scholarly journals Environmental impact ratings that could drive positive environmental changes in the manufacture and use of pharmaceuticals

BJGP Open ◽  
2021 ◽  
pp. BJGPO.2021.0214
Author(s):  
Amelia Cussans ◽  
Guy Harvey ◽  
Terry Kemple ◽  
Tracy Lyons ◽  
Mike Tomson ◽  
...  
2020 ◽  
Vol 8 (2) ◽  
pp. 54-62
Author(s):  
Mekonen Aregai ◽  
Muluberhan Bedemariam

AbstractThis article presents research on the socio environmental impact of refugees on their host communities. We assessed the challenges of refuge populations to their host community in north western Tigray, Ethiopia, where the Eritrean refugees are settled,. Primary data was produced from semi-structured questionnaires and a random sampling technique deploying a logistic regression model to describe the relationship between the socio-environmental changes of the host community. Results suggested 96% of the sample respondents confirmed changes of tree species and forest coverage on community farms was observed during the study period. Similarly, change in forest coverage and changes in tree species are strongly and positively associated with the existence of refugees in the study communities. The dramatic change observed on forest coverage and tree species has led to a progressive decline in natural resources. The study concluded that unplanned human population influxes, especially refugee inflows, affected host communities negatively and the socio-environmental situation has been significantly changed in the study areas. The study highlights the need for holistic intervention to ameliorate the negative impacts and to maintain the sustainable management of natural resources so as to improve the socio-environmental impact of refugees on host communities.


2016 ◽  
Author(s):  
J. Coston-Guarini ◽  
J-M Guarini ◽  
J. Edmunds ◽  
Shawn Hinz ◽  
Jeff Wilson ◽  
...  

ABSTRACTA new roadmap for quantitative methodologies of Environmental Impact Assessment (EIA) is proposed, using an ecosystem-based approach. EIA recommendations are currently based on case-by-case rankings, distant from statistical methodologies, and based on ecological ideas that lack proof of generality or predictive capacities. These qualitative approaches ignore process dynamics, scales of variations and interdependencies and are unable to address societal demands to link socio-economic and ecological processes (e.g. population dynamics). We propose to re-focus EIA around the systemic formulation of interactions between organisms (organized in populations and communities) and their environments but inserted within a strict statistical framework. A systemic formulation allows scenarios to be built that simulate impacts on chosen receptors. To illustrate the approach, we design a minimum ecosystem model that demonstrates non-trivial effects and complex responses to environmental changes. We suggest further that an Ecosystem-Based EIA - in which the socio-economic system is an evolving driver of the ecological one - is more promising than a socio-economic-ecological system where all variables are treated as equal. This refocuses the debate on cause-and-effect, processes, identification of essential portable variables, and a potential for quantitative comparisons between projects, which is important in cumulative effects determinations.


1989 ◽  
Vol 21 (3) ◽  
pp. 21-26 ◽  
Author(s):  
Renate Walter ◽  
H. Kaupa ◽  
Margrit Johl ◽  
Jutta Dürkop ◽  
Ursula Krämer ◽  
...  

The construction of the Marchfeldkanalsystem (Austria) creates irreversible environmental changes which could have an impact on environmental health. Virological investigations of the river Danube have been carried out as a part of the environmental impact assessment procedure. The repeated detection of viruses in 61% of all water samples with a mean level of 0.762 MPN/l suggests that a permanent viral contamination of Danube is occurring and that the self-purifying capacity of the river is relatively inefficient. Strains of some virus families not hitherto detected in water (toga-(bunya) viridae) could be found. Provided the proposed treatment facilities are as effective as to remove the virus load to an extent of 99.99% the Marchfeldkanalsystem project will not endanger public health.


2017 ◽  
Vol 74 (7) ◽  
pp. 2012-2023 ◽  
Author(s):  
J. Coston-Guarini ◽  
J.-M. Guarini ◽  
Shawn Hinz ◽  
Jeff Wilson ◽  
L. Chauvaud

Abstract A new roadmap for quantitative methodologies of Environmental Impact Assessment (EIA) is proposed, using an ecosystem-based approach. EIA recommendations are currently based on case-by-case rankings, distant from statistical methodologies, and ecological ideas that lack proof of generality or predictive capacities. These qualitative approaches ignore process dynamics, scales of variations and interdependencies and are unable to address societal demands to link socio-economic and ecological processes (e.g. population dynamics). We propose to re-focus EIA around the systemic formulation of interactions between organisms (organized in populations and communities) and their environments but inserted within a strict statistical framework. A systemic formulation allows scenarios to be built that simulate impacts on chosen receptors. To illustrate the approach, we design a minimum ecosystem model that demonstrates nontrivial effects and complex responses to environmental changes and validated with case study. We suggest that an Ecosystem-Based EIA—in which the socio-economic system is an evolving driver of the ecological one—is more promising than a socio-economic-ecological system where all variables are treated as equal. This refocuses the debate on cause-and-effect, processes, identification of essential portable variables, and allows for quantitative comparisons between projects, which is critical in cumulative effects determinations.


2020 ◽  
Vol 477 (16) ◽  
pp. 3091-3104 ◽  
Author(s):  
Luciana E. Giono ◽  
Alberto R. Kornblihtt

Gene expression is an intricately regulated process that is at the basis of cell differentiation, the maintenance of cell identity and the cellular responses to environmental changes. Alternative splicing, the process by which multiple functionally distinct transcripts are generated from a single gene, is one of the main mechanisms that contribute to expand the coding capacity of genomes and help explain the level of complexity achieved by higher organisms. Eukaryotic transcription is subject to multiple layers of regulation both intrinsic — such as promoter structure — and dynamic, allowing the cell to respond to internal and external signals. Similarly, alternative splicing choices are affected by all of these aspects, mainly through the regulation of transcription elongation, making it a regulatory knob on a par with the regulation of gene expression levels. This review aims to recapitulate some of the history and stepping-stones that led to the paradigms held today about transcription and splicing regulation, with major focus on transcription elongation and its effect on alternative splicing.


2019 ◽  
Vol 3 (5) ◽  
pp. 435-443 ◽  
Author(s):  
Addy Pross

Despite the considerable advances in molecular biology over the past several decades, the nature of the physical–chemical process by which inanimate matter become transformed into simplest life remains elusive. In this review, we describe recent advances in a relatively new area of chemistry, systems chemistry, which attempts to uncover the physical–chemical principles underlying that remarkable transformation. A significant development has been the discovery that within the space of chemical potentiality there exists a largely unexplored kinetic domain which could be termed dynamic kinetic chemistry. Our analysis suggests that all biological systems and associated sub-systems belong to this distinct domain, thereby facilitating the placement of biological systems within a coherent physical/chemical framework. That discovery offers new insights into the origin of life process, as well as opening the door toward the preparation of active materials able to self-heal, adapt to environmental changes, even communicate, mimicking what transpires routinely in the biological world. The road to simplest proto-life appears to be opening up.


2019 ◽  
Author(s):  
M Hänsel ◽  
T Bambach ◽  
H Wachtel
Keyword(s):  

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