Faculty Opinions recommendation of Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation.

2009 ◽  
Author(s):  
Ralf Paus ◽  
Katja Meyer ◽  
Jennifer Elisabeth Klöpper
Keyword(s):  
Mast Cell ◽  
Inflammatory Diseases ◽  
Cell Expression

Increased mast cell expression of PAR-2 in skin inflammatory diseases and release of IL-8 upon PAR-2 activation

2010 ◽  
Vol 19 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Ricardo Filipe da Silva Carvalho ◽  
Gunnar Nilsson ◽  
Ilkka Tapani Harvima
Keyword(s):  
Mast Cell ◽  
Inflammatory Diseases ◽  
Cell Expression

scholarly journals The transcriptional program, functional heterogeneity, and clinical targeting of mast cells

2017 ◽  
Vol 214 (9) ◽  
pp. 2491-2506 ◽  
Author(s):  
Gökhan Cildir ◽  
Harshita Pant ◽  
Angel F. Lopez ◽  
Vinay Tergaonkar
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Immunoglobulin E ◽  
Inflammatory Diseases ◽  
Small Population ◽  
Transcriptional Program ◽  
Cell Functions ◽  
New Concepts ◽  
Health And Disease ◽  
Ige Mediated

Mast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen–immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.

Mast cell expression in oral lichen planus: A systematic review

2019 ◽  
Vol 10 (4) ◽  
Author(s):  
Jayanth Kumar Vadivel ◽  
Meera Govindarajan ◽  
Elangovan Somasundaram ◽  
Arvind Muthukrishnan
Keyword(s):  
Systematic Review ◽  
Mast Cell ◽  
Lichen Planus ◽  
Oral Lichen Planus ◽  
Cell Expression ◽  
Oral Lichen

scholarly journals The regulatory B cell–mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity

2019 ◽  
Vol 5 (7) ◽  
pp. eaav8152 ◽  
Author(s):  
Hyuk Soon Kim ◽  
Min Bum Lee ◽  
Dajeong Lee ◽  
Keun Young Min ◽  
Jimo Koo ◽  
...  
Keyword(s):  
Mast Cell ◽  
Inflammatory Diseases ◽  
Interleukin 10 ◽  
Lymphoid Cells ◽  
Peripheral Tolerance ◽  
Contact Hypersensitivity ◽  
Lymphoid Tissues ◽  
Dependent Manner ◽  
Peripheral Tissues ◽  
Regulatory B Cell

The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)–producing regulatory B (IL-10+ Breg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10+ Breg cells are generated and maintained is still very limited. Here, we found that IL-10+ Breg cells suppress the activation of IL-13–producing type 2 innate lymphoid cells (IL-13+ ILC2s) in an IL-10–dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10+ Breg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10+ Breg cells, and IL-13+ ILC2s in CHS.

Aqueous Extract of Mosla chinensis Inhibits Mast Cell-Mediated Allergic Inflammation

2012 ◽  
Vol 40 (06) ◽  
pp. 1257-1270 ◽  
Author(s):  
Hui-Hun Kim ◽  
Jin-Su Yoo ◽  
Tae-Yong Shin ◽  
Sang-Hyun Kim
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Histamine Release ◽  
Aqueous Extract ◽  
Proinflammatory Cytokines ◽  
Immunoglobulin E ◽  
Inflammatory Diseases ◽  
Allergic Inflammation ◽  
Inhibitory Effect ◽  
Ige Mediated

Allergic inflammatory diseases such as food allergy, asthma, sinusitis, and atopic dermatitis are increasing worldwide. In this study, we investigated the effects of aqueous extract of Mosla chinensis Max. (AMC) on mast cell-mediated allergic inflammation and studied the possible mechanism of this action. AMC inhibited compound 48/80-induced systemic and immunoglobulin E (IgE)-mediated local anaphylaxis. AMC reduced intracellular calcium levels and downstream histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. In addition, AMC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-8 in human mast cells. The inhibitory effect of AMC on cytokine expression was nuclear factor (NF)-κB dependent. Our results indicate that AMC inhibits mast cell-mediated allergic inflammatory reaction by suppressing histamine release and expression of proinflammatory cytokines and the involvement of calcium and NF-κB in these effects. AMC might be a possible therapeutic candidate for allergic inflammatory disorders.

scholarly journals Infiltration of Mast Cells in Scalp Biopsies of Patients with Alopecia Areata or Androgenic Alopecia Versus Healthy Individuals: A Case-Control Study

