Symptoms and Side Effects of the ChAdOx1 nCoV-19 vaccine (AZD1222) among healthcare workers

2021 ◽  
Vol 15 (12) ◽  
pp. 3202-3204
Author(s):  
Dawood Javed ◽  
Yazeed Hadi Alharbi ◽  
Abdullah Javed ◽  
Javed Iqbal
Keyword(s):  
Side Effects ◽  
Sampling Strategy ◽  
Effective Vaccine ◽  
Healthy Population ◽  
Snowball Sampling ◽  
Web Based ◽  
Post Vaccination ◽  
Local Methods ◽  
Novel Coronavirus ◽  
A Prospective Study

Aim: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is a novel coronavirus which has infected millions of people across the globe in the form of a deadly pandemic. Safe and efficacious vaccines are needed urgently to prevent disease in the healthy population or at least decrease the intensity of illness post vaccination. Aim: To assess the post vaccination side effects among groups of individuals so that an effective vaccine can be proposed according to the individuals and thus avoiding reactogenicity, both systemic and local. Methods: A prospective study was conducted with the help of a web-based questionnaire (among health care workers) which used snowball sampling strategy and assigned persons aged ≥25-65 years, who received an intramuscular injection of the vaccine manufactured by Oxford-AstraZeneca. Safety and side effects were observed over a period of 15-20 days post vaccination to obtain results. Results: A total of 564 participants took part in the survey who received the vaccine via intramuscular route. Both systemic and local reactogenicity were recorded. Of the respondents, 280 (49.6%) people reported fever, 322 (57.18%) had pain, 89 (15.77%) had swelling and 53 (9.3%) had redness at the injection site. Total of 368 (65.2%) individuals suffered from body aches of whom 324 (57.4%) also reported headaches. Conclusion: Assessing the post vaccination symptoms, side effects and complications of AstraZeneca among different individuals helped in providing crucial and important information regarding the efficacy, safety and nature of the vaccine. Keywords: Covid-19, pandemic, vaccines, reactogenicity

scholarly journals A snapshot of public knowledge of novel coronavirus disease 2019: a web-based national survey

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yu Liu ◽  
Dan Wang ◽  
Hao Xu ◽  
Ying Xiao ◽  
Cui Chen ◽  
...  
Keyword(s):  
Tertiary Education ◽  
Cross Sectional Study ◽  
Control Measures ◽  
Psychological State ◽  
Secondary Outcome ◽  
Public Knowledge ◽  
Snowball Sampling ◽  
Cross Sectional ◽  
Web Based ◽  
Novel Coronavirus

Abstract Background Although the number of existing cases of coronavirus disease 2019 (COVID-19) in China has been decreasing since late February 2020, the number of confirmed cases abroad is surging. Improving public knowledge of COVID-19 is critical to controlling the pandemic. This study aimed to determine China’s public knowledge of COVID-19 and the attitudes towards control measures. Methods A cross-sectional study was conducted over 48 h from 22:30 29 February 2020 to 22:30 2 March 2020 based on a self-administered web-based questionnaire. The survey was conducted on the WeChat network. Exponential non-discriminative snowball sampling was applied. The questionnaire was voluntarily completed by WeChat users. The questionnaire covered basic demographic information, public knowledge of the epidemiological and clinical characteristics of COVID-19, psychological state, and attitudes towards the overall control measures. The primary outcome was the China’s public knowledge of COVID-19 and the attitudes towards control measures and secondary outcome was the psychological state of the public during this pandemic. Results The study included 10,905 participants and 10,399 valid questionnaires were included for analysis. Participants with tertiary education, younger participants and healthcare workers had better overall knowledge than other participants (all P < 0.05). Approximately 91.9% of the participants believed in person-to-person transmission and 39.1% believed in animal-to-person transmission. No significant correlation between anxiety and the number of regional existing confirmed cases was found, while participants in Hubei were more anxious than those in other regions. In general, 74.1% of the participants acknowledged the effectiveness of the overall control measures, and the percentage of participants with agreement with the overall control measures was negatively correlated with the number of regional existing confirmed cases (r = − 0.492, P = 0.007). Conclusions In conclusion, the survey revealed that the Chinese public had overall good knowledge of COVID-19 except for those indeterminate knowledges. With dynamic changes in the global pandemic situation and more research, further studies should be conducted to explore changes in public knowledge and attitudes towards COVID-19 in the future. The media could be used in a strict and regular manner to publicize knowledge of such pandemics to halt their spread.

scholarly journals How frequent are acute reactions to COVID-19 vaccination and who is at risk?

