Faculty Opinions recommendation of Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia.

2008 ◽  
Author(s):  
Alfredo Carlo Altamura ◽  
Bernardo Dell'Osso
Keyword(s):  
Oxidative Stress ◽  
Nicotine Dependence ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals Nicotine Dependence, Symptoms and Oxidative Stress in Male Patients with Schizophrenia

2007 ◽  
Vol 32 (9) ◽  
pp. 2020-2024 ◽  
Author(s):  
Xiang Yang Zhang ◽  
Yun Long Tan ◽  
Dong Feng Zhou ◽  
Colin N Haile ◽  
Gui Ying Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nicotine Dependence ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals The Bisphenol A Induced Oxidative Stress in Non-Alcoholic Fatty Liver Disease Male Patients: A Clinical Strategy to Antagonize the Progression of the Disease

2020 ◽  
Vol 17 (10) ◽  
pp. 3369 ◽  
Author(s):  
Alessandro Federico ◽  
Marcello Dallio ◽  
Antonietta Gerarda Gravina ◽  
Nadia Diano ◽  
Sonia Errico ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Bisphenol A ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Free Form ◽  
Alcoholic Fatty Liver ◽  
Male Patients ◽  
And Oxidative Stress ◽  
Alcoholic Fatty Liver Disease

Introduction: Bisphenol A (BPA) exposure has been correlated to non-alcoholic fatty liver disease (NAFLD) development and progression. We investigated, in a clinical model, the effects of the administration of 303 mg of silybin phospholipids complex, 10 μg of vitamin D, and 15 mg of vitamin E (RealSIL, 100D, IBI-Lorenzini, Aprilia, Italy) in male NAFLD patients exposed to BPA on metabolic, hormonal, and oxidative stress-related parameters. Methods: We enrolled 32 male patients with histologic diagnosis of NAFLD and treated them with Realsil 100D twice a day for six months. We performed at baseline clinical, biochemical, and food consumption assessments as well as the evaluation of physical exercise, thiobarbituric acid reactive substances (TBARS), plasmatic and urinary BPA and estrogen levels. The results obtained were compared with those of healthy control subjects and, in the NAFLD group, between baseline and the end of treatment. Results: A direct proportionality between TBARS levels and BPA exposure was shown (p < 0.0001). The therapy determined a reduction of TBARS levels (p = 0.011), an improvement of alanine aminotransferase, aspartate aminotransferase, insulinemia, homeostatic model assessment insulin resistance, C reactive protein, tumor necrosis factor alpha (p < 0.05), an increase of conjugated BPA urine amount, and a reduction of its free form (p < 0.0001; p = 0.0002). Moreover, the therapy caused an increase of plasmatic levels of the native form of estrogens (p = 0.03). Conclusions: We highlighted the potential role of BPA in estrogen oxidation and oxidative stress in NAFLD patients. The use of Realsil 100D could contribute to fast BPA detoxification and to improve cellular antioxidant power, defending the integrity of biological estrogen-dependent pathways.

scholarly journals Novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients

2005 ◽  
Vol 7 (2) ◽  
pp. 121-126 ◽  
Author(s):  
Tamer M. Said ◽  
Nabil Aziz ◽  
Rakesh K. Sharma ◽  
Iwan Lewis-Jones ◽  
Anthony J. Thomas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Infertile Male ◽  
Novel Association ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals The Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia

2014 ◽  
Vol 5 (3) ◽  
pp. 95-99
Author(s):  
Richa Aggarwal
Keyword(s):  
Oxidative Stress ◽  
Semen Analysis ◽  
World Health ◽  
Doxycycline Treatment ◽  
Study Results ◽  
Before And After ◽  
Male Patients ◽  
The Difference ◽  
Health Organization ◽  
And Oxidative Stress

