessarily better alternative to continuous oral or depot treatment for less ill, chronic, stabilised schizophrenics based on the early treatment of putative prodromal symptoms of relapse.”

scholarly journals Safety and Efficacy of Prolonged Use of Dalbavancin in Bone and Joint Infections

2019 ◽  
Vol 63 (5) ◽  
Author(s):  
L. Morata ◽  
J. Cobo ◽  
M. Fernández-Sampedro ◽  
P. Guisado Vasco ◽  
E. Ruano ◽  
...  
Keyword(s):  
Adverse Events ◽  
Orthopedic Implant ◽  
Cure Rate ◽  
High Concentration ◽  
Osteoarticular Infection ◽  
Content Type ◽  
Joint Infections ◽  
Favorable Safety ◽  
Interesting Alternative

ABSTRACT Dalbavancin is a lipoglycopeptide with potent activity against Gram-positive microorganisms, a long half-life, a favorable safety profile, and a high concentration in bone, which makes it an interesting alternative for treatment of osteoarticular infections. We performed a multicentric retrospective study of all patients with an osteoarticular infection (septic arthritis, spondylodiscitis, osteomyelitis, or orthopedic implant-related infection) treated with at least one dose of dalbavancin between 2016 and 2017 in 30 institutions in Spain. In order to evaluate the response, patients with or without an orthopedic implant were separated. A total of 64 patients were included. Staphylococcus epidermidis and Staphylococcus aureus were the most frequent microorganisms. The reasons for switching to dalbavancin were simplification (53.1%), adverse events (25%), or failure (21.9%). There were 7 adverse events, and no patient had to discontinue dalbavancin. In 45 cases, infection was related to an orthopedic implant. The implant material was retained in 23 cases, including that in 15 (65.2%) patients that were classified as cured and 8 (34.8%) that presented improvement. In 21 cases, the implants were removed, including those in 16 (76.2%) cases that were considered successes, 4 (19%) cases were considered improved, and 1 (4.8%) case that was considered a failure. Among the 19 cases without implants, 14 (73.7%) were considered cured, 3 (15.8%) were considered improved, and 2 (10.5%) were considered failures. The results show that dalbavancin is a well-tolerated antibiotic, even when >2 doses are administered, and is associated with a high cure rate. These are preliminary data with a short follow-up; therefore, it is necessary to gain more experience and, in the future, to establish the most appropriate dose and frequency.

SHARED CARE: A NOVEL APPROACH TO LEFT VENTRICULAR ASSIST DEVICE (LVAD) IMPLANT FOLLOW UP

2020 ◽  
Vol 75 (11) ◽  
pp. 774
Author(s):  
Ganesh Gajanan ◽  
Kulpreet Barn ◽  
Jerome Thomas ◽  
Mauricio Garrido ◽  
Rohinton Morris ◽  
...  
Keyword(s):  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Shared Care ◽  
Assist Device ◽  
Ventricular Assist ◽  
Novel Approach ◽  
Left Ventricular Assist

scholarly journals Effects of apixaban compared with warfarin as gain in event-free time – a novel assessment of the results of the ARISTOTLE trial

2019 ◽  
Vol 27 (12) ◽  
pp. 1311-1319 ◽  
Author(s):  
Erik Berglund ◽  
Lars Wallentin ◽  
Jonas Oldgren ◽  
Henrik Renlund ◽  
John H Alexander ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Intracranial Bleeding ◽  
Free Time ◽  
Systemic Embolism ◽  
Bleeding Events ◽  
Double Blind ◽  
Warfarin Group ◽  
Novel Approach ◽  
Atrial Fibrillation Trial

Background A novel approach to determine the effect of a treatment is to calculate the delay of event, which estimates the gain of event-free time. The aim of this study was to estimate gains in event-free time for stroke or systemic embolism, death, bleeding events, and the composite of these events, in patients with atrial fibrillation randomized to either warfarin or apixaban in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial (ARISTOTLE). Design The ARISTOTLE study was a randomized double-blind trial comparing apixaban with warfarin. Methods Laplace regression was used to estimate the delay in time to the outcomes between the apixaban and the warfarin group in 6, 12, 18 and 22 months of follow-up. Results The gain in event-free time for apixaban versus warfarin was 181 (95% confidence interval 76 to 287) days for stroke or systemic embolism and 55 (–4 to 114) days for death after 22 months of follow-up. The corresponding gains in event-free times for major and intracranial bleeding were 206 (130 to 281) and 392 (249 to 535) days, respectively. The overall gain for the composite of all these events was a gain of 116 (60 to 171) days. Conclusions In patients with atrial fibrillation, 22 months of treatment with apixaban, as compared with warfarin, provided gains of approximately 6 months in event-free time for stroke or systemic embolism, 7 months for major bleeding and 13 months for intracranial bleeding.

A Novel Approach for Repairing Superior Mesenteric Artery Injury During Left Nephrectomy—6-year Follow-up

Urology ◽  
2020 ◽  
Vol 144 ◽  
pp. 241-244
Author(s):  
Liyuan Zhang ◽  
Xiaokang Zhang ◽  
Pengcheng Chang ◽  
Jie Yang ◽  
Duo Zheng ◽  
...  
Keyword(s):  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Artery Injury ◽  
Novel Approach

Pars plana Ex-Press mini shunt for management of persistent glaucoma in vitrectomized eyes: A novel technique

2020 ◽  
Vol 30 (5) ◽  
pp. 1179-1184 ◽  
Author(s):  
Abdussalam Abdullatif ◽  
Heba El-Saied
Keyword(s):  
Intraocular Pressure ◽  
Silicone Oil ◽  
Case Series ◽  
Ultrasound Biomicroscopy ◽  
Secondary Glaucoma ◽  
Antiglaucoma Medication ◽  
Novel Approach ◽  
Pars Plana ◽  
Secondary Refractory

Purpose: To evaluate the safety and efficacy of a novel approach to implant Ex-Press mini shunt via the pars plana under a scleral flap in pseudophakic or aphakic, vitrectomized patients with secondary refractory glaucoma. Methods: A prospective interventional case series of three patients with secondary glaucoma after pars plana vitrectomy. Intraocular pressure was not controlled by silicone oil removal, if the patient was siliconized, nor the maximum medical treatment. Ex-Press mini shunt via the pars plana was implanted. We evaluated the control of intraocular pressure and the development of intraoperative and postoperative complications. Results: During 1-year follow-up, control of intraocular pressure was achieved; 14, 15, and 15 mmHg at the 3 months, and 15, 15, and 16 mmHg at the 6 months in our three cases without antiglaucoma treatment and 16, 16, and 18 with single antiglaucoma medication at 1 year. Blebs were posterior and diffuse. No complications were encountered intraoperatively or postoperatively. Ultrasound biomicroscopy showed suprachoroidal posterior lake of fluid as an additional filtration route without any choroidal or retinal complication. Conclusion: Implantation of Ex-Press mini shunt via the pars plana in aphakic or pseudophakic, vitrectomized eyes is a promising, safe, and effective technique in patients with secondary glaucoma.

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