Effects of Litter Size and Parity Number on Mammary Secretions Including, Insulin-Like Growth Factor-1, Immunoglobulin G and Vitamin A of Black Bengal, Saanen and Their Crossbred Goats in Thailand

The present study aims to investigate the composition including concentrations of IGF-1, IgG and Vit A in colostrum and their effects by litter size and goat parity in 3 groups of goats; Black Bengal (BB), Saanen (SA) and their crossbred (BBSA). Thirty-eight goats were used (23 BB, 7 BBSA and 8 SA). The composition (fat, protein, lactose and total solid; TS) in colostrum (Day 0; D0) and milk (Day 4; D4 and Day 7; D7) were measured. The IGF-1, IgG concentrations were analysed in some samples collected at D0, D4 and D7 while Vit A was analysed only in colostrum. The results showed that colostrum components were similar among experimental groups. However, the colostral IGF-1 concentration of BBSA (983.0 ± 163.6 ng/mL) was higher than that of BB (340.7 ± 85.5 ng/mL, p < 0.01) and SA (417.1 ± 93.9 ng/mL, p < 0.01). The colostral IgG concentration of BB (8.2 ± 0.9 mg/mL) was lower than that of BBSA (12.9 ± 1.7 mg/mL, p < 0.05) and SA (12.9 ± 1.0 mg/mL, p < 0.01). Colostral Vit A concentration in BBSA (787.2 ± 152.6 µg/100 gm) was higher than that in BB (388.9 ± 84.3 µg/100 gm, p < 0.05) but was not different from SA (522.8 ± 96.9 µg/100 gm). Colostrum from all groups contained higher protein and TS but was lower in lactose concentration than milk. The IGF-1 and IgG concentrations in colostrum were much higher than in milk both D4 and D7 (p < 0.001). Additionally, litter size had no effects on colostrum contents but colostrum from goats with a higher parity number had higher IgG concentration. It is concluded that colostrum from BBSA may be superior when fed to BB newborn goats in terms of higher IGF-1, IgG and Vit A contents. Moreover, colostrum from goats with a high parity number contained more IgG content.

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Impact of insulin‐like growth factor 1, immunoglobulin G and vitamin A in colostrum on growth of newborn Black Bengal goats and its crossbred

Journal of Animal Physiology and Animal Nutrition ◽

10.1111/jpn.13671 ◽

2021 ◽

Author(s):

Chollada Buranakarl ◽

Sumpun Thammacharoen ◽

Sapon Semsirmboon ◽

Saikaew Sutayatram ◽

Morakot Nuntapaitoon ◽

...

Keyword(s):

Growth Factor ◽

Vitamin A ◽

Immunoglobulin G ◽

Insulin Like Growth Factor

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Variation in Plasma Concentration of Insulin-like Growth Factor-l and its Covariation with Liveweight in Mice

Australian Journal of Biological Sciences ◽

10.1071/bi9870287 ◽

1987 ◽

Vol 40 (3) ◽

pp. 287 ◽

Cited By ~ 18

Author(s):

H T Blair ◽

SN McCutcheon ◽

DDS Mackenzie ◽

PD Gluckman ◽

JE Ormsby

Keyword(s):

Genetic Variation ◽

Plasma Concentration ◽

Growth Factor ◽

Litter Size ◽

Genetic Factors ◽

Plasma Concentrations ◽

Early Age ◽

Selection Experiment ◽

Insulin Like Growth Factor ◽

The Relationship

Three experiments were undertaken to examine the degree and causes of variation in plasma concentrations of insulin-like growth factor-l (IOF-I) in mice. The relationship between IOF-l concentrations and liveweight was also examined. In all three experiments, a number of non-genetic factors were found to contribute significantly to the variation in IOF-l concentrations, the most important of these being sex and litter size. In one experiment, where pups from 16 litters were cross-fostered to avoid the confounding of maternal and direct genetic effects, a heritability of 0'40 � 0�27 was estimated for plasma IOF-l concentration at 35 days of age. To examine further the existence of genetic variation in plasma concentrations of IOF-l and the genetic covariation between plasma IOF-l levels and other body traits, a selection experiment with mice has been initiated. Moderate to strong phenotypic correlations between IOF-l concentrations and weight at an early age have been found in all three experiments.

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Placental insulin-like growth factor II (IGF-II) and its relation to litter size in the common marmoset monkey (Callithrix jacchus)

American Journal of Primatology ◽

10.1002/ajp.20739 ◽

2009 ◽

Vol 71 (12) ◽

pp. 969-975 ◽

Cited By ~ 5

Author(s):

Julienne N. Rutherford ◽

Amy Eklund ◽

Suzette Tardif

Keyword(s):

Growth Factor ◽

Litter Size ◽

Common Marmoset ◽

Callithrix Jacchus ◽

Insulin Like Growth Factor ◽

Marmoset Monkey ◽

Factor Ii ◽

The Common

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Blood Concentrations of Growth Hormone, Insulin-Like Growth Factor-1, Thyroid Hormone and Vitamin A in Japanese Black Calves with Retarded Growth

Journal of the Japan Veterinary Medical Association ◽

10.12935/jvma1951.52.427 ◽

1999 ◽

Vol 52 (7) ◽

pp. 427-430 ◽

Cited By ~ 8

Author(s):

Mizuho ISHIBASHI ◽

Kanji USHINOHAMA ◽

Syunichi KAMIMURA ◽

Katsumi HAMANA

Keyword(s):

