scholarly journals Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species

Viruses ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1108 ◽  
Author(s):  
Joachim Denner ◽  
Tarin M. Bigley ◽  
Tuan L. Phan ◽  
Cosima Zimmermann ◽  
Xiaofeng Zhou ◽  
...  

Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they can cause severe diseases including encephalitis in immunocompromised transplant and AIDS patients and febrile seizures in infants. They have been linked to a number of neurological diseases in the immunocompetent including multiple sclerosis (MS) and Alzheimer’s. However, to prove the causality in the latter disease associations is challenging due to the high prevalence of these viruses in the human population. PCMV/PRV has attracted attention because it may be transmitted and pose a risk in xenotransplantation, e.g., the transplantation of pig organs into humans. Most importantly, all roseoloviruses are immunosuppressive, the humoral and cellular immune responses against these viruses are not well studied and vaccines as well as effective antivirals are not available.

1999 ◽  
Vol 180 (5) ◽  
pp. 1682-1685 ◽  
Author(s):  
Howard D. Strickler ◽  
James J. Goedert ◽  
F. R. Bethke ◽  
C. M. Trubey ◽  
Thomas R. O'Brien ◽  
...  

2015 ◽  
Vol 177 (1-2) ◽  
pp. 95-105 ◽  
Author(s):  
P.J. Sánchez-Cordón ◽  
A.C. Pérez de Diego ◽  
J.C. Gómez-Villamandos ◽  
J.M. Sánchez-Vizcaíno ◽  
F.J. Pleguezuelos ◽  
...  

2014 ◽  
Vol 155 (1) ◽  
pp. 91-107 ◽  
Author(s):  
Antonio Valentin ◽  
Katherine McKinnon ◽  
Jinyao Li ◽  
Margherita Rosati ◽  
Viraj Kulkarni ◽  
...  

1999 ◽  
Vol 73 (7) ◽  
pp. 6136-6140 ◽  
Author(s):  
Mohamed Osman ◽  
Toru Kubo ◽  
Jasjit Gill ◽  
Frank Neipel ◽  
Marion Becker ◽  
...  

ABSTRACT Human herpesvirus 8 (HHV-8) (or Kaposi’s sarcoma-associated herpesvirus) is implicated in the etiopathogenesis of Kaposi’s sarcoma (KS) and certain lymphoproliferations. The introduction of more effective therapies to treat human immunodeficiency virus infection has led to a decline in the incidence of KS and also in the resolution of KS in those already affected. This suggests that cellular immune responses including cytotoxic T lymphocytes (CTLs) could play a vital role in the control of HHV-8 infection and in KS pathogenesis. Here we elucidate HLA class I-restricted, HHV-8-specific cellular immune responses that could be important in the control of HHV-8 infection and subsequent tumor development. We show the presence of CTLs against HHV-8 latent (K12), lytic (K8.1), and highly variable (K1) proteins in infected individuals.


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