Widespread Distribution and Adaptive Degradation of Microcystin Degrader (mlr-Genotype) in Lake Taihu, China

Microbial degradation is an important route for removing environmental microcystins (MCs). Here, we investigated the ecological distribution of microcystin degraders (mlr-genotype), and the relationship between the substrate specificity of the microcystin degrader and the profile of microcystin congener production in the habitat. We showed that microcystin degraders were widely distributed and closely associated with Microcystis abundance in Lake Taihu, China. We characterized an indigenous degrader, Sphingopyxis N5 in the northern Lake Taihu, and it metabolized six microcystin congeners in increasing order (RR > LR > YR > LA > LF and LW). Such a substrate-specificity pattern was congruent to the order of the dominance levels of these congeners in northern Lake Taihu. Furthermore, a meta-analysis on global microcystin degraders revealed that the substrate-specificity patterns varied geographically, but generally matched the profiles of microcystin congener production in the degrader habitats, and the indigenous degrader typically metabolized well the dominant MC congeners, but not the rare congeners in the habitat. This highlighted the phenotypic congruence between microcystin production and degradation in natural environments. We theorize that such congruence resulted from the metabolic adaptation of the indigenous degrader to the local microcystin congeners. Under the nutrient microcystin selection, the degraders might have evolved to better exploit the locally dominant congeners. This study provided the novel insight into the ecological distribution and adaptive degradation of microcystin degraders.

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Multi-omic meta-analysis of transcriptomes and the bibliome uncovers GPR146 as the novel hypoxia-inducible gene

10.1101/2021.03.29.433661 ◽

2021 ◽

Author(s):

Yoko Ono ◽

Hidemasa Bono

Keyword(s):

Meta Analysis ◽

Hypoxia Inducible Factor ◽

Enrichment Analysis ◽

The Novel ◽

Hypoxia Inducible Factor 1 ◽

Response System ◽

The Relationship ◽

G Protein Coupled ◽

Inducible Gene ◽

Sufficient Oxygen

Hypoxia is a condition in which cells, tissues, or organisms are deprived of sufficient oxygen supply. Aerobic organisms have the hypoxic response system, represented by hypoxia-inducible factor 1-α (HIF1A), to avoid this condition. Because of publication bias, the genes other than well-known signature hypoxia-stimulating genes may not be focused. Therefore, in this study, we performed meta-analysis to identify novel hypoxia-responsive genes. We searched publicly available transcriptome databases to obtain hypoxia-related experimental data, retrieved the metadata, and manually curated it. We selected the genes that are differentially expressed by hypoxic stimulation, and evaluated their relevance in hypoxia by performing enrichment analyses. We then calculated the number of reports and similarity coefficient of each gene for HIF1A (surrogate for hypoxia) using gene2pubmed that provides information about the relationship between gene and publication. Enrichment analysis confirmed that the selected genes were related to hypoxic stimulation, as expected. We then performed gene2pubmed analysis to investigate the genes that had not been fully studied under hypoxia. In this data-driven study, we report that the G protein-coupled receptor 146 gene is upregulated by hypoxic stimulation.

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The role of developmental change and linguistic experience in the mutual exclusivity effect

10.31234/osf.io/wsx3a ◽

2019 ◽

Cited By ~ 3

Author(s):

Molly Lewis ◽

Veronica Cristiano ◽

Brenden M. Lake ◽

Tammy Kwan ◽

Michael C. Frank

Keyword(s):

