Faculty Opinions recommendation of The role of the TRP channel NompC in Drosophila larval and adult locomotion.

The epithelial Ca2+ channels TRPV5 and TRPV6 are the most Ca2+-selective members of the TRP channel superfamily. These channels are the prime target for hormonal control of the active Ca2+ flux from the urine space or intestinal lumen to the blood compartment. Insight into their regulation is, therefore, pivotal in our understanding of the (patho)physiology of Ca2+ homeostasis. The recent elucidation of TRPV5/6-associated proteins has provided new insight into the molecular mechanisms underlying the regulation of these channels. In this review, we describe the various means of TRPV5/6 regulation, the role of channel-associated proteins herein, and the relationship between both processes.

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Role of N-Terminus in the Function of the Yvc1p Saccharomyces Cerevisiae TRP Channel

Biophysical Journal ◽

10.1016/j.bpj.2011.11.1891 ◽

2012 ◽

Vol 102 (3) ◽

pp. 345a

Author(s):

Samantha Ho ◽

Lise Thomas

Keyword(s):

Saccharomyces Cerevisiae ◽

Trp Channel ◽

N Terminus

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276 Does TRP channel play a role of extracellular calcium sensing in urethral smooth muscle?

European Urology Supplements ◽

10.1016/s1569-9056(16)60278-6 ◽

2016 ◽

Vol 15 (3) ◽

pp. e276

Author(s):

S. Kajioka ◽

M. Hayashi ◽

T. Maki ◽

R. Takahashi ◽

M. Etoh

Keyword(s):

Smooth Muscle ◽

Extracellular Calcium ◽

Trp Channel ◽

Calcium Sensing ◽

Urethral Smooth Muscle

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The role of π-helices in TRP channel gating

Current Opinion in Structural Biology ◽

10.1016/j.sbi.2019.06.011 ◽

2019 ◽

Vol 58 ◽

pp. 314-323 ◽

Cited By ~ 14

Author(s):

Lejla Zubcevic ◽

Seok-Yong Lee

Keyword(s):

Channel Gating ◽

Trp Channel

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Role of TRP Channels in the Regulation of the Endosomal Pathway

Physiology ◽

10.1152/physiol.00048.2010 ◽

2011 ◽

Vol 26 (1) ◽

pp. 14-22 ◽

Cited By ~ 43

Author(s):

Ken Abe ◽

Rosa Puertollano

Keyword(s):

Membrane Trafficking ◽

Transient Receptor Potential ◽

Trp Channels ◽

Ion Homeostasis ◽

Receptor Potential ◽

Trp Channel ◽

Endosomal Pathway ◽

Transient Receptor

Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca2+ from endosomes and lysosomes.

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Changes in TRP Channels Expression in Painful Conditions

The Open Pain Journal ◽

10.2174/1876386301306010010 ◽

2013 ◽

Vol 6 (1) ◽

pp. 10-22 ◽

Cited By ~ 8

Author(s):

Mahendra Bishnoi ◽

Louis S. Premkumar

Keyword(s):

Transient Receptor Potential ◽

Trp Channels ◽

Receptor Potential ◽

Trp Channel ◽

Current Status ◽

Behavioral Models ◽

Tremendous Progress ◽

Analgesic Agents ◽

Transient Receptor

Over the last fifteen years after the successful cloning of the first nociceptive Transient Receptor Potential (TRP) channel, TRP Vanilloid 1, other members of the TRP channel family have been cloned, characterized and implicated in different modalities of pain. Tremendous progress has been made with regard to the specific role of these TRP channels in nociception using electrophysiological and molecular methods, along with behavioral models combined with gene disruption techniques. This review summarizes the evidence supporting the role of TRP channels (TRP Vanilloid 1, TRP Vanilloid 2, TRP Vanilloid 3, TRP Vanilloid 4, TRP Ankyrin 1, TRP Melastatin 2, TRP Melastatin 3, TRP Melastatin 8, TRP Mucolipin 3 and TRP Canonical 1, 6) involved in nociception. The review also highlights the current status and future avenues for developing TRP channel modulators as analgesic agents.

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Phosphatidylinositol 3,5-Bisphosphate regulates Ca2+ Transport During Yeast Vacuolar Fusion through Activation of the Ca2+ ATPase Pmc1

10.1101/533067 ◽

2019 ◽

Author(s):

Gregory E. Miner ◽

Katherine D. Sullivan ◽

Annie Guo ◽

Matthew L. Starr ◽

EZ C. Ellis ◽

...

Keyword(s):

Osmotic Stress ◽

Lipid Bilayers ◽

Dual Role ◽

Snare Complex ◽

Trp Channel ◽

Complex Assembly ◽

Hyperosmotic Shock ◽

Vacuole Fusion ◽

Opposing Effects

ABSTRACTThe transport of Ca2+ across membranes precedes the fusion and fission of various lipid bilayers. Yeast vacuoles during hyperosmotic shock become fragmented through fission events that require Ca2+ efflux of their luminal stores through the TRP channel Yvc1. This requires the production of the lipid PI(3,5)P2 by Fab1. Ca2+ is also released during vacuole fusion upon trans-SNARE complex assembly, however, the role of PI(3,5)P2 remains unclear. Here we demonstrate that elevated PI(3,5)P2 levels abolish Ca2+ efflux during fusion, indicating that PI(3,5)P2 has opposing effects on Ca2+ transport in fission versus fusion. Notably, Ca2+ efflux was enhanced when PI(3,5)P2 levels were reduced. Importantly, the effect of PI(3,5)P2 on Ca2+ flux was independent of Yvc1. Rather, the effect was dependent on the Ca2+ pump Pmc1. Vacuoles lacking Pmc1 were resistant to the effects of PI(3,5)P2, while those lacking Yvc1 remained sensitive. Furthermore altering PI(3,5)P2 levels affects the interactions of Pmc1 with the Vo component Vph1 and the R-SNARE Nyv1. We now propose a model in which elevated PI(3,5)P2 activates continued Pmc1 function to prevent the accumulation of released extraluminal Ca2+.SummaryDuring osmotic stress PI(3,5)P2 triggers Ca2+ release from vacuoles. Here we show PI(3,5)P2 stimulates Ca2+ uptake by vacuoles during fusion, illustrating that it has a dual role in Ca2+ transport.

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