ABSTRACT Objective The World Health Organization (WHO) has defined leukocytospermia as > 106 WBC/ml of semen. However, the clinical significance of leukocytospermia is currently a subject of controversy. Evidence from several recent studies indicates that leukocytospermia could significantly contribute to oxidative stress and male infertility. Several clinical trials have investigated the efficacy of antibiotic therapy to treat patients with pyospermia in an attempt to improve fertility. Currently, doxycycline is the most common antibiotic used to treat pyospermia though larger trials are needed to demonstrate its efficacy in treating pyospermia. Materials and methods Hundred male partners with semen analysis showing the presence of significant leukocytospermia (WBC > 1 × 106/ml), sterile semen culture and satisfying the inclusion and exclusion criteria were enrolled in the study and given doxycycline 100 mg bd for 14 days. Semen analysis for pus cells and oxidative stress (ROS) measurement was done before and after the treatment. Results Mean pus cell count before and after treatment with doxycycline was 2.28 ± 1.26 × 106/ml and 1.21 ± 0.58 ×106/mL respectively, the effect being statistically significant (p < 0.05). Resolution of leukocytospermia was seen in 61.4% (54/88) cases after doxycycline treatment. Mean oxidative stress (RLU/ sec/million sperms) before and after doxycycline therapy was 79.72 ± 133.9 and 25.44 ± 47.8, the difference being significant (p < 0.05). Conclusion Study results show that treatment with broad spectrum antibiotic like doxycycline leads to significant decrease in the number of pus cells present in semen thereby significantly decreasing the oxidative stress. How to cite this article Aggarwal R. the Effect of Doxycycline on Pus Cells and Oxidative Stress in Male Patients with Leukocytospermia. Int J Infertil Fetal Med 2014;5(3):95-99.

Initial and post-treatment total oxidant–antioxidant status and oxidative stress index in male patients with manic episode

2014 ◽  
Vol 218 (1-2) ◽  
pp. 249-251 ◽  
Author(s):  
Tevfik Kalelioglu ◽  
Abdullah Genc ◽  
Nesrin Karamustafalioglu ◽  
Akif Tasdemir ◽  
Ferda Can Gungor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Status ◽  
Manic Episode ◽  
Post Treatment ◽  
Stress Index ◽  
Oxidative Stress Index ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals A novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients

2004 ◽  
Vol 82 ◽  
pp. S5
Author(s):  
T.M. Said ◽  
N. Aziz ◽  
R.K. Sharma ◽  
I. Lewis-Jones ◽  
A.J. Thomas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Infertile Male ◽  
Novel Association ◽  
Male Patients ◽  
And Oxidative Stress

scholarly journals Sex Difference in the Interrelationship Between TNF-α and Oxidative Stress Status in First-episode Drug-naïve Schizophrenia

2020 ◽  
Author(s):  
Minghuan Zhu ◽  
Zhenjing Liu ◽  
Jaelin Rippe ◽  
Mst. Sadia Sultana ◽  
Kang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sex Differences ◽  
Sex Difference ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Healthy Controls ◽  
Tnf Α ◽  
Drug Naïve ◽  
Male Patients ◽  
And Oxidative Stress

Abstract BackgroundIncreasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many aspects of schizophrenia including clinical characteristics, cytokines and OxS markers. However, to the best of our knowledge, there is no study investigating sex differences in the association between TNF-α, the OxS system, and their interaction with clinical symptoms in schizophrenia patients, especially in first-episode drug-naïve (FEDN) patients. MethodsA total of 119 FEDN schizophrenia patients and 135 healthy controls were recruited for this study. Serum TNF-α, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA) were measured. The Positive and Negative Syndrome Scale (PANSS) was applied to evaluate psychotic symptoms. Two-way ANOVA, partial correlation analysis and multivariate regression analysis were performed. ResultsA sex difference in MDA levels was demonstrated only in healthy controls (F = 7.06, p Bonferroni = 0.045) and not seen in patients. Furthermore, only male patients had higher MDA levels than male controls (F = 8.19, p Bonferroni = 0.03). Additionally, sex differences were observed in the association of TNF-α and MDA levels with psychotic symptoms (all pBonferroni<0.05). The interaction of TNF-α and MDA was only associated with general psychopathology symptom in male patients (B = -0.07, p = 0.02). ConclusionOur results demonstrate the sex difference in the relationship between TNF-α, MDA, and their interaction with psychopathological symptoms of patients with schizophrenia.

scholarly journals Sex difference in the interrelationship between TNF-α and oxidative stress status in first-episode drug-naïve schizophrenia