Empirical Study ◽

Developmental Change ◽

Meta Analysis ◽

Quantitative Description ◽

The Novel ◽

Mutual Exclusivity ◽

Word Meanings ◽

Linguistic Experience ◽

The Relationship

Given a novel word and a familiar and a novel referent, children have a bias to assume the novel word refers to the novel referent. This bias -- often referred to as "Mutual Exclusivity'' (ME) -- is thought to be a potentially powerful route through which children might learn new word meanings, and, consequently, has been the focus of a large amount of empirical study and theorizing. Here, we focus on two aspects of the bias that have received relatively little attention in the literature: Development and experience. A successful theory of ME will need to provide an account for why the strength of the effect changes with the age of the child. We provide a quantitative description of the change in the strength of the bias across development, and investigate the role that linguistic experience plays in this developmental change. We first summarize the current body of empirical findings via a meta-analysis, and then present two experiments that examine the relationship between a child's amount of linguistic experience and the strength of the ME bias. We conclude that the strength of the bias varies dramatically across development and that linguistic experience is likely one causal factor contributing to this change. In the General Discussion, we describe how existing theories of ME can account for our findings, and highlight the value of computational modeling for future theorizing.

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Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽

10.1024/0301-1526/a000891 ◽

2020 ◽

pp. 1-6

Author(s):

Hanji Zhang ◽

Dexin Yin ◽

Yue Zhao ◽

Yezhou Li ◽

Dejiang Yao ◽

...

Keyword(s):

Large Scale ◽

Meta Analysis ◽

Single Species ◽

Total Plasma ◽

Control Groups ◽

Randomized Controlled ◽

Randomized Controlled Studies ◽

The Difference ◽

The Relationship ◽

Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

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A Meta-Analysis of Interviews and Cognitive Ability

Journal of Personnel Psychology ◽

10.1027/1866-5888/a000091 ◽

2013 ◽

Vol 12 (4) ◽

pp. 157-169 ◽

Cited By ~ 7

Author(s):

Philip L. Roth ◽

Allen I. Huffcutt

Keyword(s):

Cognitive Ability ◽

Meta Analysis ◽

Incremental Validity ◽

Employment Interviews ◽

Moderator Analysis ◽

The Future ◽

Research Questions ◽

Meta Analyses ◽

The Relationship

The topic of what interviews measure has received a great deal of attention over the years. One line of research has investigated the relationship between interviews and the construct of cognitive ability. A previous meta-analysis reported an overall corrected correlation of .40 ( Huffcutt, Roth, & McDaniel, 1996 ). A more recent meta-analysis reported a noticeably lower corrected correlation of .27 ( Berry, Sackett, & Landers, 2007 ). After reviewing both meta-analyses, it appears that the two studies posed different research questions. Further, there were a number of coding judgments in Berry et al. that merit review, and there was no moderator analysis for educational versus employment interviews. As a result, we reanalyzed the work by Berry et al. and found a corrected correlation of .42 for employment interviews (.15 higher than Berry et al., a 56% increase). Further, educational interviews were associated with a corrected correlation of .21, supporting their influence as a moderator. We suggest a better estimate of the correlation between employment interviews and cognitive ability is .42, and this takes us “back to the future” in that the better overall estimate of the employment interviews – cognitive ability relationship is roughly .40. This difference has implications for what is being measured by interviews and their incremental validity.

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The Relationship Between Immorality and Cleansing

Social Psychology ◽

10.1027/1864-9335/a000349 ◽

2018 ◽

Vol 49 (5) ◽

pp. 303-309 ◽

Cited By ~ 3

Author(s):

Jedidiah Siev ◽

Shelby E. Zuckerman ◽

Joseph J. Siev

Keyword(s):

Effect Size ◽

Meta Analysis ◽

Weighted Mean ◽

The Relationship

Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to respond to moral threat with physical cleansing is known as the Macbeth Effect. Several subsequent efforts, however, did not replicate this relationship. The present manuscript reports the results of a meta-analysis of 15 studies testing this relationship. The weighted mean effect size was small across all studies (g = 0.17, 95% CI [0.04, 0.31]), and nonsignificant across studies conducted in independent laboratories (g = 0.07, 95% CI [−0.04, 0.19]). We conclude that there is little evidence for an overall Macbeth Effect; however, there may be a Macbeth Effect under certain conditions.

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