Faculty Opinions recommendation of Efficacy of folic acid supplementation in stroke prevention: a meta-analysis.

AbstractWe systematically reviewed the evidence on the association between maternal folic acid supplementation and the risk of offspring’s autism spectrum disorders (ASD). A total of 10 studies with 23 sub-studies (9795 ASD cases) were included. Folic acid supplementation during early pregnancy was associated with a lower risk of offspring’s ASD [OR 0.57, 95% CI 0.41–0.78]. The consumption of a daily amount of at least 400 μg folic acid from dietary sources and supplements, was associated with a reduced risk of offspring ASD [OR 0.55, 95% CI 0.36–0.83]. Critical effective maternal folic acid supplementation strategies, such as intake timing and intake dosage, may aid the reduction in the risk of offspring ASD. This meta-analysis provided new insights for the prevention of offspring’s ASD.

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Compliance with Iron and Folic Acid Supplementation (IFAS) and associated factors among pregnant women in Sub-Saharan Africa: A systematic review and meta-analysis

PLoS ONE ◽

10.1371/journal.pone.0249789 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0249789

Author(s):

Meseret Belete Fite ◽

Kedir Teji Roba ◽

Lemessa Oljira ◽

Abera Kenay Tura ◽

Tesfaye Assebe Yadeta

Keyword(s):

Systematic Review ◽

Folic Acid ◽

Pregnant Women ◽

Meta Analysis ◽

Folic Acid Supplementation ◽

Sub Saharan Africa ◽

Global Public Health ◽

Acid Supplementation ◽

Iron And Folic Acid ◽

Sub Saharan

Background Anemia is one of the world’s leading cause of disability and the most serious global public health issues. This systematic review and meta-analysis was conducted very carefully in order to give up the pooled compliance of Iron and Folic-Acid Supplementation in Sub-Saharan Africa. Methods To conduct this brief systematic review and meta-analysis, a related literature search was done from different sources, PubMed Medline and Google Scholar Journals. Then IFA Supplementation related searching engine was used to make the work more meaningful and intensive. Moreover, we used modified Newcastle-Ottawa quality assessment scale for cross sectional studies to assess the quality of the study in terms of their inclusion. Then, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was followed to carry out the work in a carful manner. Finally, the pooled effect size was computed using the review manager and Compressive Meta-analysis software. Results Twenty-three studies, which encompassed 24272 pregnant women, were chosen for the analysis. From those an overall prevalence of compliance with Iron and Folic Acid Supplementation (IFAS) in pregnancy in SSA was 39.2%. However, the result from meta-analysis showed that women who were counseled on IFAS in their courses of pregnancy were 1.96 times more likely to adhere to IFAS compared to those who were not counseled [OR:1.96, 95% CI (1.76-,5.93)]. Moreover, it showed that women who had knowledge of IFAS were 2.71 times more likely to have compliance with IFAS as compared to those who had no knowledge of IFAS [OR:2.71, 95% CI (1.33,5.54)]. Also it revealed that those women who had knowledge of anemia were 5.42 times more likely to have compliance with IFAS as compared with those who had no knowledge of anemia [OR5.42, 95% CI (1.52, 19.43)]. Furthermore, women who had received fourth visit for ANC were 1.54 times more likely to have compliance with IFAS as compared to those who had not received for ANC [OR 1.54, 95% CI (0.66, 3.58.43)]. Conclusions Our finding from this systematic review and meta-analysis shows the low case in prevalence of compliance to IFAS among pregnant women in SSA. Predictors for this includes: knowledge about anemia, knowledge about IFAS, counseling on IFAS and receiving fourth antenatal care visit were statistically correlated positively with compliance to IFAS. This demands careful appraisal of effect of prevention work for functioning policy, programs and plan nutrition intrusions for refining maternal dietary intake in gestation. Also dietary education intrusion requires to be planned to satisfy the needs of pregnant women. So we hope that the result of this study might be essential as a bridging stone for policy makers of Africa; exclusively for maternal and child health care. Finally, we recommended further studies to be conducted in the area of the study for more intensive and detailed suggestions.

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Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis

Hypertension in Pregnancy ◽

10.1080/10641955.2016.1183673 ◽

2016 ◽

Vol 35 (4) ◽

pp. 447-460 ◽

Cited By ~ 12

Author(s):

Xiaolin Hua ◽

Jiewen Zhang ◽

Yanfang Guo ◽

Minxue Shen ◽

Laura Gaudet ◽

...

