Brain-derived neurotrophic factor (BDNF) and oxidative stress in heroin-dependent male patients undergoing methadone maintenance treatment

2017 ◽  
Vol 249 ◽  
pp. 46-50 ◽  
Author(s):  
Meng-Chang Tsai ◽  
Tiao-Lai Huang
Keyword(s):  
Oxidative Stress ◽  
Neurotrophic Factor ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Brain Derived Neurotrophic Factor ◽  
Male Patients ◽  
And Oxidative Stress

Predicting the Outcome of Methadone Maintenance Treatment with the Negative Treatment Indicators Content Scale from the MMPI-2

2003 ◽  
Vol 93 (3_suppl) ◽  
pp. 1056-1058
Author(s):  
Robert J. Craig ◽  
Ronald E. Olson
Keyword(s):  
Treatment Outcome ◽  
Predictive Validity ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Substance Abusers ◽  
Methadone Maintenance ◽  
Content Scale ◽  
Independent Variable ◽  
Male Patients

Scores on the Negative Treatment Indicators content scale from the MMPI-2 were not significantly correlated with 5 measures of treatment outcome among 108 male patients on methadone maintenance. These results and those from other studies using this content scale as an independent variable with substance abusers suggest that the scale has yet to demonstrate consistent predictive validity with this population.

Effect of Methadone Maintenance on Expression of BDNF and CREB Genes in Brain VTA of Male Morphine Treated Rats

2021 ◽  
Vol 22 ◽  
Author(s):  
Marzieh Rezai ◽  
Mohammad Reza Hajizadeh ◽  
Mehdi Mahmoodi ◽  
Seyedeh Atekeh Torabizadeh ◽  
Mojgan Noroozi Karimabad
Keyword(s):  
Serum Level ◽  
Cyclic Amp ◽  
Neurotrophic Factor ◽  
Methadone Maintenance Treatment ◽  
Maintenance Treatment ◽  
Methadone Maintenance ◽  
Vital Role ◽  
Control Group ◽  
Element Binding Protein ◽  
Cyclic Amp Response Element

Background: Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). BDNF and CREB play a vital role in protecting and regulating the proper functioning of neurons. There has not been any study on the effect of methadone maintenance treatment and its comparison with morphine. Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Methods: I Morphine independent reduces the expression level of Brain-derived Neurotrophic Factor (BDNF) and Cyclic-AMP Response Element Binding protein (CREB). BDNF and CREB play a vital role in protecting and regulating the proper functioning of neurons. There has not been any study on the effect of methadone maintenance treatment and its comparison with morphine. Therefore, this study was conducted to examine the effect of methadone maintenance on the expression of BDNF and CREB genes in brain VTA of male morphine treated rats Results: According to the findings of this study, similar to morphine treated group, methadone maintenance in morphine treated animals led to significant reduction in the expression of BDNF and CREB genes at VTA as well as BDNF serum level compared with control group. Conclusion: It was concluded that methadone, like morphine, causes significant reduction in the expression of BDNF and CREB genes in brain VTA area of rat as well as BDNF serum level compared with control group.

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