2021 ◽  
Author(s):  
Nancy A Dreyer ◽  
Matthew W Reynolds ◽  
Lisa M Albert ◽  
Emma Brinkley ◽  
Tom Kwon ◽  
...  
Keyword(s):  
Side Effects ◽  
Medical Care ◽  
Side Effect ◽  
Median Number ◽  
Long Term Effects ◽  
Short Term ◽  
Web Based ◽  
Post Vaccination ◽  
Life Impact ◽  
The Usa

Introduction: Our objective was to describe and compare self-reported side effects of COVID-19 vaccines in the USA. Methods: A web-based registry enrolled volunteers who received a COVID-19 vaccine between March 19 and July 15, 2021. We collected self-reported short-term side effects, medical consultation, hospitalization, and quality of life impact following completed vaccination regimens (Pfizer, Moderna, J&J). Results: We recruited 6,966 volunteers who completed their full course of vaccination (median age 48 years, IQR 35.0-62.0; 83.6% female): Pfizer 3,486; Moderna 2,857; J&J 623. Few (3.1%) sought medical care for post-vaccination side effects. Hospitalization (n=17; 0.3%) and severe allergic reactions (n=39; 0.6%) also were rare. Those with autoimmune disease or lung disease were approximately twice as likely to seek medical care (adjusted odds ratio (aOR) 2.01 [95% CI: 1.39;2.92] and 1.70 [95% CI: 1.12;2.58] respectively). 92.4% of participants reported >1 side effect (median 3), with injection site reactions (78.9%), fatigue (70.3%), headache (49.0%) reported most frequently. More side effects were reported after the second dose of two-dose vaccines (medians: 1 vs. 2 for Pfizer and 1 vs. 3 for Moderna for first and second doses respectively) versus 3 for J&J's single-dose vaccine. For the employed, the median number of workdays missed was one. Diabetics and those vaccinated against influenza were substantially less likely to report >3 symptoms (aOR 0.68, 95% CI 0.56,0.82 and aOR 0.82, 95% CI 0.73,0.93, respectively.) Discussion: The total side effect burden was, not unexpectedly, greater with two-dose regimens but all three vaccines appear relatively safe. Very few subjects reported side effects serious enough to warrant medical care or reported post-vaccination hospitalization. While these findings do not address possible long-term effects, they do inform on their short-term safety and tolerability and will hopefully provide some reassurance and positively inform the benefit-risk and pharmacoeconomic assessment for all three vaccines. Clinicaltrials.gov NCT04368065

scholarly journals Development of an interactive, agent-based local stochastic model of COVID-19 transmission and evaluation of mitigation strategies illustrated for the state of Massachusetts, USA

2020 ◽  
Author(s):  
Alexander Kirpich ◽  
Vladimir Koniukhovskii ◽  
Vladimir Shvartc ◽  
Pavel Skums ◽  
Thomas A. Weppelmann ◽  
...  
Keyword(s):  
Population Data ◽  
The United States ◽  
The State ◽  
Mitigation Strategies ◽  
Effective Vaccine ◽  
Modeling Framework ◽  
Web Based ◽  
Agent Based ◽  
Isolation Techniques ◽  
Novel Coronavirus

Since its discovery in the Hubei province of China, the global spread of the novel coronavirus SARS-CoV-2 has resulted in millions of COVID-19 cases and hundreds of thousands of deaths. The spread throughout Asia, Europe, and the Americas has presented one of the greatest infectious disease threats in recent history and has tested the capacity of global health infrastructures. Since no effective vaccine is available, isolation techniques to prevent infection such as home quarantine and social distancing while in public have remained the cornerstone of public health interventions. While government and health officials were charged with implementing stay-at-home strategies, many of which had little guidance as to the consequences of how quickly to begin them. Moreover, as the local epidemic curves have been flattened, the same officials must wrestle with when to ease or cease such restrictions as to not impose economic turmoil. To evaluate the effects of quarantine strategies during the initial epidemic, an agent based modeling framework was created to take into account local spread based on geographic and population data with a corresponding interactive desktop and web-based application. Using the state of Massachusetts in the United States of America, we have illustrated the consequences of implementing quarantines at different time points after the initial seeding of the state with COVID-19 cases. Furthermore, we suggest that this application can be adapted to other states, small countries, or regions within a country to provide decision makers with critical information necessary to best protect human health.

scholarly journals Awareness and Impact of Hydroxychloroquine / Chloroquine prophylaxis among the Healthcare Workers during the COVID-19 Pandemic: An observational study.