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Minghuan Zhu ◽  
Zhenjing Liu ◽  
Yanhong Guo ◽  
Mst. Sadia Sultana ◽  
Kang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sex Differences ◽  
Sex Difference ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Healthy Controls ◽  
Tnf Α ◽  
Drug Naïve ◽  
Male Patients ◽  
And Oxidative Stress

Abstract Background Increasing evidence indicates that dysregulated TNF-α and oxidative stress (OxS) contribute to the pathophysiology of schizophrenia. Additionally, previous evidence has demonstrated sex differences in many aspects of schizophrenia including clinical characteristics, cytokines, and OxS markers. However, to the best of our knowledge, there is no study investigating sex differences in the association between TNF-α, the OxS system, and their interaction with clinical symptoms in schizophrenia patients, especially in first-episode drug-naïve (FEDN) patients. Methods A total of 119 FEDN schizophrenia patients and 135 healthy controls were recruited for this study. Serum TNF-α, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and malondialdehyde (MDA) were measured. The Positive and Negative Syndrome Scale (PANSS) was applied to evaluate psychotic symptoms. Two-way ANOVA, partial correlation analysis, and multivariate regression analysis were performed. Results A sex difference in MDA levels was demonstrated only in healthy controls (F = 7.06, pBonferroni = 0.045) and not seen in patients. Furthermore, only male patients had higher MDA levels than male controls (F = 8.19, pBonferroni = 0.03). Additionally, sex differences were observed in the association of TNF-α and MDA levels with psychotic symptoms (all pBonferroni < 0.05). The interaction of TNF-α and MDA was only associated with general psychopathology symptom in male patients (B = − 0.07, p = 0.02). Conclusion Our results demonstrate the sex difference in the relationship between TNF-α, MDA, and their interaction with psychopathological symptoms of patients with schizophrenia.

Importance of metal ion metabolism and oxidative stress in male patients suffered with porphyria cutanea tarda

2007 ◽  
Vol 148 (23) ◽  
pp. 1095-1100 ◽  
Author(s):  
Edit Székely ◽  
Gyöngyi Tasnádi ◽  
Klára Szentmihályi ◽  
Andrea Almási ◽  
Márta Bor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Porphyria Cutanea Tarda ◽  
Male Patients ◽  
And Oxidative Stress

Az elmúlt évtizedekben egyre több betegségről derült ki, hogy patogenezisében az oxidatív stressznek és a fémionoknak fontos szerepük van. Ez a magyarázata annak, hogy az antioxidáns-kezelés jelentősége felértékelődött, és napjaink kutatásaiban is előtérbe került. Porphyria cutanea tardában (PCT) a hem bioszintézise károsodik, amely az uroporfirinogén-dekarboxiláz enzim csökkent aktivitásának következtében alakul ki. A hem-prekurzorok akkumulálódnak a vérben, a májban és a bőrben. A hem-prekurzorok és a porfirin a széklettel és a vizelettel ürülnek. Az enzimdefektus autoszomális domináns. A bőrtünetek napfény hatására felerősödnek. Ennek oka a bőrben felszaporodó uroporfirinek és a heptakarboxilporfirin fényérzékenyítő, valamint a vas lipidperoxidációt kiváltó hatása. A genetikai eredet mellett az alkoholfogyasztás, hepatotoxikus vegyületek, ösztrogén és a vírusfertőzések is hozzájárulnak a betegség kialakulásához. Az elfogadott kezelési mód az időnkénti vérlebocsátás. A májkárosodás talaján kialakuló, sporadikus porphyria cutanea tarda esetében a felhalmozódó vas felelős elsősorban az oxidatív stressz kialakulásáért. Megváltozik a betegek redox-homeostasisa és az antioxidánsszint csökken. A máj redoxstátuszának vizsgálata, valamint az antioxidáns kiegészítő kezelés hatásának követése phlebotomizált porphyria cutanea tardában szenvedő betegeknél a klinikai diagnosztika mellett biokémiai és fémanalitikai módszerekkel történhet. Vizsgálatok igazolták, hogy a phlebotomia jó kezelési módszernek bizonyult a phototoxikus bőrtünetek kezelésében, de az eljárás nem változtatta meg kedvezően a fémionok egymáshoz viszonyított arányát a betegek vérében.

Sign in / Sign up

Export Citation Format

Share Document