Keyword(s):

Systematic Review ◽

Folic Acid ◽

Gestational Hypertension ◽

Meta Analysis ◽

Folic Acid Supplementation ◽

Acid Supplementation

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Association between iron and folic acid supplementation and birth weight in Ethiopia: systemic review and meta analysis

Bulletin of the National Research Centre ◽

10.1186/s42269-021-00595-x ◽

2021 ◽

Vol 45 (1) ◽

Author(s):

Andualem Zenebe ◽

Kaleab Tesfaye Tegegne ◽

Berhanu Bifato ◽

Abiyu Ayalew Assefa

Keyword(s):

Folic Acid ◽

Birth Weight ◽

Low Birth Weight ◽

Meta Analysis ◽

Folic Acid Supplementation ◽

Systemic Review ◽

Cochrane Library ◽

Main Body ◽

Acid Supplementation ◽

Iron And Folic Acid

Abstract Background Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. The aim of the current systemic review and meta-analysis was to examine the relationship between iron and folic acid supplementation and birth weight in Ethiopia. Main body The databases searched were PubMed, Google Scholar, Web of Science and Cochrane Library in January 2021. AZ, KTT and AAA carried out the data extraction and independently assessed the articles for inclusion in the review using risk-of-bias tool guided by PRISMA checklist. The combined Odds ratio with 95% confidence interval was calculated using random effect model. Twenty four observational studies involving 10,989 participants, 2423 newborns who were born LBW were included. The combined effect size (OR) for low birth weight comparing women who have Iron and Folic acid supplementation versus women who did not have iron and folic acid supplementation was 0.39 (95% CI 0.27–0.59, p < 0.00001, I2 = 91%). There was significant heterogeneity (Q = 264.16, I2 = 91%, p < 0.00001). No publication bias was observed (Egger’s test: p = 0.742, Begg’s test: p = 0.372). Overall 69.5% of women reported having iron and folic acid supplementation during current pregnancy. And the overall proportion of low birth weight was 22.1%. Conclusions Women who were supplied with iron and folic acid during pregnancy had a 67% decreased chance of delivering low birth weight new born in Ethiopia.

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The effect of folate fortification on folic acid-based homocysteine-lowering intervention and stroke risk: a meta-analysis

Public Health Nutrition ◽

10.1017/s1368980014002134 ◽

2014 ◽

Vol 18 (8) ◽

pp. 1514-1521 ◽

Cited By ~ 28

Author(s):

Rui Zeng ◽

Chun-Hua Xu ◽

Yuan-Ning Xu ◽

Ya-Li Wang ◽

Mian Wang

Keyword(s):

Folic Acid ◽

Randomized Controlled Trials ◽

Stroke Risk ◽

Meta Analysis ◽

Folic Acid Supplementation ◽

Folate Intake ◽

Controlled Trials ◽

Acid Supplementation ◽

Randomized Controlled ◽

Significant Difference

AbstractObjectiveFolate and vitamin B12 are two vital regulators in the metabolic process of homocysteine, which is a risk factor of atherothrombotic events. Low folate intake or low plasma folate concentration is associated with increased stroke risk. Previous randomized controlled trials presented discordant findings in the effect of folic acid supplementation-based homocysteine lowering on stroke risk. The aim of the present review was to perform a meta-analysis of relevant randomized controlled trials to check the how different folate fortification status might affect the effects of folic acid supplementation in lowering homocysteine and reducing stroke risk.DesignRelevant randomized controlled trials were identified through formal literature search. Homocysteine reduction was compared in subgroups stratified by folate fortification status. Relative risks with 95 % confidence intervals were used as a measure to assess the association between folic acid supplementation and stroke risk.SettingThe meta-analysis included fourteen randomized controlled trials,SubjectsA total of 39 420 patients.ResultsHomocysteine reductions were 26·99 (sd 1·91) %, 18·38 (sd 3·82) % and 21·30 (sd 1·98) %, respectively, in the subgroups without folate fortification, with folate fortification and with partial folate fortification. Significant difference was observed between the subgroups with folate fortification and without folate fortification (P=0·05). The relative risk of stroke was 0·88 (95 % CI 0·77, 1·00, P=0·05) in the subgroup without folate fortification, 0·94 (95 % CI 0·58, 1·54, P=0·82) in the subgroup with folate fortification and 0·91 (95 % CI 0·82, 1·01, P=0·09) in the subgroup with partial folate fortification.ConclusionsFolic acid supplementation might have a modest benefit on stroke prevention in regions without folate fortification.

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Adherence of iron and folic acid supplementation and determinants among pregnant women in Ethiopia: a systematic review and meta-analysis

Reproductive Health ◽

10.1186/s12978-019-0848-9 ◽

2019 ◽

Vol 16 (1) ◽

Cited By ~ 3

Author(s):

Melaku Desta ◽

Bekalu Kassie ◽

Habtamu Chanie ◽

Henok Mulugeta ◽

Tadesse Yirga ◽

...