2020 ◽  
Author(s):  
Silky Dhamija ◽  
Yayati Joshi ◽  
Amar Nandhakumar
Keyword(s):  
Side Effects ◽  
Healthcare Workers ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Web Based ◽  
Care Workers ◽  
Novel Coronavirus ◽  
Adequate Research ◽  
Morbid Conditions

Abstract Background Various modalities are under study for prevention and treatment of novel coronavirus. One such modality is use of Hydroxychloroquine/Choloroquine. The objective of survey was to understand the awareness and impact of HCQ/CQ prophylaxis among the health care workers (HCWs) including surgeons and anaesthetists.Methods A web-based, cross-sectional survey was conducted for HCWs globally. Participation was voluntary and confidentiality was maintained by making participants' information anonymous. The questionnaire consisted of 28 items. Data were tabulated in excel, and descriptive statistics were performed. Results Survey was taken by 344 HCWs from all over the world. 98% participants heard about the use of HCQ/CQ prophylaxis against COVID 19 infection. 301 HCWs knew about the side effects of HCQ/CQ. 54 1% participants agree there is not adequate research done. 122 participants took HCQ/CQ prophylaxis. Out of 29 5% participants who received the medicine from hospital under hospital protocol, 66 7% were given medication without baseline investigations and 30 5% HCWs were not even briefed about the drug and its side effects by the hospitals. 36 2% participants developed side effects. 8 7% HCWs were tested for COVID19 out of 344 participants.Conclusion The drug taken by HCWs was without adequate evidence, prior investigations, supervision and follow-up. Most of the participants self prescribed the drug. No separate guidelines were stated for people who had co-morbid conditions. Hospitals neither conducted baseline investigations and nor briefed HCWs about HCQ/CQ. These are some serious concerns we are looking into as who will be answerable in case of adverse events.

scholarly journals Benign Fasciculation Syndrome and Migraine Aura without Headache: Possible Rare Side Effects of the BNT162b2 mRNA Vaccine? A Case Report and a Potential Hypothesis

Vaccines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 117
Author(s):  
Grgur Salai ◽  
Ervina Bilic ◽  
Dragan Primorac ◽  
Darija Mahovic Lakusic ◽  
Hrvoje Bilic ◽  
...  
Keyword(s):  
Adverse Event ◽  
Case Report ◽  
Side Effects ◽  
Causal Relation ◽  
Effective Vaccine ◽  
Migraine Aura ◽  
Post Vaccination ◽  
Adverse Event Following Immunization ◽  
Muscle Groups ◽  
Almost All

The BNT162b2 (Pfizer BioNTech) mRNA vaccine is an effective vaccine against COVID-19 infection. Here, we report an adverse event following immunization (AEFI) in a 48-year-old female patient who presented with fasciculations, migraine auras without headaches and in an increased discomfort of previously present palpitations, as well as excitation and insomnia. Her fasciculations were intermittently present until the time this paper was written, starting from the 6th day post-vaccination; they changed localization and frequency, but most commonly they were generalized, affecting almost all muscle groups. The patient also suffered from two incidents of migraine auras with visual kaleidoscope-like phenomena without headaches a few months after the vaccination. These symptoms were considered to be AEFI and no causal relation with the vaccine could be proven.

scholarly journals Development of an interactive, agent-based local stochastic model of COVID-19 transmission and evaluation of mitigation strategies illustrated for the state of Massachusetts, USA

PLoS ONE ◽  
2021 ◽  
Vol 16 (2) ◽  
pp. e0247182
Author(s):  
Alexander Kirpich ◽  
Vladimir Koniukhovskii ◽  
Vladimir Shvartc ◽  
Pavel Skums ◽  
Thomas A. Weppelmann ◽  
...  
Keyword(s):  
Population Data ◽  
The United States ◽  
The State ◽  
Mitigation Strategies ◽  
Effective Vaccine ◽  
Modeling Framework ◽  
Web Based ◽  
Agent Based ◽  
Isolation Techniques ◽  
Novel Coronavirus

Since its discovery in the Hubei province of China, the global spread of the novel coronavirus SARS-CoV-2 has resulted in millions of COVID-19 cases and hundreds of thousands of deaths. The spread throughout Asia, Europe, and the Americas has presented one of the greatest infectious disease threats in recent history and has tested the capacity of global health infrastructures. Since no effective vaccine is available, isolation techniques to prevent infection such as home quarantine and social distancing while in public have remained the cornerstone of public health interventions. While government and health officials were charged with implementing stay-at-home strategies, many of which had little guidance as to the consequences of how quickly to begin them. Moreover, as the local epidemic curves have been flattened, the same officials must wrestle with when to ease or cease such restrictions as to not impose economic turmoil. To evaluate the effects of quarantine strategies during the initial epidemic, an agent based modeling framework was created to take into account local spread based on geographic and population data with a corresponding interactive desktop and web-based application. Using the state of Massachusetts in the United States of America, we have illustrated the consequences of implementing quarantines at different time points after the initial seeding of the state with COVID-19 cases. Furthermore, we suggest that this application can be adapted to other states, small countries, or regions within a country to provide decision makers with critical information necessary to best protect human health.

scholarly journals Identification of susceptibility loci for adverse events following COVID-19 vaccination in the Japanese population: A web-based genome-wide association study.

