Faculty Opinions recommendation of Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA-CLEC16A-SOCS1 gene complex.

2011 ◽  
Author(s):  
Koen Vandenbroeck
Keyword(s):  
Multiple Sclerosis ◽  
Gene Complex ◽  
Multiple Sclerosis Susceptibility

scholarly journals Interrogating the complex role of chromosome 16p13.13 in multiple sclerosis susceptibility: independent genetic signals in the CIITA–CLEC16A–SOCS1 gene complex

2011 ◽  
Vol 20 (17) ◽  
pp. 3517-3524 ◽  
Author(s):  
Rebecca L. Zuvich ◽  
William S. Bush ◽  
Jacob L. McCauley ◽  
Ashley H. Beecham ◽  
Philip L. De Jager ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Complex ◽  
Multiple Sclerosis Susceptibility

The interleukin-1 gene family in multiple sclerosis susceptibility and disease course

2003 ◽  
Vol 9 (6) ◽  
pp. 535-539 ◽  
Author(s):  
Tineke Hooper-van Veen ◽  
Hans M Schrijver ◽  
Antoon Zwiers ◽  
J Bart A Crusius ◽  
Dirk L Knol ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gene Polymorphisms ◽  
Interleukin 1 ◽  
Progression Rate ◽  
Disease Course ◽  
Resonance Imaging ◽  
Multiple Sclerosis Susceptibility ◽  
Specific Allele ◽  
Magnetic Resonance Imaging Mri

Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our patient population (492 MS patients and 228 controls). In the present study, we investigated the role of the IL- 1A - 889, IL-1B - 511, IL-1B+3953 and IL-1RN VNTR gene polymorphisms in MS. In addition, we performed preliminary analyses on longitudinal magnetic resonance imaging (MRI) data. We found no associations between the polymorphisms and susceptibility to MS or clinical features. In addition, we observed no significant effect of the polymorphisms on brain or lesion volumes, Based on our data and those from the literature, one can conclude that there is currently no evidence to support a role for the IL-1 genes in MS.

The role of MEFV gene mutations in Multiple Sclerosis susceptibility

2010 ◽  
Vol 298 (1-2) ◽  
pp. 163
Author(s):  
Hamid Zahednasab ◽  
Mohammad Saadatnia ◽  
M. Reza Jabalameli ◽  
Seyed Amir Bahreini
Keyword(s):  
Multiple Sclerosis ◽  
Mefv Gene ◽  
Gene Mutations ◽  
Multiple Sclerosis Susceptibility

Lack of evidence for a role of the myelin basic protein gene in multiple sclerosis susceptibility in Sardinian patients

2002 ◽  
Vol 249 (11) ◽  
pp. 1552-1555 ◽  
Author(s):  
Eleonora Cocco ◽  
Cristina Mancosu ◽  
Elisabetta Fadda ◽  
Maria Rita Murru ◽  
Gianna Costa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Protein Gene ◽  
Multiple Sclerosis Susceptibility ◽  
Myelin Basic Protein Gene

Role of immune gene variants in multiple sclerosis susceptibility and severity: Genetic burden consequences on immune cell functionality

2014 ◽  
Vol 275 (1-2) ◽  
pp. 50
Author(s):  
Mohamed El Behi ◽  
Vincent Damotte ◽  
Lena Guillot-nöel ◽  
Violetta Zujovic ◽  
Isabelle Rebeix ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Immune Cell ◽  
Immune Gene ◽  
Gene Variants ◽  
Multiple Sclerosis Susceptibility ◽  
Genetic Burden ◽  
Cell Functionality

scholarly journals Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells

2021 ◽  
Author(s):  
Anna M. Eriksson ◽  
Ingvild Sørum Leikfoss ◽  
Greger Abrahamsen ◽  
Vibeke Sundvold Gjerstad ◽  
Martine Mesel Isom ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cells ◽  
Susceptibility Gene ◽  
Multiple Sclerosis Susceptibility

scholarly journals Investigation of the Role of Mitochondrial DNA in Multiple Sclerosis Susceptibility

PLoS ONE ◽  
2008 ◽  
Vol 3 (8) ◽  
pp. e2891 ◽  
Author(s):  
Maria Ban ◽  
Joanna Elson ◽  
Amie Walton ◽  
Douglas Turnbull ◽  
Alastair Compston ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Mitochondrial Dna ◽  
Multiple Sclerosis Susceptibility

The role of non-HLA single nucleotide polymorphisms in multiple sclerosis susceptibility

2010 ◽  
Vol 229 (1-2) ◽  
pp. 5-15 ◽  
Author(s):  
Seyed Amir Bahreini ◽  
M. Reza Jabalameli ◽  
Mohammad Saadatnia ◽  
Hamid Zahednasab
Keyword(s):  
Multiple Sclerosis ◽  
Single Nucleotide Polymorphisms ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Multiple Sclerosis Susceptibility
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