Keyword(s):

Systematic Review ◽

Folic Acid ◽

Side Effects ◽

Pregnant Women ◽

Meta Analysis ◽

National Level ◽

Folic Acid Supplementation ◽

Acid Supplementation ◽

Life Years ◽

Iron And Folic Acid

Abstract Background Iron and folic acid deficiency anaemia are one of the global public health challenges that pose 1.45% of all disability-adjusted life-years. It is recognized as a cause for an unacceptably high proportion of maternal and perinatal morbidity and mortality. Adherence to iron and folic acid supplementation during the antenatal period is paramount to reduce anaemia and its associated morbidities. Although several studies have been conducted across the country, their reports were inconsistent and inconclusive for intervention. Therefore, this systematic review and meta-analysis were aimed to estimate the pooled national level adherence to iron and folic acid supplementation and its determinants among pregnant women in Ethiopia. Methods This systematic review and meta-analysis were pursued the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2009 guideline. An extensive search of databases including, PubMed, Google Scholar, and African Journals Online were conducted to access articles. The Newcastle- Ottawa quality assessment tool was used to assess the quality of each study and meta-analysis was conducted using a random-effects model. I2 test and Egger’s test were used to assess the heterogeneity and publication bias respectively. The meta-analysis of estimating national level adherence were done using STATA version 11 with 95% CI. Results Twenty studies with a total of 16,818 pregnant women were included in this meta-analysis. The pooled national level iron and folic acid supplementation’s adherence were 46.15% (95%CI:34.75,57.55). The highest adherence was observed in Addis Abeba, 60% (95%CI: 55.93, 64.07) followed by Tigray, 58.9% (95% CI: 33.86, 84.03). Women who received supplemental information [OR = 2.34, 95%CI: 1.05, 5.24], who had good knowledge [OR = 2.2, 95%CI: 1.05, 5.24], began the ANC visit before 16 weeks [OR = 2.41, 95%CI: 1.76, 3.29], and had ≥4 ANC visits [OR = 2.59, 95% CI: 1.09, 6.15] were more likely adhere to the supplementation. Fear of side effects (46.4, 95% CI: 30.9 61.8) and forgetfulness (30.7, 95% CI: 17.6, 43.8) were the major barriers of adherence of the supplementations. Conclusions More than four of nine pregnant women have adhered to the iron and folic acid supplementation. This meta-analysis revealed that receiving supplemental counselling, knowledge of the supplement; early registration and frequent ANC visit were significantly associated with the adherence of the iron and folic acid supplementation. Therefore, provision of strengthened supplemental counselling service, antenatal care services, and improving the knowledge of the supplementation is a crucial strategy to increase the adherence among pregnant women in Ethiopia. Besides, addressing the barriers of the adherence of the supplement mainly counseling or managing of side effects and reducing of forgetfulness to take the tablet through getting family support or male involvement during visit is mandatory.

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Folic Acid Intake and Folate Status and Risk of Cervical Cancer: A Systematic Review and Meta-Analysis from 20 Independent Case-Control Studies and 4 RCTs

Current Developments in Nutrition ◽

10.1093/cdn/nzaa044_029 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 330-330

Author(s):

Yuanxing Li ◽

Aimin Yang ◽

Wei Wang ◽

Zhilian Wang ◽

Zhe Wang ◽

...

Keyword(s):

Cervical Cancer ◽

Folic Acid ◽

Meta Analysis ◽

Folate Deficiency ◽

Folic Acid Supplementation ◽

Case Control ◽

Case Control Studies ◽

Folic Acid Intake ◽

Acid Supplementation ◽

Acid Intake

Abstract Objectives Cervical cancer remains a common public health problem, despite its reduced morbidity and mortality. Exploring diverse prevention and treatment methods is essential. The aim of this meta-analysis was to evaluate the association between folic acid intake and status and the risk of cervical cancer, and discuss the feasibility of folic acid supplement. Methods We identified 369 articles via Ovid MEDLINE, Embase, PubMed, Springer, up to January 2019. Inclusion criteria were case-control study or RCT; folate intake or level was determined; outcomes included CIN and/or cervical cancer; correlations between folate and CIN/cervical cancer were studied; original data were obtained or calculated. We also performed these analyses within groups of studies defined by the following design characteristics: disease outcome (cervical intraepithelial neoplasia CIN, cervical cancer CC), samples resource (serum, plasma, red blood cell, diet record), location (European and American countries, Asian countries). All statistical calculations were performed using R Project software. Results Twenty-two case-control studies and four RCTs were included in the meta- analysis. From 22 case-control studies, there was a strong correlation between folate deficiency and risk of CIN or cancer (OR = 1.46, 95% CI [1.30, 1.63]). The overall analysis results were significantly heterogeneous (I2 = 49%, P < 0.01). The location is the main source of heterogeneity. For Asian regions, folate deficiency is a risk factor for CIN and CC (OR = 1.98, 95% CI [1.47, 2.66]; OR = 2.07, 95% CI [1.43, 3.76], respectively); however, for European and American regions, folate deficiency is only associated with CIN, OR = 1.16, 95% CI [1.01, 1.34]. From 4 RCT studies, the results showed that there was no significant correlation between folic acid supplementation and CIN outcome, RR = 1.17, 95% CI [0.90, 1.51]. Conclusions The overall study showed that folate deficiency significantly increased the risk of CIN and cervical cancer. However, the meta-analysis of 4 RCTs did not show the benefit of folic acid supplementation for CIN regression, probably due to the lack of RCTs, large time span, different folic acid supplementation doses, and different judging criteria of CIN. Further research is needed. Funding Sources N/A.

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