Faculty Opinions recommendation of G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway.

2009 ◽  
Author(s):  
Kenneth Boheler ◽  
Maria Grazia Perino
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Signaling Pathway ◽  
G Protein ◽  
Embryonic Stem ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Cardiac Lineage ◽  
G Protein Coupled ◽  
Kinase Signaling Pathway

Multiple analyses of G-protein coupled receptor (GPCR) expression in the neural differentiation from embryonic stem cells

2011 ◽  
Vol 71 ◽  
pp. e126
Author(s):  
Naoko Kuzumaki ◽  
Michiko Narita ◽  
Yusuke Hamada ◽  
Atsumi Nagasawa ◽  
Yohei Okada ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
G Protein ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals G Protein Coupled Receptors in Embryonic Stem Cells: A Role for Gs-Alpha Signaling

PLoS ONE ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. e9105 ◽  
Author(s):  
Brian T. Layden ◽  
Marsha Newman ◽  
Fei Chen ◽  
Amanda Fisher ◽  
William L. Lowe
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
G Protein ◽  
Embryonic Stem ◽  
G Protein Coupled Receptors ◽  
Gs Alpha ◽  
G Protein Coupled

scholarly journals Cold-Inducible RNA-Binding Protein Bypasses Replicative Senescence in Primary Cells through Extracellular Signal-Regulated Kinase 1 and 2 Activation

2009 ◽  
Vol 29 (7) ◽  
pp. 1855-1868 ◽  
Author(s):  
Ana Artero-Castro ◽  
Francisco B. Callejas ◽  
Josep Castellvi ◽  
Hiroshi Kondoh ◽  
Amancio Carnero ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Rna Binding ◽  
Replicative Senescence ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Embryonic Stem ◽  
Primary Cells ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal

ABSTRACT Embryonic stem cells are immortalized cells whose proliferation rate is comparable to that of carcinogenic cells. To study the expression of embryonic stem cell genes in primary cells, genetic screening was performed by infecting mouse embryonic fibroblasts (MEFs) with a cDNA library from embryonic stem cells. Cold-inducible RNA-binding protein (CIRP) was identified due to its ability to bypass replicative senescence in primary cells. CIRP enhanced extracellular signal-regulated kinase 1 and 2 (ERK1/2) phosphorylation, and treatment with an MEK inhibitor decreased the proliferation caused by CIRP. In contrast to CIRP upregulation, CIRP downregulation decreased cell proliferation and resulted in inhibition of phosphorylated ERK1/2 inhibition. This is the first evidence that ERK1/2 activation, through the same mechanism as that described for a Val12 mutant K-ras to induce premature senescence, is able to bypass senescence in the absence of p16INK4a, p21WAF1, and p19ARF upregulation. Moreover, these results show that CIRP functions by stimulating general protein synthesis with the involvement of the S6 and 4E-BP1 proteins. The overall effect is an increase in kinase activity of the cyclin D1-CDK4 complex, which is in accordance with the proliferative capacity of CIRP MEFs. Interestingly, CIRP mRNA and protein were upregulated in a subgroup of cancer patients, a finding that may be of relevance for cancer research.

Role of G-protein coupled receptors in the neural differentiation from embryonic stem cells

2010 ◽  
Vol 68 ◽  
pp. e134
Author(s):  
Naoko Kuzumaki ◽  
Atsuo Suzuki ◽  
Michiko Narita ◽  
Satoshi Imai ◽  
Yohei Okada ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
G Protein ◽  
Neural Differentiation ◽  
Embryonic Stem ◽  
G Protein Coupled Receptors ◽  
G Protein Coupled

Sphingosine 1-Phosphate Regulation of Extracellular Signal-Regulated Kinase-1/2 in Embryonic Stem Cells

2009 ◽  
Vol 18 (9) ◽  
pp. 1319-1330 ◽  
Author(s):  
Alayna Rodgers ◽  
David Mormeneo ◽  
Jaclyn S. Long ◽  
Antonio Delgado ◽  
Nigel J. Pyne ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Extracellular Signal Regulated Kinase ◽  
Phosphate Regulation ◽  
Extracellular Signal ◽  
Sphingosine 1 Phosphate
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