Benign Fasciculation Syndrome and Migraine Aura without Headache: Possible Rare Side Effects of the BNT162b2 mRNA Vaccine? A Case Report and a Potential Hypothesis

The BNT162b2 (Pfizer BioNTech) mRNA vaccine is an effective vaccine against COVID-19 infection. Here, we report an adverse event following immunization (AEFI) in a 48-year-old female patient who presented with fasciculations, migraine auras without headaches and in an increased discomfort of previously present palpitations, as well as excitation and insomnia. Her fasciculations were intermittently present until the time this paper was written, starting from the 6th day post-vaccination; they changed localization and frequency, but most commonly they were generalized, affecting almost all muscle groups. The patient also suffered from two incidents of migraine auras with visual kaleidoscope-like phenomena without headaches a few months after the vaccination. These symptoms were considered to be AEFI and no causal relation with the vaccine could be proven.

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Symptoms and Side Effects of the ChAdOx1 nCoV-19 vaccine (AZD1222) among healthcare workers

10.53350/pjmhs2115123202 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3202-3204

Author(s):

Dawood Javed ◽

Yazeed Hadi Alharbi ◽

Abdullah Javed ◽

Javed Iqbal

Keyword(s):

Side Effects ◽

Sampling Strategy ◽

Effective Vaccine ◽

Healthy Population ◽

Snowball Sampling ◽

Web Based ◽

Post Vaccination ◽

Local Methods ◽

Novel Coronavirus ◽

A Prospective Study

Aim: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a novel coronavirus which has infected millions of people across the globe in the form of a deadly pandemic. Safe and efficacious vaccines are needed urgently to prevent disease in the healthy population or at least decrease the intensity of illness post vaccination. Aim: To assess the post vaccination side effects among groups of individuals so that an effective vaccine can be proposed according to the individuals and thus avoiding reactogenicity, both systemic and local. Methods: A prospective study was conducted with the help of a web-based questionnaire (among health care workers) which used snowball sampling strategy and assigned persons aged ≥25-65 years, who received an intramuscular injection of the vaccine manufactured by Oxford-AstraZeneca. Safety and side effects were observed over a period of 15-20 days post vaccination to obtain results. Results: A total of 564 participants took part in the survey who received the vaccine via intramuscular route. Both systemic and local reactogenicity were recorded. Of the respondents, 280 (49.6%) people reported fever, 322 (57.18%) had pain, 89 (15.77%) had swelling and 53 (9.3%) had redness at the injection site. Total of 368 (65.2%) individuals suffered from body aches of whom 324 (57.4%) also reported headaches. Conclusion: Assessing the post vaccination symptoms, side effects and complications of AstraZeneca among different individuals helped in providing crucial and important information regarding the efficacy, safety and nature of the vaccine. Keywords: Covid-19, pandemic, vaccines, reactogenicity

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Kikuchi–Fujimoto Disease Post COVID-19 Vaccination: Case Report and Review of Literature

Vaccines ◽

10.3390/vaccines9111251 ◽

2021 ◽

Vol 9 (11) ◽

pp. 1251

Author(s):

Hui Min Tan ◽

Susan Swee-Shan Hue ◽

Aileen Wee ◽

Kay Choong See

Keyword(s):

Case Report ◽

Side Effects ◽

Literature Review ◽

Side Effect ◽

Clinical Course ◽

Rapid Development ◽

Asian Population ◽

Common Side Effect ◽

Review Of Literature ◽

Post Vaccination

With the rapid development of various coronavirus disease 2019 (COVID-19) vaccines in a bid to counter and contain the COVID-19 pandemic, unusual and uncommon side effects of COVID-19 vaccination have been increasingly reported in the literature. Ipsilateral lymphadenopathy is a fairly common side effect of vaccination of any kind, with its etiology most commonly related to reactive lymphadenopathy. However, Kikuchi–Fujimoto Disease (KFD) or necrotizing histiocytic lymphadenitis is rarely observed post-vaccination, with only one other case of KFD post COVID-19 vaccination reported to date. We report two more cases of KFD post COVID-19 vaccination in the Asian population, highlighting the clinical course and salient clinical, radiological and histologic findings. In addition, we provide a literature review of the existing cases of lymphadenopathy post COVID-19 vaccination with cytologic and/or histologic correlation.

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Countering Hesitancy and Misinformation on Side Effects to Complete the Course of COVID Vaccination

Journal of Patient Experience ◽

10.1177/23743735211067313 ◽

2021 ◽

Vol 8 ◽

pp. 237437352110673

Author(s):

Nabarun Dasgupta

Keyword(s):

Primary Care ◽

Decision Making ◽

Adverse Event ◽

Side Effects ◽

Family Medicine ◽

Decision Making Process ◽

Event Data ◽

Post Vaccination ◽

Adverse Event Data ◽

To Receive

It has been well-documented that concerns about side effects prevent many from soliciting immunization. And family medicine providers play a key role in addressing concerns about COVID vaccines. However, there are few documented examples of the decision-making process regarding second shots after the emergence of a concerning and previously unknown side effect. Therefore, we present a case where a primary care provider and patient worked together to analyze real-time adverse event data on post-vaccination shingles to decide whether to receive the second dose.