2021 ◽  
Author(s):  
Shun Nogawa ◽  
Hajime Kanamori ◽  
Koichi Tokuda ◽  
Kaoru Kawafune ◽  
Miyuki Chijiiwa ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Events ◽  
Genome Wide Association Study ◽  
Association Studies ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
The Novel ◽  
Web Based ◽  
Genome Wide ◽  
Novel Coronavirus

The novel coronavirus disease 2019 (COVID-19) pandemic has spread rapidly worldwide. To prevent the spread of COVID-19, mRNA-based vaccines made by Pfizer/BioNTech (BNT162b1) and Moderna (mRNA-1273) have been widely used worldwide, including in Japan. Various adverse events after COVID-19 mRNA vaccinations have been reported, with differences observed among individuals. However, the analysis on the genetic background for susceptibility to side effects has been limited. In the present work, we performed genome-wide association studies (GWAS) for self-reported adverse events of COVID-19 mRNA vaccination in 4,545 Japanese individuals and identified 14 associated loci. Among these, 6p21 was associated with 37.5°C or higher fever, 38 °C or higher fever, and muscle pain. Our results may enable one to prepare for and manage side effects by knowing their susceptibility to the occurrence of adverse events. Furthermore, we obtained valuable data that can lead to the understanding of the mechanism of action of COVID-19 mRNA vaccines.

Telehealth During COVID-19 for Remote Vision Rehabilitation of a Patient with mTBI

2020 ◽  
pp. 191-198
Keyword(s):  
Veterans Health ◽  
Health Administration ◽  
Web Based ◽  
Home Setting ◽  
Therapeutic Goals ◽  
Vision Rehabilitation ◽  
Novel Coronavirus ◽  
Performance Challenges ◽  
Perception Of Performance

Background: Binocular and accommodative vision problems are common after mild traumatic brain injury (mTBI). Traditionally, the management of visual dysfunctions following mTBI included in-office vision rehabilitation with a trained eye care provider. The concept of providing telehealth for remote vision rehabilitation in mTBI patients is a relatively novel practice that has not been widely utilized until the recent outbreak of the 2019 novel coronavirus (COVID-19) pandemic. Case Report: We describe the implementation of telehealth for remote vision rehabilitation during COVID-19 within the Veterans’ Health Administration (VHA) system in an adult patient with multiple confirmed histories of mTBI. Conclusion: Our telehealth remote vision rehabilitation was successfully implemented utilizing established VHA’s web-based videoconferencing tools. Therapeutic goals identified prior to COVID 19 were addressed without any challenges. The delivery of vision rehabilitation intervention via telehealth allowed for the continuance of services within the home setting that led to improvements in functional vision, decreased perception of performance challenges, and improved quality of life.

Critical Insight into the Attributes of Emerging Novel Coronavirus (COVID-19) in India and Across the World

Coronaviruses ◽  
2020 ◽  
Vol 1 (1) ◽  
pp. 49-56
Author(s):  
Gaurav M. Doshi ◽  
Hemen S. Ved ◽  
Ami P. Thakkar
Keyword(s):  
Review Article ◽  
World Health ◽  
Effective Vaccine ◽  
Human Contact ◽  
The World ◽  
Critical Insight ◽  
Novel Coronavirus ◽  
Health Organization ◽  
Insight Into ◽  
Old Drugs

The World Health Organization (WHO) has recently announced the spread of novel coronavirus (nCoV) globally and has declared it a pandemic. The probable source of transmission of the virus, which is from animal to human and human to human contact, has been established. As per the statistics reported by the WHO on 11th April 2020, data has shown that more than sixteen lakh confirmed cases have been identified globally. The reported cases related to nCoV in India have been rising substantially. The review article discusses the characteristics of nCoV in detail with the probability of potentially effective old drugs that may inhibit the virus. The research may further emphasize and draw the attention of the world towards the development of an effective vaccine as well as alternative therapies. Moreover, the article will help to bridge the gap between the new researchers since it’s the current thrust area of research.

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