Faculty Opinions recommendation of Vdelta1+ gammadelta T cells producing CC chemokines may bridge a gap between neutrophils and macrophages in innate immunity during Escherichia coli infection in mice.

2004 ◽  
Author(s):  
Eric Denkers
Keyword(s):  
Escherichia Coli ◽  
Innate Immunity ◽  
T Cells ◽  
Gammadelta T Cells ◽  
Escherichia Coli Infection ◽  
Cc Chemokines

scholarly journals Zebrafish nephrosin helps host defence against Escherichia coli infection

Open Biology ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. 170040 ◽  
Author(s):  
Qianqian Di ◽  
Qing Lin ◽  
Zhibin Huang ◽  
Yali Chi ◽  
Xiaohui Chen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Innate Immunity ◽  
Host Defence ◽  
Bacterial Burden ◽  
Wild Type ◽  
Lower Survival Rate ◽  
E Coli ◽  
Escherichia Coli Infection ◽  
Effective Models

Neutrophils play important roles in innate immunity and are mainly dependent on various enzyme-containing granules to kill engulfed microorganisms. Zebrafish nephrosin ( npsn ) is specifically expressed in neutrophils; however, its function is largely unknown. Here, we generated an npsn mutant ( npsn smu5 ) via CRISPR/Cas9 to investigate the in vivo function of Npsn. The overall development and number of neutrophils remained unchanged in npsn -deficient mutants, whereas neutrophil antibacterial function was defective. Upon infection with Escherichia coli , the npsn smu5 mutants exhibited a lower survival rate and more severe bacterial burden, as well as augmented inflammatory response to challenge with infection when compared with wild-type embryos, whereas npsn -overexpressing zebrafish exhibited enhanced host defence against E. coli infection. These findings demonstrated that zebrafish Npsn promotes host defence against bacterial infection. Furthermore, our findings suggested that npsn -deficient and -overexpressing zebrafish might serve as effective models of in vivo innate immunity.

scholarly journals Protective Roles of γδ T Cells and Interleukin-15 in Escherichia coli Infection in Mice

1998 ◽  
Vol 66 (7) ◽  
pp. 3270-3278 ◽  
Author(s):  
M. Takano ◽  
H. Nishimura ◽  
Y. Kimura ◽  
Y. Mokuno ◽  
J. Washizu ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Monoclonal Antibody ◽  
T Cells ◽  
T Cell Receptor ◽  
Host Defense ◽  
Γδ T Cells ◽  
Cell Receptor ◽  
E Coli ◽  
Escherichia Coli Infection ◽  
Interleukin 15

The number of γδ T cells in the peritoneal cavity was increased after an intraperitoneal (i.p.) infection with Escherichia coli in lipopolysaccharide (LPS)-responsive C3H/HeN mice but not in LPS-hyporesponsive C3H/HeJ mice. The γδ T cells preferentially expressed invariant Vγ6 and Vδ1 chains and proliferated to produce a large amount of gamma interferon in the presence of LPS. Mice depleted of γδ T cells by T-cell receptor δ gene mutation showed impaired resistance against E. coli as assessed by bacterial growth. Macrophages from C3H/HeN mice infected with E. coli expressed higher levels of interleukin-15 (IL-15) mRNA than those from the infected C3H/HeJ mice. Administration of anti-IL-15 monoclonal antibody inhibited, albeit partially, the appearance of γδ T cells in C3H/HeN mice after E. coli infection and diminished the host defense against the infection. These results suggest that LPS-stimulated γδ T cells play an important role in the host defense against E. coli infection and that IL-15 may be partly involved in the protection via an increase in the γδ T cells.

scholarly journals Vδ1+γδ T Cells Producing CC Chemokines May Bridge a Gap between Neutrophils and Macrophages in Innate Immunity duringEscherichia coliInfection in Mice

2004 ◽  
Vol 173 (8) ◽  
pp. 5156-5164 ◽  
Author(s):  
Tetsuzo Tagawa ◽  
Hitoshi Nishimura ◽  
Toshiki Yajima ◽  
Hiromitsu Hara ◽  
Kenji Kishihara ◽  
...  
Keyword(s):  
Innate Immunity ◽  
T Cells ◽  
Γδ T Cells ◽  
Cc Chemokines

l-Glutamine and l-arginine protect against enterotoxigenic Escherichia coli infection via intestinal innate immunity in mice

Amino Acids ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 1945-1954 ◽  
Author(s):  
Gang Liu ◽  
Wenkai Ren ◽  
Jun Fang ◽  
Chien-An Andy Hu ◽  
Guiping Guan ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Innate Immunity ◽  
Enterotoxigenic Escherichia Coli ◽  
Escherichia Coli Infection

Innate Immunity and HIV-1 Infection

2011 ◽  
Vol 23 (1) ◽  
pp. 19-22 ◽  
Author(s):  
T. Lehner ◽  
Y. Wang ◽  
T. Whittall ◽  
T. Seidl
Keyword(s):  
Immune Response ◽  
Innate Immunity ◽  
T Cells ◽  
Γδ T Cells ◽  
Host Cells ◽  
Effector Memory ◽  
Mucosal Tissues ◽  
Cc Chemokines ◽  
Anti Hiv ◽  
Hiv 1

HIV-1 is predominantly transmitted through mucosal tissues, targeting CD4+CCR5+ T cells, 50% of which are destroyed within 2 weeks of infection. Conventional vaccination strategies have so far failed to prevent HIV-1 infection. Neither antibodies nor cytotoxic lymphocytes are capable of mounting a sufficiently rapid immune response to prevent early destruction of these cells. However, innate immunity is an early-response system, largely independent of prior encounter with a pathogen. Innate immunity can be classified into cellular, extracellular, and intracellular components, each of which is exemplified in this review by γδ T cells, CC chemokines, and APOBEC3G, respectively. First, γδ T cells are found predominantly in mucosal tissues and produce cytokines, CC chemokines, and antiviral factors. Second, the CC chemokines CCL-3, CCL-4, and CCL-5 can be upregulated by immunization of macaques with SIVgp120 and gag p27, and these can bind and downmodulate CCR5, thereby inhibiting HIV-1 entry into the host cells. Third, APOBEC3G is generated and maintained following rectal mucosal immunization in rhesus macaques for over 17 weeks, and the innate anti-SIV factor is generated by CD4+CD95+CCR7− effector memory T cells. Thus, innate anti-HIV-1 or SIV immunity can be linked with immune memory, mediated by CD4+ T cells generating APOBEC3G. The multiple innate functions may mount an early anti-HIV-1 response and either prevent viral transmission or contain the virus until an effective adaptive immune response develops.

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