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Febrile pleuropericarditis, a potentially life-threatening adverse event of balsalazide – case report and literature review of the side effects of 5-aminosalicylates

Expert Review of Clinical Immunology ◽

10.1586/1744666x.2014.902313 ◽

2014 ◽

Vol 10 (5) ◽

pp. 667-675 ◽

Cited By ~ 3

Author(s):

Roxana M Coman ◽

Sarah C Glover ◽

Altin Gjymishka

Keyword(s):

Adverse Event ◽

Case Report ◽

Side Effects ◽

Literature Review ◽

Life Threatening

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Suspected immune mediated response to COVID-19 vaccine: two individual case reports

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20212385 ◽

2021 ◽

Vol 10 (7) ◽

pp. 851

Author(s):

Sagar R. Bhimani ◽

Sapna D. Gupta ◽

Kamlesh P. Patel ◽

Supriya D. Malhotra

Keyword(s):

Adverse Event ◽

Causal Relation ◽

Case Reports ◽

Vaccine Safety ◽

Individual Case ◽

Adverse Event Following Immunization ◽

First Case ◽

Immune Mediated ◽

Potential Risks

SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), has spread rapidly around the world. Researchers have been working round the clock to develop effective vaccines, which people started receiving in December 2020. Therefore, careful follow-up and surveillance studies for continued vaccine safety monitoring will be needed to ascertain the potential risks of such adverse events or disease. Here, we present two individual cases of pancreatitis and typhilitis following COVID 19 vaccination. In the first case of a 38 years old male patient developed pancreatitis after 4 days of COVID 19 vaccination and in second case, of a 60 years old female patient developing typhilitis after just one day after vaccination. All possible causes of this occurrence were ruled out. Two main factors suggest a possible link to the vaccine, the chronology of the events and the incongruent immune response to the vaccine component. It is not possible to establish a direct causal relation between vaccination and adverse event following immunization; however, this report can be used to alert practitioners to this possibility of adverse event following immunization after COVID-19 vaccine.

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Polymyalgia rheumatica as uncommon adverse event following immunization with COVID‐19 vaccine: A case report and review of literature

Aging Medicine ◽

10.1002/agm2.12171 ◽

2021 ◽

Author(s):

Ciro Manzo ◽

Maria Natale ◽

Alberto Castagna

Keyword(s):

Adverse Event ◽

Case Report ◽

Polymyalgia Rheumatica ◽

Review Of Literature ◽

Adverse Event Following Immunization

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Long-term side effects following pneumonectomy: A case report and review of the literature

10.1055/s-0039-1694143 ◽

2019 ◽

Author(s):

BA Högerle ◽

EL Bulut ◽

L Klotz ◽

F Eichhorn ◽

M Eichhorn ◽

...

Keyword(s):

Case Report ◽

Side Effects ◽

Review Of The Literature

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What the Cardiologist Needs to Consider in the Management of Oncologic Patients with STEMI-Like Syndrome; A Case Report and Literature Review

Pharmaceuticals ◽

10.3390/ph14060563 ◽

2021 ◽

Vol 14 (6) ◽

pp. 563

Author(s):

Aneta Aleksova ◽

Giulia Gagno ◽

Alessandro Pierri ◽

Carla Todaro ◽

Alessandra Lucia Fluca ◽

...

Keyword(s):

Myocardial Infarction ◽

Case Report ◽

Side Effects ◽

Single Agent ◽

St Segment Elevation ◽

Cardiac Catheterization Laboratory ◽

Cardiac Side Effects ◽

Coronary Syndrome ◽

St Segment ◽

Oncologic Patients

In pre-hospital care, an accurate and quick diagnosis of ST-segment elevation myocardial infarction (STEMI) is imperative to promptly kick-off the STEMI network with a direct transfer to the cardiac catheterization laboratory (cath lab) in order to reduce myocardial infarction size and mortality. Aa atherosclerotic plaque rupture is the main mechanism responsible for STEMI. However, in a small percentage of patients, emergency coronarography does not reveal any significant coronary stenosis. The fluoropyrimidine agents such as 5-Fluorouracil (5-FU) and capecitabine, widely used to treat gastrointestinal, breast, head and neck cancers, either as a single agent or in combination with other chemotherapies, can cause potentially lethal cardiac side effects. Here, we present the case of a patient with 5-FU cardiotoxicity resulting in an acute coronary syndrome (ACS) with recurrent episodes of chest pain and ST-segment elevation.. Our case report highlights the importance of widening the knowledge among cardiologists of the side effects of chemotherapeutic drugs, especially considering the rising number of cancer patients around the world and that fluoropyrimidines are the main treatment for many types of cancer, both in adjuvant and advanced settings.

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