Growth Hormone ◽

Growth Factor ◽

Thyroid Hormone ◽

Vitamin A ◽

Insulin Like Growth Factor ◽

Blood Concentrations ◽

Retarded Growth

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The Effect of Insulin-Like Growth Factor-I of Pregnant Crossbred Mare Serum and Insulin-Like Growth Factor-I Recombinant Mouse on Estrous Cycles and Litter Sizes of Mice (Mus musculus)

KnE Life Sciences ◽

10.18502/kls.v3i6.1126 ◽

2017 ◽

Vol 3 (6) ◽

pp. 175

Author(s):

Tjuk Imam Restiadi ◽

Imam Mustofa ◽

Suzanita Utama ◽

Sri Mulyati

Keyword(s):

Growth Factor ◽

Estrous Cycle ◽

Litter Size ◽

Mus Musculus ◽

Insulin Like Growth Factor ◽

Estrous Cycles ◽

Factor I ◽

Recombinant Mouse ◽

Igf I ◽

Growth Factor I

The research was conducted to determine the effect of insulin-like growth factor-I (IGF-I) derived from pregnant crossbred mare serum (PMS) on estrous cycle and litter size in mice (Mus musculus). The research was arranged by Completely Randomized Design (CRD) with seven treatments and five replications. The treatments were control (CO)= physiological NaCl, treatment (T) 1 = 10 ng/ml of IGF-I pregnant mares crossbred serum (PMS), T2 = 20 ng/ml of IGF-I PMS, T3 = 40 ng/ml of IGF-I PMS, T4 = 10 ng/ml of IGF-I recombinant mouse, T5 = 20 ng/ml of IGF-I recombinant mouse, and T6 = 40 ng/ml of IGF-I recombinant mouse. Serie I the subject of this research were 35 female mice. Observed variables included estrous cycle phases that proestrus, estrus, metestrus, and diestrus phase. Serie II for the objects of this research were 35 female mice and 21 male mice in the same treatment on litter size in mice. The data were analyzed by Analysis of Variance (ANOVA), followed by HSD (Honestly Significant Difference) test. The result showed that the addition of IGF-I PMS did not significantly affect (p>0.05) on proestrus, metestrus, and diestrus phase. The addition of IGF-I PMS 40 ng/ml was extended (p<0.05) the estrus phase. It showed that there was not significantly difference (p>0.05) between the effect of IGF-I PMS and IGF-I recombinant mouse with the mice estrous cycles. The result of IGF-I derived from PMS and IGF-I recombinant mouse on litter size in mice did not significantly difference (p>0.05). Test results shows significant differences between control and 40 ng/ml of IGF-I PMS. Keywords: IGF-I, IGF-I pregnant crossbred mare serum, estrous cycle, litter sizes, Mus musculus

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Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep

Molecular Biology Reports ◽

10.1007/s11033-012-1846-y ◽

2012 ◽

Vol 39 (10) ◽

pp. 9801-9807 ◽

Cited By ~ 18

Author(s):

J. N. He ◽

B. Y. Zhang ◽

M. X. Chu ◽

P. Q. Wang ◽

T. Feng ◽

...

Keyword(s):

Growth Factor ◽

Litter Size ◽

Insulin Like Growth Factor

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ELEVATING MATERNAL INSULIN-LIKE GROWTH FACTOR-I IN MICE AND RATS ALTERS THE PATTERN OF FETAL GROWTH BY REMOVING MATERNAL CONSTRAINT

Journal of Endocrinology ◽

10.1677/joe.0.134r001 ◽

1992 ◽

Vol 134 (1) ◽

pp. R1-R3 ◽

Cited By ~ 52

Author(s):

P.D. Gluckman ◽

P.C.H. Morel ◽

G.R. Ambler ◽

B.H. Breier ◽

H.T. Blair ◽

...

Keyword(s):

Body Weight ◽

Growth Factor ◽

Litter Size ◽

Fetal Growth ◽

Negative Relationship ◽

Late Gestation ◽

Fetal Weight ◽

Insulin Like Growth Factor ◽

Direct Role ◽

Igf I

ABSTRACT Fetal growth is normally constrained by maternal factors. This constraint is demonstrated by the usual inverse linear relationship between litter size and mean fetal weight. Cross-breeding experiments between mice of lines selected for high or low plasma insulin-like growth factor (IGF-I) levels suggested that elevations in maternal IGF-I abolish (P <0.01) this constraining effect and reverse the usual positive relationship between fetal and placental size in late gestation. This was confirmed by treating mice and rats throughout pregnancy with IGF-I. In normal mice and in low IGF-I line mice treatment with IGF-I 10μg 8-hourly s.c. from day 1 to 19 of pregnancy) abolished maternal constraint whereas 0.9% (w/v) NaCl treatment did not. In Wistar rats osmotic pumps were implanted to deliver IGF-I (1μg/g body weight per day), bovine GH (bGH; 0.6μg/g body weight per day) or saline from day 1 to 19 of pregnancy. IGF-I therapy but not bGH or saline abolished (P < 0.01) maternal constraint and altered (P <0.01) the relationship between placental and fetal weight. When high or low IGF-I line mice embryos were transplanted into a normal line of mice, the expected negative relationship (P <0.05) between mean fetal weight and litter size was maintained. However the embryos of the high line were heavier (P <0.05) than those from the low line irrespective of fetal number, suggesting a direct role for IGF-I in the regulation of fetal growth. Thus both endogenous and exogenous elevations in maternal IGF-I indirectly promote fetal growth either by altering nutrient delivery to the placenta or by affecting placental function.

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