2020 ◽  
Vol 9 ◽  
pp. 1962
Author(s):  
Soheila Nasiri ◽  
Alireza Salehi ◽  
Azadeh Rakhshan
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Alopecia Areata ◽  
Inflammatory Diseases ◽  
Androgenic Alopecia ◽  
Cell Counts ◽  
Healthy Control ◽  
Over 40 Years ◽  
Control Study

Background: Alopecia areata (AA) and androgenic alopecia (AGA) are the most common types of alopecias. Recently, the role of mast cells in inflammatory diseases has become the focus of many studies. However, few studies have been conducted on their role in AA and AGA. Therefore, our study aimed to quantitatively evaluate the presence of mast cells in the AA and AGA specimens.Materials and Methods: Three groups of AA, AGA, and healthy control were studied (each group with 20 subjects). Patients were randomly selected from those referred to the dermatology clinics of Shahid Beheshti University. Specimens were obtained from the scalp, and perifollicular and perivascular areas were investigated. Results: Significantly higher perifollicular and perivascular mast cell counts were seen in both AGA and AA groups compared to healthy control (P<0.001 for both). Moreover, AA patients had more frequent perivascular mast cells than the AGA group (P=0.042). Among patients aged <40 years, perifollicular and perivascular mast cell counts were not significantly different among the three groups; however, subjects over 40 years of age in both groups had significantly more perifollicular and perivascular mast cells than healthy participants. There was a significant positive correlation between disease severity and mast cell counts in both perifollicular and perivascular areas in AA patients (P=0.001 for both). Conclusion: There was a significantly increased infiltration of mast cells in AA and AGA patients, and this increase was age and severity dependent. Moreover, the increase in mast cell proliferation is more dominant in AA patients. [GMJ.2020;9:e1962]

scholarly journals Mast cell expression of IL-33, ST2 and TSLPR in the skin of atopic dermatitis post-allergen exposure

2019 ◽  
Vol 143 (2) ◽  
pp. AB65
Author(s):  
Lucie White ◽  
Xuanzhi Yin ◽  
Emma Price ◽  
Sai Sakktee Krisna ◽  
Hermenio Lima ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cell ◽  
Allergen Exposure ◽  
Cell Expression

scholarly journals P-Selectin Expression in Canine Cutaneous Inflammatory Diseases and Mast Cell Tumors

1998 ◽  
Vol 35 (2) ◽  
pp. 85-93 ◽  
Author(s):  
S. Chénier ◽  
M. Doré
Keyword(s):  
Mast Cell ◽  
Blood Vessels ◽  
Adhesion Molecules ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Inflammatory Skin Diseases ◽  
Mast Cell Tumors ◽  
Initial Adhesion ◽  
Selectin Family ◽  
Local Recruitment

P-selectin, a member of the selectin family of adhesion molecules, mediates the initial adhesion of leukocytes to the blood vessel wall during their emigration from the circulation. Adhesion molecules play an important role in the pathogenesis of several diseases, including various skin conditions. The objectives of the present study were to characterize the expression of vascular P-selectin in the skin of dogs suffering from inflammatory diseases or from common cutaneous neoplasms, and to determine if a correlation exists between P-selectin expression and inflammatory cell infiltration in these conditions. Immunohistochemistry was performed on formalin-fixed canine skin using a specific anti-canine P-selectin monoclonal antibody (MD3). Results showed that P-selectin was minimally expressed in normal canine skin. However, the number of P-selectin-expressing blood vessels was significantly increased ( P < 0.05) in cases of allergic dermatitis, autoimmune dermatitis, pyogranulomatous dermatitis, dermatophytosis, and panniculitis. Highest P-selectin expression (percentage of MD3-positive vessels and intensity of the reaction) was observed in cases of autoimmune and pyogranulomatous dermatitis (55.3 ± 7.4 and 44.0 ± 9.9% P-selectin-positive vessels, respectively). In all conditions studied, a positive correlation existed between the number of P-selectin-positive blood vessels and the number of infiltrating leukocytes ( r = 0.556, P < 0.01). A significant number of blood vessels in mast cell tumors also expressed P-selectin, whereas no staining was observed in any of the histiocytomas examined. These results reveal that P-selectin expression is increased in different types of canine inflammatory skin diseases and suggest that P-selectin could participate in the local recruitment of leukocytes in canine cutaneous diseases.

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